Oseltamivir Prophylaxis Reduces Inflammation and Facilitates Establishment of Cross-Strain Protective T Cell Memory to Influenza Viruses
Identifieur interne : 000B85 ( Ncbi/Checkpoint ); précédent : 000B84; suivant : 000B86Oseltamivir Prophylaxis Reduces Inflammation and Facilitates Establishment of Cross-Strain Protective T Cell Memory to Influenza Viruses
Auteurs : Nicola L. Bird [Australie] ; Matthew R. Olson [Australie] ; Aeron C. Hurt [Australie] ; Christine M. Oshansky [États-Unis] ; Ding Yuan Oh [Australie] ; Patrick C. Reading [Australie] ; Brendon Y. Chua [Australie] ; Yilun Sun [États-Unis] ; Li Tang [États-Unis] ; Andreas Handel [États-Unis] ; David C. Jackson [Australie] ; Stephen J. Turner [Australie] ; Paul G. Thomas [États-Unis] ; Katherine Kedzierska [Australie]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
CD8+ T cells directed against conserved viral regions elicit broad immunity against distinct influenza viruses, promote rapid virus elimination and enhanced host recovery. The influenza neuraminidase inhibitor, oseltamivir, is prescribed for therapy and prophylaxis, although it remains unclear how the drug impacts disease severity and establishment of effector and memory CD8+ T cell immunity. We dissected the effects of oseltamivir on viral replication, inflammation, acute CD8+ T cell responses and the establishment of immunological CD8+ T cell memory. In mice, ferrets and humans, the effect of osteltamivir on viral titre was relatively modest. However, prophylactic oseltamivir treatment in mice markedly reduced morbidity, innate responses, inflammation and, ultimately, the magnitude of effector CD8+ T cell responses. Importantly, functional memory CD8+ T cells established during the drug-reduced effector phase were capable of mounting robust recall responses. Moreover, influenza-specific memory CD4+ T cells could be also recalled after the secondary challenge, while the antibody levels were unaffected. This provides evidence that long-term memory T cells can be generated during an oseltamivir-interrupted infection. The anti-inflammatory effect of oseltamivir was verified in H1N1-infected patients. Thus, in the case of an unpredicted influenza pandemic, while prophylactic oseltamivir treatment can reduce disease severity, the capacity to generate memory CD8+ T cells specific for the newly emerged virus is uncompromised. This could prove especially important for any new influenza pandemic which often occurs in separate waves.
Url:
DOI: 10.1371/journal.pone.0129768
PubMed: 26086392
PubMed Central: 4473273
Affiliations:
- Australie, États-Unis
- Géorgie (États-Unis), Tennessee, Victoria (État)
- Melbourne
- Université de Melbourne
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000A60
- to stream Pmc, to step Curation: 000A60
- to stream Pmc, to step Checkpoint: 000377
- to stream Ncbi, to step Merge: 000B85
- to stream Ncbi, to step Curation: 000B85
Links to Exploration step
PMC:4473273Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Oseltamivir Prophylaxis Reduces Inflammation and Facilitates Establishment of Cross-Strain Protective T Cell Memory to Influenza Viruses</title>
<author><name sortKey="Bird, Nicola L" sort="Bird, Nicola L" uniqKey="Bird N" first="Nicola L." last="Bird">Nicola L. Bird</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Olson, Matthew R" sort="Olson, Matthew R" uniqKey="Olson M" first="Matthew R." last="Olson">Matthew R. Olson</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hurt, Aeron C" sort="Hurt, Aeron C" uniqKey="Hurt A" first="Aeron C." last="Hurt">Aeron C. Hurt</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory (VIDRL), at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory (VIDRL), at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<wicri:noRegion>Parkville VIC 3010</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff003"><addr-line>Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oshansky, Christine M" sort="Oshansky, Christine M" uniqKey="Oshansky C" first="Christine M." last="Oshansky">Christine M. Oshansky</name>
<affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>Department of Immunology, St Jude Children’s Research Hospital, Memphis, TN 38105, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Immunology, St Jude Children’s Research Hospital, Memphis, TN 38105</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oh, Ding Yuan" sort="Oh, Ding Yuan" uniqKey="Oh D" first="Ding Yuan" last="Oh">Ding Yuan Oh</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory (VIDRL), at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory (VIDRL), at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<wicri:noRegion>Parkville VIC 3010</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Federation University, School of Applied Sciences and Biomedical Sciences, Gippsland Victoria 3842, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Federation University, School of Applied Sciences and Biomedical Sciences, Gippsland Victoria 3842</wicri:regionArea>
<wicri:noRegion>Gippsland Victoria 3842</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reading, Patrick C" sort="Reading, Patrick C" uniqKey="Reading P" first="Patrick C." last="Reading">Patrick C. Reading</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory (VIDRL), at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory (VIDRL), at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<wicri:noRegion>Parkville VIC 3010</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chua, Brendon Y" sort="Chua, Brendon Y" uniqKey="Chua B" first="Brendon Y." last="Chua">Brendon Y. Chua</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sun, Yilun" sort="Sun, Yilun" uniqKey="Sun Y" first="Yilun" last="Sun">Yilun Sun</name>
<affiliation wicri:level="2"><nlm:aff id="aff005"><addr-line>Department of Biostatistics, St Jude Children’s Research Hospital, Memphis, TN 38105, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, St Jude Children’s Research Hospital, Memphis, TN 38105</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tang, Li" sort="Tang, Li" uniqKey="Tang L" first="Li" last="Tang">Li Tang</name>
<affiliation wicri:level="2"><nlm:aff id="aff005"><addr-line>Department of Biostatistics, St Jude Children’s Research Hospital, Memphis, TN 38105, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, St Jude Children’s Research Hospital, Memphis, TN 38105</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Handel, Andreas" sort="Handel, Andreas" uniqKey="Handel A" first="Andreas" last="Handel">Andreas Handel</name>
<affiliation wicri:level="2"><nlm:aff id="aff006"><addr-line>Department of Epidemiology and Biostatistics, University of Georgia, Athens, GA 30602, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, University of Georgia, Athens, GA 30602</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jackson, David C" sort="Jackson, David C" uniqKey="Jackson D" first="David C." last="Jackson">David C. Jackson</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Turner, Stephen J" sort="Turner, Stephen J" uniqKey="Turner S" first="Stephen J." last="Turner">Stephen J. Turner</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thomas, Paul G" sort="Thomas, Paul G" uniqKey="Thomas P" first="Paul G." last="Thomas">Paul G. Thomas</name>
<affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>Department of Immunology, St Jude Children’s Research Hospital, Memphis, TN 38105, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Immunology, St Jude Children’s Research Hospital, Memphis, TN 38105</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kedzierska, Katherine" sort="Kedzierska, Katherine" uniqKey="Kedzierska K" first="Katherine" last="Kedzierska">Katherine Kedzierska</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26086392</idno>
<idno type="pmc">4473273</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473273</idno>
<idno type="RBID">PMC:4473273</idno>
<idno type="doi">10.1371/journal.pone.0129768</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000A60</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A60</idno>
<idno type="wicri:Area/Pmc/Curation">000A60</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A60</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000377</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000377</idno>
<idno type="wicri:Area/Ncbi/Merge">000B85</idno>
