Mixed influenza A and B infections complicate the detection of influenza viruses with altered sensitivities to neuraminidase inhibitors.
Identifieur interne : 000648 ( Ncbi/Checkpoint ); précédent : 000647; suivant : 000649Mixed influenza A and B infections complicate the detection of influenza viruses with altered sensitivities to neuraminidase inhibitors.
Auteurs : Peter G. Mohr [Australie] ; Henriette Geyer ; Jennifer L. Mckimm-BreschkinSource :
- Antiviral research [ 1872-9096 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Antienzymes (pharmacologie), Antienzymes (usage thérapeutique), Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Chiens, Grippe humaine (diagnostic), Grippe humaine (sang), Grippe humaine (virologie), Humains, Lignée cellulaire, Oséltamivir (pharmacologie), Oséltamivir (usage thérapeutique), Résistance virale aux médicaments, Sialidase (antagonistes et inhibiteurs), Sous-type H2N2 du virus de la grippe A (isolement et purification), Virus influenza B (isolement et purification), Zanamivir (pharmacologie), Zanamivir (usage thérapeutique).
- MESH :
- antagonistes et inhibiteurs : Sialidase.
- diagnostic : Grippe humaine.
- isolement et purification : Sous-type H2N2 du virus de la grippe A, Virus influenza B.
- pharmacologie : Antienzymes, Antiviraux, Oséltamivir, Zanamivir.
- sang : Grippe humaine.
- usage thérapeutique : Antienzymes, Antiviraux, Oséltamivir, Zanamivir.
- virologie : Grippe humaine.
- Animaux, Chiens, Humains, Lignée cellulaire, Résistance virale aux médicaments.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Cell Line, Dogs, Drug Resistance, Viral, Enzyme Inhibitors (pharmacology), Enzyme Inhibitors (therapeutic use), Humans, Influenza A Virus, H2N2 Subtype (isolation & purification), Influenza B virus (isolation & purification), Influenza, Human (blood), Influenza, Human (diagnosis), Influenza, Human (virology), Neuraminidase (antagonists & inhibitors), Oseltamivir (pharmacology), Oseltamivir (therapeutic use), Zanamivir (pharmacology), Zanamivir (therapeutic use).
- MESH :
- chemical , antagonists & inhibitors : Neuraminidase.
- chemical , pharmacology : Antiviral Agents, Enzyme Inhibitors, Oseltamivir, Zanamivir.
- chemical , therapeutic use : Antiviral Agents, Enzyme Inhibitors, Oseltamivir, Zanamivir.
- blood : Influenza, Human.
- diagnosis : Influenza, Human.
- isolation & purification : Influenza A Virus, H2N2 Subtype, Influenza B virus.
- virology : Influenza, Human.
- Animals, Cell Line, Dogs, Drug Resistance, Viral, Humans.
Abstract
Previously, three influenza A(H3N2) isolates with a reduced susceptibility to the neuraminidase inhibitors (NAIs) zanamivir and oseltamivir were identified during screening by the Neuraminidase Inhibitor Susceptibility Network (NISN). The isolates were from untreated patients from the first three years post licensure of the NAIs. We plaque-purified progeny from each of these isolates and determined the NAI sensitivity of each plaqued population. Sequencing and serology for each population revealed that the isolates contained a mix of wild type influenza A(H3N2) and influenza B. The NAI susceptibility reductions that had originally been reported were a consequence of influenza B neuraminidases that have lower relative NAI sensitivities, rather than being due to resistant influenza A(H3N2) viruses. Our study highlights the need to check for mixed influenza infections when isolates with potentially lower sensitivities to NAIs are identified.
DOI: 10.1016/j.antiviral.2011.04.010
PubMed: 21549758
Affiliations:
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pubmed:21549758Le document en format XML
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<author><name sortKey="Mohr, Peter G" sort="Mohr, Peter G" uniqKey="Mohr P" first="Peter G" last="Mohr">Peter G. Mohr</name>
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<wicri:regionArea>CSIRO Livestock Industries, Australian Animal Health Laboratory (AAHL), Private Bag, Geelong VIC</wicri:regionArea>
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<author><name sortKey="Mckimm Breschkin, Jennifer L" sort="Mckimm Breschkin, Jennifer L" uniqKey="Mckimm Breschkin J" first="Jennifer L" last="Mckimm-Breschkin">Jennifer L. Mckimm-Breschkin</name>
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<series><title level="j">Antiviral research</title>
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<term>Cell Line</term>
<term>Dogs</term>
<term>Drug Resistance, Viral</term>
<term>Enzyme Inhibitors (pharmacology)</term>
<term>Enzyme Inhibitors (therapeutic use)</term>
<term>Humans</term>
<term>Influenza A Virus, H2N2 Subtype (isolation & purification)</term>
<term>Influenza B virus (isolation & purification)</term>
<term>Influenza, Human (blood)</term>
<term>Influenza, Human (diagnosis)</term>
<term>Influenza, Human (virology)</term>
<term>Neuraminidase (antagonists & inhibitors)</term>
<term>Oseltamivir (pharmacology)</term>
<term>Oseltamivir (therapeutic use)</term>
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<term>Zanamivir (therapeutic use)</term>
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<term>Antienzymes (pharmacologie)</term>
<term>Antienzymes (usage thérapeutique)</term>
<term>Antiviraux (pharmacologie)</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>Chiens</term>
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<term>Grippe humaine (sang)</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Oséltamivir (pharmacologie)</term>
<term>Oséltamivir (usage thérapeutique)</term>
<term>Résistance virale aux médicaments</term>
<term>Sialidase (antagonistes et inhibiteurs)</term>
<term>Sous-type H2N2 du virus de la grippe A (isolement et purification)</term>
<term>Virus influenza B (isolement et purification)</term>
<term>Zanamivir (pharmacologie)</term>
<term>Zanamivir (usage thérapeutique)</term>
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<term>Enzyme Inhibitors</term>
<term>Oseltamivir</term>
<term>Zanamivir</term>
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<term>Virus influenza B</term>
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<term>Antiviraux</term>
<term>Oséltamivir</term>
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<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antienzymes</term>
<term>Antiviraux</term>
<term>Oséltamivir</term>
<term>Zanamivir</term>
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<term>Dogs</term>
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<front><div type="abstract" xml:lang="en">Previously, three influenza A(H3N2) isolates with a reduced susceptibility to the neuraminidase inhibitors (NAIs) zanamivir and oseltamivir were identified during screening by the Neuraminidase Inhibitor Susceptibility Network (NISN). The isolates were from untreated patients from the first three years post licensure of the NAIs. We plaque-purified progeny from each of these isolates and determined the NAI sensitivity of each plaqued population. Sequencing and serology for each population revealed that the isolates contained a mix of wild type influenza A(H3N2) and influenza B. The NAI susceptibility reductions that had originally been reported were a consequence of influenza B neuraminidases that have lower relative NAI sensitivities, rather than being due to resistant influenza A(H3N2) viruses. Our study highlights the need to check for mixed influenza infections when isolates with potentially lower sensitivities to NAIs are identified.</div>
</front>
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<tree><noCountry><name sortKey="Geyer, Henriette" sort="Geyer, Henriette" uniqKey="Geyer H" first="Henriette" last="Geyer">Henriette Geyer</name>
<name sortKey="Mckimm Breschkin, Jennifer L" sort="Mckimm Breschkin, Jennifer L" uniqKey="Mckimm Breschkin J" first="Jennifer L" last="Mckimm-Breschkin">Jennifer L. Mckimm-Breschkin</name>
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