Assessing the fitness of distinct clades of influenza A (H9N2) viruses
Identifieur interne : 000B72 ( Ncbi/Checkpoint ); précédent : 000B71; suivant : 000B73Assessing the fitness of distinct clades of influenza A (H9N2) viruses
Auteurs :Source :
- Emerging Microbes & Infections [ 2222-1751 ] ; 2013.
Abstract
Influenza A (H9N2) viruses are a genetically diverse population that infects wild and domestic avian species and mammals and contributed the internal gene segments to the A/H5N1 and A/H7N9 viruses associated with lethal human infections. Here we comprehensively assess the potential risk to mammals of a diverse panel of A/H9N2 viruses, representing the major H9N2 clades, using a combination of
Url:
DOI: 10.1038/emi.2013.75
PubMed: 26038443
PubMed Central: 3924558
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessing the fitness of distinct clades of influenza A (H9N2) viruses</title></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26038443</idno><idno type="pmc">3924558</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924558</idno><idno type="RBID">PMC:3924558</idno><idno type="doi">10.1038/emi.2013.75</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000001</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000001</idno><idno type="wicri:Area/Pmc/Curation">000001</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000001</idno><idno type="wicri:Area/Pmc/Checkpoint">000647</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000647</idno><idno type="wicri:Area/Ncbi/Merge">000B72</idno><idno type="wicri:Area/Ncbi/Curation">000B72</idno><idno type="wicri:Area/Ncbi/Checkpoint">000B72</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Assessing the fitness of distinct clades of influenza A (H9N2) viruses</title></analytic><series><title level="j">Emerging Microbes & Infections</title><idno type="eISSN">2222-1751</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza A (H9N2) viruses are a genetically diverse population that infects wild and domestic avian species and mammals and contributed the internal gene segments to the A/H5N1 and A/H7N9 viruses associated with lethal human infections. Here we comprehensively assess the potential risk to mammals of a diverse panel of A/H9N2 viruses, representing the major H9N2 clades, using a combination of <italic>in vitro</italic> assays (e.g., antiviral susceptibility and virus growth in primary differentiated human airway cells) and <italic>in vivo</italic> assays (e.g., replication, transmission and/or pathogenicity of viruses in ducks, pigs, mice and ferrets). We observed that viruses isolated from humans, A/Hong Kong/1073/1999 and A/Hong Kong/33982/2009, had the highest risk potential. However, the A/swine/Hong Kong/9A-1/1998 and A/chicken/Hong Kong/G9/1997 viruses also displayed several features suggesting a fitness profile adapted to human infection and transmission. The North American avian H9N2 clade virus had the lowest risk profile, and the other viruses tested displayed various levels of fitness across individual assays. In many cases, the known genotypic polymorphisms alone were not sufficient to accurately predict the virus' phenotype. Therefore, we conclude that comprehensive risk analyses based on surveillance of circulating influenza virus strains are necessary to assess the potential for human infection by emerging influenza A viruses.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author><author><name sortKey="Zhou, L" uniqKey="Zhou L">L Zhou</name></author><author><name sortKey="Zhou, M" uniqKey="Zhou M">M Zhou</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Uyeki, Tm" uniqKey="Uyeki T">TM Uyeki</name></author><author><name sortKey="Nguyen, Dc" uniqKey="Nguyen D">DC Nguyen</name></author><author><name sortKey="Rowe, T" uniqKey="Rowe T">T Rowe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author><author><name sortKey="Chan, Jf" uniqKey="Chan J">JF 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