<idno type="wicri:Area/Ncbi/Curation">000B85</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000B85</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Oseltamivir Prophylaxis Reduces Inflammation and Facilitates Establishment of Cross-Strain Protective T Cell Memory to Influenza Viruses</title>
<author><name sortKey="Bird, Nicola L" sort="Bird, Nicola L" uniqKey="Bird N" first="Nicola L." last="Bird">Nicola L. Bird</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Olson, Matthew R" sort="Olson, Matthew R" uniqKey="Olson M" first="Matthew R." last="Olson">Matthew R. Olson</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hurt, Aeron C" sort="Hurt, Aeron C" uniqKey="Hurt A" first="Aeron C." last="Hurt">Aeron C. Hurt</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory (VIDRL), at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory (VIDRL), at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<wicri:noRegion>Parkville VIC 3010</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff003"><addr-line>Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oshansky, Christine M" sort="Oshansky, Christine M" uniqKey="Oshansky C" first="Christine M." last="Oshansky">Christine M. Oshansky</name>
<affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>Department of Immunology, St Jude Children’s Research Hospital, Memphis, TN 38105, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Immunology, St Jude Children’s Research Hospital, Memphis, TN 38105</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oh, Ding Yuan" sort="Oh, Ding Yuan" uniqKey="Oh D" first="Ding Yuan" last="Oh">Ding Yuan Oh</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory (VIDRL), at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory (VIDRL), at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<wicri:noRegion>Parkville VIC 3010</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Federation University, School of Applied Sciences and Biomedical Sciences, Gippsland Victoria 3842, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Federation University, School of Applied Sciences and Biomedical Sciences, Gippsland Victoria 3842</wicri:regionArea>
<wicri:noRegion>Gippsland Victoria 3842</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reading, Patrick C" sort="Reading, Patrick C" uniqKey="Reading P" first="Patrick C." last="Reading">Patrick C. Reading</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory (VIDRL), at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory (VIDRL), at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<wicri:noRegion>Parkville VIC 3010</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chua, Brendon Y" sort="Chua, Brendon Y" uniqKey="Chua B" first="Brendon Y." last="Chua">Brendon Y. Chua</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sun, Yilun" sort="Sun, Yilun" uniqKey="Sun Y" first="Yilun" last="Sun">Yilun Sun</name>
<affiliation wicri:level="2"><nlm:aff id="aff005"><addr-line>Department of Biostatistics, St Jude Children’s Research Hospital, Memphis, TN 38105, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, St Jude Children’s Research Hospital, Memphis, TN 38105</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tang, Li" sort="Tang, Li" uniqKey="Tang L" first="Li" last="Tang">Li Tang</name>
<affiliation wicri:level="2"><nlm:aff id="aff005"><addr-line>Department of Biostatistics, St Jude Children’s Research Hospital, Memphis, TN 38105, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, St Jude Children’s Research Hospital, Memphis, TN 38105</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Handel, Andreas" sort="Handel, Andreas" uniqKey="Handel A" first="Andreas" last="Handel">Andreas Handel</name>
<affiliation wicri:level="2"><nlm:aff id="aff006"><addr-line>Department of Epidemiology and Biostatistics, University of Georgia, Athens, GA 30602, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, University of Georgia, Athens, GA 30602</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jackson, David C" sort="Jackson, David C" uniqKey="Jackson D" first="David C." last="Jackson">David C. Jackson</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Turner, Stephen J" sort="Turner, Stephen J" uniqKey="Turner S" first="Stephen J." last="Turner">Stephen J. Turner</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thomas, Paul G" sort="Thomas, Paul G" uniqKey="Thomas P" first="Paul G." last="Thomas">Paul G. Thomas</name>
<affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>Department of Immunology, St Jude Children’s Research Hospital, Memphis, TN 38105, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Immunology, St Jude Children’s Research Hospital, Memphis, TN 38105</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kedzierska, Katherine" sort="Kedzierska, Katherine" uniqKey="Kedzierska K" first="Katherine" last="Kedzierska">Katherine Kedzierska</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>CD8<sup>+</sup>
T cells directed against conserved viral regions elicit broad immunity against distinct influenza viruses, promote rapid virus elimination and enhanced host recovery. The influenza neuraminidase inhibitor, oseltamivir, is prescribed for therapy and prophylaxis, although it remains unclear how the drug impacts disease severity and establishment of effector and memory CD8<sup>+</sup>
T cell immunity. We dissected the effects of oseltamivir on viral replication, inflammation, acute CD8<sup>+</sup>
T cell responses and the establishment of immunological CD8<sup>+</sup>
T cell memory. In mice, ferrets and humans, the effect of osteltamivir on viral titre was relatively modest. However, prophylactic oseltamivir treatment in mice markedly reduced morbidity, innate responses, inflammation and, ultimately, the magnitude of effector CD8<sup>+</sup>
T cell responses. Importantly, functional memory CD8<sup>+</sup>
T cells established during the drug-reduced effector phase were capable of mounting robust recall responses. Moreover, influenza-specific memory CD4<sup>+</sup>
T cells could be also recalled after the secondary challenge, while the antibody levels were unaffected. This provides evidence that long-term memory T cells can be generated during an oseltamivir-interrupted infection. The anti-inflammatory effect of oseltamivir was verified in H1N1-infected patients. Thus, in the case of an unpredicted influenza pandemic, while prophylactic oseltamivir treatment can reduce disease severity, the capacity to generate memory CD8<sup>+</sup>
T cells specific for the newly emerged virus is uncompromised. This could prove especially important for any new influenza pandemic which often occurs in separate waves.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kreijtz, Jhcm" uniqKey="Kreijtz J">JHCM Kreijtz</name>
</author>
<author><name sortKey="Fouchier, Ram" uniqKey="Fouchier R">RAM Fouchier</name>
</author>
<author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Herfst, S" uniqKey="Herfst S">S Herfst</name>
</author>
<author><name sortKey="Schrauwen, Ej" uniqKey="Schrauwen E">EJ Schrauwen</name>
</author>
<author><name sortKey="Linster, M" uniqKey="Linster M">M Linster</name>
</author>
<author><name sortKey="Chutinimitkul, S" uniqKey="Chutinimitkul S">S Chutinimitkul</name>
</author>
<author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gao, R" uniqKey="Gao R">R Gao</name>
</author>
<author><name sortKey="Cao, B" uniqKey="Cao B">B Cao</name>
</author>
<author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name>
</author>
<author><name sortKey="Feng, Z" uniqKey="Feng Z">Z Feng</name>
</author>
<author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name>
</author>
<author><name sortKey="Hu, W" uniqKey="Hu W">W Hu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name>
</author>
<author><name sortKey="Zhou, L" uniqKey="Zhou L">L Zhou</name>
</author>
<author><name sortKey="Zhou, M" uniqKey="Zhou M">M Zhou</name>
</author>
<author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name>
</author>
<author><name sortKey="Li, F" uniqKey="Li F">F Li</name>
</author>
<author><name sortKey="Hu, W" uniqKey="Hu W">W Hu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Zhang, A" uniqKey="Zhang A">A Zhang</name>
</author>
<author><name sortKey="Wan, Y" uniqKey="Wan Y">Y Wan</name>
</author>
<author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name>
</author>
