Influenza A Virus Entry Inhibitors Targeting the Hemagglutinin
Identifieur interne : 000863 ( Ncbi/Checkpoint ); précédent : 000862; suivant : 000864Influenza A Virus Entry Inhibitors Targeting the Hemagglutinin
Auteurs : Jie Yang ; Minmin Li ; Xintian Shen ; Shuwen LiuSource :
- Viruses [ 1999-4915 ] ; 2013.
Abstract
Influenza A virus (IAV) has caused seasonal influenza epidemics and influenza pandemics, which resulted in serious threat to public health and socioeconomic impacts. Until now, only 5 drugs belong to two categories are used for prophylaxis and treatment of IAV infection. Hemagglutinin (HA), the envelope glycoprotein of IAV, plays a critical role in viral binding, fusion and entry. Therefore, HA is an attractive target for developing anti‑IAV drugs to block the entry step of IAV infection. Here we reviewed the recent progress in the study of conformational changes of HA during viral fusion process and the development of HA-based IAV entry inhibitors, which may provide a new choice for controlling future influenza pandemics.
Url:
DOI: 10.3390/v5010352
PubMed: 23340380
PubMed Central: 3564125
Affiliations:
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<author><name sortKey="Li, Minmin" sort="Li, Minmin" uniqKey="Li M" first="Minmin" last="Li">Minmin Li</name>
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<front><div type="abstract" xml:lang="en"><p>Influenza A virus (IAV) has caused seasonal influenza epidemics and influenza pandemics, which resulted in serious threat to public health and socioeconomic impacts. Until now, only 5 drugs belong to two categories are used for prophylaxis and treatment of IAV infection. Hemagglutinin (HA), the envelope glycoprotein of IAV, plays a critical role in viral binding, fusion and entry. Therefore, HA is an attractive target for developing anti‑IAV drugs to block the entry step of IAV infection. Here we reviewed the recent progress in the study of conformational changes of HA during viral fusion process and the development of HA-based IAV entry inhibitors, which may provide a new choice for controlling future influenza pandemics.</p>
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<tree><noCountry><name sortKey="Li, Minmin" sort="Li, Minmin" uniqKey="Li M" first="Minmin" last="Li">Minmin Li</name>
<name sortKey="Liu, Shuwen" sort="Liu, Shuwen" uniqKey="Liu S" first="Shuwen" last="Liu">Shuwen Liu</name>
<name sortKey="Shen, Xintian" sort="Shen, Xintian" uniqKey="Shen X" first="Xintian" last="Shen">Xintian Shen</name>
<name sortKey="Yang, Jie" sort="Yang, Jie" uniqKey="Yang J" first="Jie" last="Yang">Jie Yang</name>
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