H2N2V1, Ncbi, Checkpoint, bibRecord, 001126

Antigenic memory to influenza A viruses in man determined by monovalent vaccines.

Identifieur interne : 001126 ( Ncbi/Checkpoint ); précédent : 001125; suivant : 001127

Antigenic memory to influenza A viruses in man determined by monovalent vaccines.

Auteurs : W. M. Marine ; J. E. Thomas

Source :

Postgraduate Medical Journal [ 0032-5473 ] ; 1979.

RBID : PMC:2425381

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Anticorps antiviraux (biosynthèse), Antigènes viraux (immunologie), Enfant, Facteurs de l'âge, Grippe humaine (immunologie), Humains, Hémagglutinines virales (immunologie), Mémoire immunologique, Sujet âgé, Vaccins antigrippaux (immunologie), Virus de la grippe A (immunologie).
MESH :
- biosynthèse : Anticorps antiviraux.
- immunologie : Antigènes viraux, Grippe humaine, Hémagglutinines virales, Vaccins antigrippaux, Virus de la grippe A.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Facteurs de l'âge, Humains, Mémoire immunologique, Sujet âgé.

English descriptors

KwdEn :
- Adolescent, Adult, Age Factors, Aged, Antibodies, Viral (biosynthesis), Antigens, Viral (immunology), Child, Hemagglutinins, Viral (immunology), Humans, Immunologic Memory, Influenza A virus (immunology), Influenza Vaccines (immunology), Influenza, Human (immunology), Middle Aged.
MESH :
- chemical , biosynthesis : Antibodies, Viral.
- chemical , immunology : Antigens, Viral, Hemagglutinins, Viral, Influenza Vaccines.
- immunology : Influenza A virus, Influenza, Human.
- Adolescent, Adult, Age Factors, Aged, Child, Humans, Immunologic Memory, Middle Aged.

Abstract

This study was conducted to test the limits of the doctrine of 'original antigenic sin' in influenza A. The design included use of zonal purified 1000 CCA (chick cell agglutinating) units monovalent vaccines consisting of H0N1, H1N1, H2N2 and H3N2. Age cohorts with different primary influenza A infections were established for the 687 volunteers. The vaccines administered to each age cohort were selected to test the responsiveness of original antigenic sin antibody to homologous and heterologous challenge. Anamnestic responses were demonstrated with Hsw1n1,H0N1, and H1N1 and with H2N2 and H3N2 but not between the groups. The synthesis of these findings is that there are 2 original antigenic sins - 2 families of influenza A viruses.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2425381

PubMed: 461278
PubMed Central: 2425381

Affiliations:

Links to Exploration step

PMC:2425381

Le document en format XML

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<term>Antigens, Viral (immunology)</term>
<term>Child</term>
<term>Hemagglutinins, Viral (immunology)</term>
<term>Humans</term>
<term>Immunologic Memory</term>
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<term>Influenza Vaccines (immunology)</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Anticorps antiviraux (biosynthèse)</term>
<term>Antigènes viraux (immunologie)</term>
<term>Enfant</term>
<term>Facteurs de l'âge</term>
<term>Grippe humaine (immunologie)</term>
<term>Humains</term>
<term>Hémagglutinines virales (immunologie)</term>
<term>Mémoire immunologique</term>
<term>Sujet âgé</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Virus de la grippe A (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term>
<term>Hemagglutinins, Viral</term>
<term>Influenza Vaccines</term>
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<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes viraux</term>
<term>Grippe humaine</term>
<term>Hémagglutinines virales</term>
<term>Vaccins antigrippaux</term>
<term>Virus de la grippe A</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term>
<term>Influenza, Human</term>
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<term>Adult</term>
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<term>Aged</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Enfant</term>
<term>Facteurs de l'âge</term>
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<term>Sujet âgé</term>
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<front><div type="abstract" xml:lang="en"><p>This study was conducted to test the limits of the doctrine of 'original antigenic sin' in influenza A. The design included use of zonal purified 1000 CCA (chick cell agglutinating) units monovalent vaccines consisting of H0N1, H1N1, H2N2 and H3N2. Age cohorts with different primary influenza A infections were established for the 687 volunteers. The vaccines administered to each age cohort were selected to test the responsiveness of original antigenic sin antibody to homologous and heterologous challenge. Anamnestic responses were demonstrated with Hsw1n1,H0N1, and H1N1 and with H2N2 and H3N2 but not between the groups. The synthesis of these findings is that there are 2 original antigenic sins - 2 families of influenza A viruses.</p>
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Antigenic memory to influenza A viruses in man determined by monovalent vaccines.

Antigenic memory to influenza A viruses in man determined by monovalent vaccines.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
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