<author><name sortKey="Qiu, C" uniqKey="Qiu C">C Qiu</name>
</author>
<author><name sortKey="Xi, X" uniqKey="Xi X">X Xi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hurt, Ac" uniqKey="Hurt A">AC Hurt</name>
</author>
<author><name sortKey="Ho, Ht" uniqKey="Ho H">HT Ho</name>
</author>
<author><name sortKey="Barr, I" uniqKey="Barr I">I Barr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name>
</author>
<author><name sortKey="Topham, Dj" uniqKey="Topham D">DJ Topham</name>
</author>
<author><name sortKey="Tripp, Ra" uniqKey="Tripp R">RA Tripp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kreijtz, Jh" uniqKey="Kreijtz J">JH Kreijtz</name>
</author>
<author><name sortKey="De Mutsert, G" uniqKey="De Mutsert G">G de Mutsert</name>
</author>
<author><name sortKey="Van Baalen, Ca" uniqKey="Van Baalen C">CA van Baalen</name>
</author>
<author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name>
</author>
<author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name>
</author>
<author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Ly" uniqKey="Lee L">LY Lee</name>
</author>
<author><name sortKey="Ha Do, La" uniqKey="Ha Do L">LA Ha do</name>
</author>
<author><name sortKey="Simmons, C" uniqKey="Simmons C">C Simmons</name>
</author>
<author><name sortKey="De Jong, Md" uniqKey="De Jong M">MD de Jong</name>
</author>
<author><name sortKey="Chau, Nv" uniqKey="Chau N">NV Chau</name>
</author>
<author><name sortKey="Schumacher, R" uniqKey="Schumacher R">R Schumacher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gras, S" uniqKey="Gras S">S Gras</name>
</author>
<author><name sortKey="Kedzierski, L" uniqKey="Kedzierski L">L Kedzierski</name>
</author>
<author><name sortKey="Valkenburg, Sa" uniqKey="Valkenburg S">SA Valkenburg</name>
</author>
<author><name sortKey="Laurie, K" uniqKey="Laurie K">K Laurie</name>
</author>
<author><name sortKey="Liu, Yc" uniqKey="Liu Y">YC Liu</name>
</author>
<author><name sortKey="Denholm, Jt" uniqKey="Denholm J">JT Denholm</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sridhar, S" uniqKey="Sridhar S">S Sridhar</name>
</author>
<author><name sortKey="Begom, S" uniqKey="Begom S">S Begom</name>
</author>
<author><name sortKey="Bermingham, A" uniqKey="Bermingham A">A Bermingham</name>
</author>
<author><name sortKey="Hoschler, K" uniqKey="Hoschler K">K Hoschler</name>
</author>
<author><name sortKey="Adamson, W" uniqKey="Adamson W">W Adamson</name>
</author>
<author><name sortKey="Carman, W" uniqKey="Carman W">W Carman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Quinones Parra, S" uniqKey="Quinones Parra S">S Quinones-Parra</name>
</author>
<author><name sortKey="Grant, E" uniqKey="Grant E">E Grant</name>
</author>
<author><name sortKey="Loh, L" uniqKey="Loh L">L Loh</name>
</author>
<author><name sortKey="Nguyen, Th" uniqKey="Nguyen T">TH Nguyen</name>
</author>
<author><name sortKey="Campbell, Ka" uniqKey="Campbell K">KA Campbell</name>
</author>
<author><name sortKey="Tong, Sy" uniqKey="Tong S">SY Tong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van De Sandt, Ce" uniqKey="Van De Sandt C">CE van de Sandt</name>
</author>
<author><name sortKey="Kreijtz, Jh" uniqKey="Kreijtz J">JH Kreijtz</name>
</author>
<author><name sortKey="De Mutsert, G" uniqKey="De Mutsert G">G de Mutsert</name>
</author>
<author><name sortKey="Geelhoed Mieras, Mm" uniqKey="Geelhoed Mieras M">MM Geelhoed-Mieras</name>
</author>
<author><name sortKey="Hillaire, Ml" uniqKey="Hillaire M">ML Hillaire</name>
</author>
<author><name sortKey="Vogelzang Van Trierum, Se" uniqKey="Vogelzang Van Trierum S">SE Vogelzang-van Trierum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Greenbaum, Ja" uniqKey="Greenbaum J">JA Greenbaum</name>
</author>
<author><name sortKey="Kotturi, Mf" uniqKey="Kotturi M">MF Kotturi</name>
</author>
<author><name sortKey="Kim, Y" uniqKey="Kim Y">Y Kim</name>
</author>
<author><name sortKey="Oseroff, C" uniqKey="Oseroff C">C Oseroff</name>
</author>
<author><name sortKey="Vaughan, K" uniqKey="Vaughan K">K Vaughan</name>
</author>
<author><name sortKey="Salimi, N" uniqKey="Salimi N">N Salimi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Croom, Ha" uniqKey="Croom H">HA Croom</name>
</author>
<author><name sortKey="Denton, Ae" uniqKey="Denton A">AE Denton</name>
</author>
<author><name sortKey="Valkenburg, Sa" uniqKey="Valkenburg S">SA Valkenburg</name>
</author>
<author><name sortKey="Swan, Ng" uniqKey="Swan N">NG Swan</name>
</author>
<author><name sortKey="Olson, Mr" uniqKey="Olson M">MR Olson</name>
</author>
<author><name sortKey="Turner, Sj" uniqKey="Turner S">SJ Turner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Valkenburg, Sa" uniqKey="Valkenburg S">SA Valkenburg</name>
</author>
<author><name sortKey="Rutigliano, Ja" uniqKey="Rutigliano J">JA Rutigliano</name>
</author>
<author><name sortKey="Ellebedy, Ah" uniqKey="Ellebedy A">AH Ellebedy</name>
</author>
<author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name>
</author>
<author><name sortKey="Thomas, Pg" uniqKey="Thomas P">PG Thomas</name>
</author>
<author><name sortKey="Kedzierska, K" uniqKey="Kedzierska K">K Kedzierska</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kedzierska, K" uniqKey="Kedzierska K">K Kedzierska</name>
</author>
<author><name sortKey="Venturi, V" uniqKey="Venturi V">V Venturi</name>
</author>
<author><name sortKey="Field, K" uniqKey="Field K">K Field</name>
</author>
<author><name sortKey="Davenport, Mp" uniqKey="Davenport M">MP Davenport</name>
</author>
<author><name sortKey="Turner, Sj" uniqKey="Turner S">SJ Turner</name>
</author>
<author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kedzierska, K" uniqKey="Kedzierska K">K Kedzierska</name>
</author>
<author><name sortKey="Stambas, J" uniqKey="Stambas J">J Stambas</name>
</author>
<author><name sortKey="Jenkins, Mr" uniqKey="Jenkins M">MR Jenkins</name>
</author>
<author><name sortKey="Keating, R" uniqKey="Keating R">R Keating</name>
</author>
<author><name sortKey="Turner, Sj" uniqKey="Turner S">SJ Turner</name>
</author>
<author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kedzierska, K" uniqKey="Kedzierska K">K Kedzierska</name>
</author>
<author><name sortKey="Valkenburg, Sa" uniqKey="Valkenburg S">SA Valkenburg</name>
</author>
<author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name>
</author>
<author><name sortKey="Davenport, Mp" uniqKey="Davenport M">MP Davenport</name>
</author>
<author><name sortKey="Venturi, V" uniqKey="Venturi V">V Venturi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oshansky, Cm" uniqKey="Oshansky C">CM Oshansky</name>
</author>
<author><name sortKey="Gartland, Aj" uniqKey="Gartland A">AJ Gartland</name>
</author>
<author><name sortKey="Wong, Ss" uniqKey="Wong S">SS Wong</name>
</author>
<author><name sortKey="Jeevan, T" uniqKey="Jeevan T">T Jeevan</name>
</author>
<author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name>
</author>
<author><name sortKey="Roddam, Pl" uniqKey="Roddam P">PL Roddam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="La Gruta, Nl" uniqKey="La Gruta N">NL La Gruta</name>
</author>
<author><name sortKey="Turner, Sj" uniqKey="Turner S">SJ Turner</name>
</author>
<author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Epstein, Sl" uniqKey="Epstein S">SL Epstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Ly H" uniqKey="Lee L">LY-H Lee</name>
</author>
<author><name sortKey="Ha, Dla" uniqKey="Ha D">DLA Ha</name>
</author>
<author><name sortKey="Simmons, C" uniqKey="Simmons C">C Simmons</name>
</author>
<author><name sortKey="De Jong, Md" uniqKey="De Jong M">MD de Jong</name>
</author>
<author><name sortKey="Chau, Nvv" uniqKey="Chau N">NVV Chau</name>
</author>
<author><name sortKey="Schumacher, R" uniqKey="Schumacher R">R Schumacher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Assarsson, E" uniqKey="Assarsson E">E Assarsson</name>
</author>
<author><name sortKey="Bui, Hh" uniqKey="Bui H">HH Bui</name>
</author>
<author><name sortKey="Sidney, J" uniqKey="Sidney J">J Sidney</name>
</author>
<author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name>
</author>
<author><name sortKey="Glenn, J" uniqKey="Glenn J">J Glenn</name>
</author>
<author><name sortKey="Oseroff, C" uniqKey="Oseroff C">C Oseroff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bender, Bs" uniqKey="Bender B">BS Bender</name>
</author>
<author><name sortKey="Croghan, T" uniqKey="Croghan T">T Croghan</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name>
</author>
<author><name sortKey="Small, Pa" uniqKey="Small P">PA Small</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcmichael, Aj" uniqKey="Mcmichael A">AJ McMichael</name>
</author>
<author><name sortKey="Gotch, Fm" uniqKey="Gotch F">FM Gotch</name>
</author>
<author><name sortKey="Noble, Gr" uniqKey="Noble G">GR Noble</name>
</author>
<author><name sortKey="Beare, Pa" uniqKey="Beare P">PA Beare</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ilyushina, Na" uniqKey="Ilyushina N">NA Ilyushina</name>
</author>
<author><name sortKey="Hay, A" uniqKey="Hay A">A Hay</name>
</author>
<author><name sortKey="Yilmaz, N" uniqKey="Yilmaz N">N Yilmaz</name>
</author>
<author><name sortKey="Boon, Ac" uniqKey="Boon A">AC Boon</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="La Gruta, Nl" uniqKey="La Gruta N">NL La Gruta</name>
</author>
<author><name sortKey="Kedzierska, K" uniqKey="Kedzierska K">K Kedzierska</name>
</author>
<author><name sortKey="Stambas, J" uniqKey="Stambas J">J Stambas</name>
</author>
<author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oh, Dy" uniqKey="Oh D">DY Oh</name>
</author>
<author><name sortKey="Lowther, S" uniqKey="Lowther S">S Lowther</name>
</author>
<author><name sortKey="Mccaw, Jm" uniqKey="Mccaw J">JM McCaw</name>
</author>
<author><name sortKey="Sullivan, Sg" uniqKey="Sullivan S">SG Sullivan</name>
</author>
<author><name sortKey="Leang, Sk" uniqKey="Leang S">SK Leang</name>
</author>
<author><name sortKey="Haining, J" uniqKey="Haining J">J Haining</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Manicassamy, B" uniqKey="Manicassamy B">B Manicassamy</name>
</author>
<author><name sortKey="Manicassamy, S" uniqKey="Manicassamy S">S Manicassamy</name>
</author>
<author><name sortKey="Belicha Villanueva, A" uniqKey="Belicha Villanueva A">A Belicha-Villanueva</name>
</author>
<author><name sortKey="Pisanelli, G" uniqKey="Pisanelli G">G Pisanelli</name>
</author>
<author><name sortKey="Pulendran, B" uniqKey="Pulendran B">B Pulendran</name>
</author>
<author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A Garcia-Sastre</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gubareva, Lv" uniqKey="Gubareva L">LV Gubareva</name>
</author>
<author><name sortKey="Bethell, R" uniqKey="Bethell R">R Bethell</name>
</author>
<author><name sortKey="Hart, Gj" uniqKey="Hart G">GJ Hart</name>
</author>
<author><name sortKey="Murti, Kg" uniqKey="Murti K">KG Murti</name>
</author>
<author><name sortKey="Penn, Cr" uniqKey="Penn C">CR Penn</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Badovinac, Vp" uniqKey="Badovinac V">VP Badovinac</name>
</author>
<author><name sortKey="Porter, Bb" uniqKey="Porter B">BB Porter</name>
</author>
<author><name sortKey="Harty, Jt" uniqKey="Harty J">JT Harty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kedzierska, K" uniqKey="Kedzierska K">K Kedzierska</name>
</author>
<author><name sortKey="Venturi, V" uniqKey="Venturi V">V Venturi</name>
</author>
<author><name sortKey="Valkenburg, Sa" uniqKey="Valkenburg S">SA Valkenburg</name>
</author>
<author><name sortKey="Davenport, Mp" uniqKey="Davenport M">MP Davenport</name>
</author>
<author><name sortKey="Turner, Sj" uniqKey="Turner S">SJ Turner</name>
</author>
<author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Joshi, Ns" uniqKey="Joshi N">NS Joshi</name>
</author>
<author><name sortKey="Cui, W" uniqKey="Cui W">W Cui</name>
</author>
<author><name sortKey="Chandele, A" uniqKey="Chandele A">A Chandele</name>
</author>
<author><name sortKey="Lee, Hk" uniqKey="Lee H">HK Lee</name>
</author>
<author><name sortKey="Urso, Dr" uniqKey="Urso D">DR Urso</name>
</author>
<author><name sortKey="Hagman, J" uniqKey="Hagman J">J Hagman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kalia, V" uniqKey="Kalia V">V Kalia</name>
</author>
<author><name sortKey="Sarkar, S" uniqKey="Sarkar S">S Sarkar</name>
</author>
<author><name sortKey="Subramaniam, S" uniqKey="Subramaniam S">S Subramaniam</name>
</author>
<author><name sortKey="Haining, Wn" uniqKey="Haining W">WN Haining</name>
</author>
<author><name sortKey="Smith, Ka" uniqKey="Smith K">KA Smith</name>
</author>
<author><name sortKey="Ahmed, R" uniqKey="Ahmed R">R Ahmed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ilyushina, Na" uniqKey="Ilyushina N">NA Ilyushina</name>
</author>
<author><name sortKey="Hay, A" uniqKey="Hay A">A Hay</name>
</author>
<author><name sortKey="Yilmaz, N" uniqKey="Yilmaz N">N Yilmaz</name>
</author>
<author><name sortKey="Boon, Ac" uniqKey="Boon A">AC Boon</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
<author><name sortKey="Govorkova, Ea" uniqKey="Govorkova E">EA Govorkova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Olson, Mr" uniqKey="Olson M">MR Olson</name>
</author>
<author><name sortKey="Seah, Sg" uniqKey="Seah S">SG Seah</name>
</author>
<author><name sortKey="Cullen, J" uniqKey="Cullen J">J Cullen</name>
</author>
<author><name sortKey="Greyer, M" uniqKey="Greyer M">M Greyer</name>
</author>
<author><name sortKey="Edenborough, K" uniqKey="Edenborough K">K Edenborough</name>
</author>
<author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oh, Dy" uniqKey="Oh D">DY Oh</name>
</author>
<author><name sortKey="Barr, Ig" uniqKey="Barr I">IG Barr</name>
</author>
<author><name sortKey="Hurt, Ac" uniqKey="Hurt A">AC Hurt</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>États-Unis</li>
</country>
<region><li>Géorgie (États-Unis)</li>
<li>Tennessee</li>
<li>Victoria (État)</li>
</region>
<settlement><li>Melbourne</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Bird, Nicola L" sort="Bird, Nicola L" uniqKey="Bird N" first="Nicola L." last="Bird">Nicola L. Bird</name>
</region>
<name sortKey="Chua, Brendon Y" sort="Chua, Brendon Y" uniqKey="Chua B" first="Brendon Y." last="Chua">Brendon Y. Chua</name>
<name sortKey="Hurt, Aeron C" sort="Hurt, Aeron C" uniqKey="Hurt A" first="Aeron C." last="Hurt">Aeron C. Hurt</name>
<name sortKey="Hurt, Aeron C" sort="Hurt, Aeron C" uniqKey="Hurt A" first="Aeron C." last="Hurt">Aeron C. Hurt</name>
<name sortKey="Jackson, David C" sort="Jackson, David C" uniqKey="Jackson D" first="David C." last="Jackson">David C. Jackson</name>
<name sortKey="Kedzierska, Katherine" sort="Kedzierska, Katherine" uniqKey="Kedzierska K" first="Katherine" last="Kedzierska">Katherine Kedzierska</name>
<name sortKey="Oh, Ding Yuan" sort="Oh, Ding Yuan" uniqKey="Oh D" first="Ding Yuan" last="Oh">Ding Yuan Oh</name>
<name sortKey="Oh, Ding Yuan" sort="Oh, Ding Yuan" uniqKey="Oh D" first="Ding Yuan" last="Oh">Ding Yuan Oh</name>
<name sortKey="Olson, Matthew R" sort="Olson, Matthew R" uniqKey="Olson M" first="Matthew R." last="Olson">Matthew R. Olson</name>
<name sortKey="Reading, Patrick C" sort="Reading, Patrick C" uniqKey="Reading P" first="Patrick C." last="Reading">Patrick C. Reading</name>
<name sortKey="Reading, Patrick C" sort="Reading, Patrick C" uniqKey="Reading P" first="Patrick C." last="Reading">Patrick C. Reading</name>
<name sortKey="Turner, Stephen J" sort="Turner, Stephen J" uniqKey="Turner S" first="Stephen J." last="Turner">Stephen J. Turner</name>
</country>
<country name="États-Unis"><region name="Tennessee"><name sortKey="Oshansky, Christine M" sort="Oshansky, Christine M" uniqKey="Oshansky C" first="Christine M." last="Oshansky">Christine M. Oshansky</name>
</region>
<name sortKey="Handel, Andreas" sort="Handel, Andreas" uniqKey="Handel A" first="Andreas" last="Handel">Andreas Handel</name>
<name sortKey="Sun, Yilun" sort="Sun, Yilun" uniqKey="Sun Y" first="Yilun" last="Sun">Yilun Sun</name>
<name sortKey="Tang, Li" sort="Tang, Li" uniqKey="Tang L" first="Li" last="Tang">Li Tang</name>
<name sortKey="Thomas, Paul G" sort="Thomas, Paul G" uniqKey="Thomas P" first="Paul G." last="Thomas">Paul G. Thomas</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B85 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 000B85 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= PMC:4473273 |texte= Oseltamivir Prophylaxis Reduces Inflammation and Facilitates Establishment of Cross-Strain Protective T Cell Memory to Influenza Viruses }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:26086392" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a H2N2V1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |