Conserved amino acid markers from past influenza pandemic strains
Identifieur interne : 000359 ( Ncbi/Checkpoint ); précédent : 000358; suivant : 000360Conserved amino acid markers from past influenza pandemic strains
Auteurs : Jonathan E. Allen [États-Unis] ; Shea N. Gardner [États-Unis] ; Elizabeth A. Vitalis [États-Unis] ; Tom R. Slezak [États-Unis]Source :
- BMC Microbiology [ 1471-2180 ] ; 2009.
Abstract
Finding the amino acid mutations that affect the severity of influenza infections remains an open and challenging problem. Of special interest is better understanding how current circulating influenza strains could evolve into a new pandemic strain. Influenza proteomes from distinct viral phenotype classes were searched for class specific amino acid mutations conserved in past pandemics, using reverse engineered linear classifiers.
Thirty-four amino acid markers associated with host specificity and high mortality rate were found. Some markers had little impact on distinguishing the functional classes by themselves, however in combination with other mutations they improved class prediction. Pairwise combinations of influenza genomes were checked for reassortment and mutation events needed to acquire the pandemic conserved markers. Evolutionary pathways involving H1N1 human and swine strains mixed with avian strains show the potential to acquire the pandemic markers with a double reassortment and one or two amino acid mutations.
The small mutation combinations found at multiple protein positions associated with viral phenotype indicate that surveillance tools could monitor genetic variation beyond single point mutations to track influenza strains. Finding that certain strain combinations have the potential to acquire pandemic conserved markers through a limited number of reassortment and mutation events illustrates the potential for reassortment and mutation events to lead to new circulating influenza strains.
Url:
DOI: 10.1186/1471-2180-9-77
PubMed: 19386124
PubMed Central: 2685398
Affiliations:
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PMC:2685398Le document en format XML
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Finding the amino acid mutations that affect the severity of influenza infections remains an open and challenging problem. Of special interest is better understanding how current circulating influenza strains could evolve into a new pandemic strain. Influenza proteomes from distinct viral phenotype classes were searched for class specific amino acid mutations conserved in past pandemics, using reverse engineered linear classifiers.</p>
</sec>
<sec><title>Results</title>
<p>Thirty-four amino acid markers associated with host specificity and high mortality rate were found. Some markers had little impact on distinguishing the functional classes by themselves, however in combination with other mutations they improved class prediction. Pairwise combinations of influenza genomes were checked for reassortment and mutation events needed to acquire the pandemic conserved markers. Evolutionary pathways involving H1N1 human and swine strains mixed with avian strains show the potential to acquire the pandemic markers with a double reassortment and one or two amino acid mutations.</p>
</sec>
<sec><title>Conclusion</title>
<p>The small mutation combinations found at multiple protein positions associated with viral phenotype indicate that surveillance tools could monitor genetic variation beyond single point mutations to track influenza strains. Finding that certain strain combinations have the potential to acquire pandemic conserved markers through a limited number of reassortment and mutation events illustrates the potential for reassortment and mutation events to lead to new circulating influenza strains.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Rabadan, R" uniqKey="Rabadan R">R Rabadan</name>
</author>
<author><name sortKey="Levine, Aj" uniqKey="Levine A">AJ Levine</name>
</author>
<author><name sortKey="Robins, H" uniqKey="Robins H">H Robins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wong, Ssy" uniqKey="Wong S">SSY Wong</name>
</author>
<author><name sortKey="Yuen, Ky" uniqKey="Yuen K">Ky Yuen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Auewarakul, P" uniqKey="Auewarakul P">P Auewarakul</name>
</author>
<author><name sortKey="Suptawiwat, O" uniqKey="Suptawiwat O">O Suptawiwat</name>
</author>
<author><name sortKey="Kongchanagul, A" uniqKey="Kongchanagul A">A Kongchanagul</name>
</author>
<author><name sortKey="Sangma, C" uniqKey="Sangma C">C Sangma</name>
</author>
<author><name sortKey="Suzuki, Y" uniqKey="Suzuki Y">Y Suzuki</name>
</author>
<author><name sortKey="Ungchusak, K" uniqKey="Ungchusak K">K Ungchusak</name>
</author>
<author><name sortKey="Louisirirotchanakul, S" uniqKey="Louisirirotchanakul S">S Louisirirotchanakul</name>
</author>
<author><name sortKey="Lerdsamran, H" uniqKey="Lerdsamran H">H Lerdsamran</name>
</author>
<author><name sortKey="Pooruk, P" uniqKey="Pooruk P">P Pooruk</name>
</author>
<author><name sortKey="Thitithanyanont, A" uniqKey="Thitithanyanont A">A Thitithanyanont</name>
</author>
<author><name sortKey="Pittayawonganon, C" uniqKey="Pittayawonganon C">C Pittayawonganon</name>
</author>
<author><name sortKey="Guo, Ct" uniqKey="Guo C">CT Guo</name>
</author>
<author><name sortKey="Hiramatsu, H" uniqKey="Hiramatsu H">H Hiramatsu</name>
</author>
<author><name sortKey="Jampangern, W" uniqKey="Jampangern W">W Jampangern</name>
</author>
<author><name sortKey="Chunsutthiwat, S" uniqKey="Chunsutthiwat S">S Chunsutthiwat</name>
</author>
<author><name sortKey="Puthavathana, P" uniqKey="Puthavathana P">P Puthavathana</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hatta, M" uniqKey="Hatta M">M Hatta</name>
</author>
<author><name sortKey="Hatta, Y" uniqKey="Hatta Y">Y Hatta</name>
</author>
<author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name>
</author>
<author><name sortKey="Watanabe, S" uniqKey="Watanabe S">S Watanabe</name>
</author>
<author><name sortKey="Shinya, K" uniqKey="Shinya K">K Shinya</name>
</author>
<author><name sortKey="Nguye N, T" uniqKey="Nguye N T">T Nguye n</name>
</author>
<author><name sortKey="Lien, Ps" uniqKey="Lien P">PS Lien</name>
</author>
<author><name sortKey="Le, Qm" uniqKey="Le Q">QM Le</name>
</author>
<author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mounts, A" uniqKey="Mounts A">A Mounts</name>
</author>
<author><name sortKey="Kwong, H" uniqKey="Kwong H">H Kwong</name>
</author>
<author><name sortKey="Izurieta, H" uniqKey="Izurieta H">H Izurieta</name>
</author>
<author><name sortKey="Ho, Yp" uniqKey="Ho Y">YP Ho</name>
</author>
<author><name sortKey="Au, Tp" uniqKey="Au T">TP Au</name>
</author>
<author><name sortKey="Lee, M" uniqKey="Lee M">M Lee</name>
</author>
<author><name sortKey="Buxtonbridges, C" uniqKey="Buxtonbridges C">C BuxtonBridges</name>
</author>
<author><name sortKey="Williams, S" uniqKey="Williams S">S Williams</name>
</author>
<author><name sortKey="Mak, K" uniqKey="Mak K">K Mak</name>
</author>
<author><name sortKey="Katz, J" uniqKey="Katz J">J Katz</name>
</author>
<author><name sortKey="Thompson, W" uniqKey="Thompson W">W Thompson</name>
</author>
<author><name sortKey="Cox, N" uniqKey="Cox N">N Cox</name>
</author>
<author><name sortKey="Fukuda, K" uniqKey="Fukuda K">K Fukuda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yamada, S" uniqKey="Yamada S">S Yamada</name>
</author>
<author><name sortKey="Suzuki, Y" uniqKey="Suzuki Y">Y Suzuki</name>
</author>
<author><name sortKey="Suzuki, T" uniqKey="Suzuki T">T Suzuki</name>
</author>
<author><name sortKey="Le, Mq" uniqKey="Le M">MQ Le</name>
</author>
<author><name sortKey="Nidom, Ca" uniqKey="Nidom C">CA Nidom</name>
</author>
<author><name sortKey="Sakai Tagawa, Y" uniqKey="Sakai Tagawa Y">Y Sakai-Tagawa</name>
</author>
<author><name sortKey="Muramoto, Y" uniqKey="Muramoto Y">Y Muramoto</name>
</author>
<author><name sortKey="Ito, M" uniqKey="Ito M">M Ito</name>
</author>
<author><name sortKey="Kiso, M" uniqKey="Kiso M">M Kiso</name>
</author>
<author><name sortKey="Horimoto, T" uniqKey="Horimoto T">T Horimoto</name>
</author>
<author><name sortKey="Shinya, K" uniqKey="Shinya K">K Shinya</name>
</author>
<author><name sortKey="Sawada, T" uniqKey="Sawada T">T Sawada</name>
</author>
<author><name sortKey="Kiso, M" uniqKey="Kiso M">M Kiso</name>
</author>
<author><name sortKey="Usui, T" uniqKey="Usui T">T Usui</name>
</author>
<author><name sortKey="Murata, T" uniqKey="Murata T">T Murata</name>
</author>
<author><name sortKey="Lin, Y" uniqKey="Lin Y">Y Lin</name>
</author>
<author><name sortKey="Hay, A" uniqKey="Hay A">A Hay</name>
</author>
<author><name sortKey="Haire, Lf" uniqKey="Haire L">LF Haire</name>
</author>
<author><name sortKey="Stevens, Dj" uniqKey="Stevens D">DJ Stevens</name>
</author>
<author><name sortKey="Russell, Rj" uniqKey="Russell R">RJ Russell</name>
</author>
<author><name sortKey="Gamblin, Sj" uniqKey="Gamblin S">SJ Gamblin</name>
</author>
<author><name sortKey="Skehel, Jj" uniqKey="Skehel J">JJ Skehel</name>
</author>
<author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Belshe, Rb" uniqKey="Belshe R">RB Belshe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name>
</author>
<author><name sortKey="Reid, Ah" uniqKey="Reid A">AH Reid</name>
</author>
<author><name sortKey="Lourens, Rm" uniqKey="Lourens R">RM Lourens</name>
</author>
<author><name sortKey="Wang1, R" uniqKey="Wang1 R">R Wang1</name>
</author>
<author><name sortKey="Jin, G" uniqKey="Jin G">G Jin</name>
</author>
<author><name sortKey="Fanning, Tg" uniqKey="Fanning T">TG Fanning</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name>
</author>
<author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Capua, I" uniqKey="Capua I">I Capua</name>
</author>
<author><name sortKey="Alexander, Dj" uniqKey="Alexander D">DJ Alexander</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Finkelstein, Db" uniqKey="Finkelstein D">DB Finkelstein</name>
</author>
<author><name sortKey="Mukatira, S" uniqKey="Mukatira S">S Mukatira</name>
</author>
<author><name sortKey="Mehta, Pk" uniqKey="Mehta P">PK Mehta</name>
</author>
<author><name sortKey="Obenauer, Jc" uniqKey="Obenauer J">JC Obenauer</name>
</author>
<author><name sortKey="Su, X" uniqKey="Su X">X Su</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
<author><name sortKey="Naeve, Cw" uniqKey="Naeve C">CW Naeve</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Gw" uniqKey="Chen G">GW Chen</name>
</author>
<author><name sortKey="Chang, Sc" uniqKey="Chang S">SC Chang</name>
</author>
<author><name sortKey="Mok, Ck" uniqKey="Mok C">CK Mok</name>
</author>
<author><name sortKey="Lo, Yl" uniqKey="Lo Y">YL Lo</name>
</author>
<author><name sortKey="Kung, Yn" uniqKey="Kung Y">YN Kung</name>
</author>
<author><name sortKey="Huang, Jh" uniqKey="Huang J">JH Huang</name>
</author>
<author><name sortKey="Shih, Yh" uniqKey="Shih Y">YH Shih</name>
</author>
<author><name sortKey="Wang, Jy" uniqKey="Wang J">JY Wang</name>
</author>
<author><name sortKey="Chiang, C" uniqKey="Chiang C">C Chiang</name>
</author>
<author><name sortKey="Chen, Cj" uniqKey="Chen C">CJ Chen</name>
</author>
<author><name sortKey="Shih, Sr" uniqKey="Shih S">SR Shih</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scholkpf, B" uniqKey="Scholkpf B">B Schölkpf</name>
</author>
<author><name sortKey="Smola, Aj" uniqKey="Smola A">AJ Smola</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saeys, Y" uniqKey="Saeys Y">Y Saeys</name>
</author>
<author><name sortKey="Inza, I" uniqKey="Inza I">I Inza</name>
</author>
<author><name sortKey="Larranaga, P" uniqKey="Larranaga P">P Larranaga</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Ks" uniqKey="Li K">KS Li</name>
</author>
<author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Smith, Gj" uniqKey="Smith G">GJ Smith</name>
</author>
<author><name sortKey="Xu, Km" uniqKey="Xu K">KM Xu</name>
</author>
<author><name sortKey="Duan, L" uniqKey="Duan L">L Duan</name>
</author>
<author><name sortKey="Rahardjo, Ap" uniqKey="Rahardjo A">AP Rahardjo</name>
</author>
<author><name sortKey="Puthavathana, P" uniqKey="Puthavathana P">P Puthavathana</name>
</author>
<author><name sortKey="Buranathai, C" uniqKey="Buranathai C">C Buranathai</name>
</author>
<author><name sortKey="Nguyen, Td" uniqKey="Nguyen T">TD Nguyen</name>
</author>
<author><name sortKey="Estoepangestie, At" uniqKey="Estoepangestie A">AT Estoepangestie</name>
</author>
<author><name sortKey="Chaisingh, A" uniqKey="Chaisingh A">A Chaisingh</name>
</author>
<author><name sortKey="Auewarakul, P" uniqKey="Auewarakul P">P Auewarakul</name>
</author>
<author><name sortKey="Long, Ht" uniqKey="Long H">HT Long</name>
</author>
<author><name sortKey="Hanh, Nt" uniqKey="Hanh N">NT Hanh</name>
</author>
<author><name sortKey="Webby, Rj" uniqKey="Webby R">RJ Webby</name>
</author>
<author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
<author><name sortKey="Shortridge, Kf" uniqKey="Shortridge K">KF Shortridge</name>
</author>
<author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
<author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tiensin, T" uniqKey="Tiensin T">T Tiensin</name>
</author>
<author><name sortKey="Chaitaweesub, Cp" uniqKey="Chaitaweesub C">CP Chaitaweesub</name>
</author>
<author><name sortKey="Songserm, T" uniqKey="Songserm T">T Songserm</name>
</author>
<author><name sortKey="Chaisingh, A" uniqKey="Chaisingh A">A Chaisingh</name>
</author>
<author><name sortKey="Hoonsuwan, W" uniqKey="Hoonsuwan W">W Hoonsuwan</name>
</author>
<author><name sortKey="Buranathai, C" uniqKey="Buranathai C">C Buranathai</name>
</author>
<author><name sortKey="Parakamawongsa, T" uniqKey="Parakamawongsa T">T Parakamawongsa</name>
</author>
<author><name sortKey="Premashthira, S" uniqKey="Premashthira S">S Premashthira</name>
</author>
<author><name sortKey="Amonsin, A" uniqKey="Amonsin A">A Amonsin</name>
</author>
<author><name sortKey="Gilbert, M" uniqKey="Gilbert M">M Gilbert</name>
</author>
<author><name sortKey="Nielen, M" uniqKey="Nielen M">M Nielen</name>
</author>
<author><name sortKey="Stegeman, A" uniqKey="Stegeman A">A Stegeman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Puthavathana, P" uniqKey="Puthavathana P">P Puthavathana</name>
</author>
<author><name sortKey="Auewarakul, P" uniqKey="Auewarakul P">P Auewarakul</name>
</author>
<author><name sortKey="Charoenying, Pc" uniqKey="Charoenying P">PC Charoenying</name>
</author>
<author><name sortKey="Sangsiriwut, K" uniqKey="Sangsiriwut K">K Sangsiriwut</name>
</author>
<author><name sortKey="Pooruk, P" uniqKey="Pooruk P">P Pooruk</name>
</author>
<author><name sortKey="Boonnak, K" uniqKey="Boonnak K">K Boonnak</name>
</author>
<author><name sortKey="Khanyok, R" uniqKey="Khanyok R">R Khanyok</name>
</author>
<author><name sortKey="Thawachsupa, P" uniqKey="Thawachsupa P">P Thawachsupa</name>
</author>
<author><name sortKey="Kijphati, R" uniqKey="Kijphati R">R Kijphati</name>
</author>
<author><name sortKey="Sawanpanyalert, P" uniqKey="Sawanpanyalert P">P Sawanpanyalert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Salzberg, Sl" uniqKey="Salzberg S">SL Salzberg</name>
</author>
<author><name sortKey="Kingsford, C" uniqKey="Kingsford C">C Kingsford</name>
</author>
<author><name sortKey="Cattoli, G" uniqKey="Cattoli G">G Cattoli</name>
</author>
<author><name sortKey="Spiro, Dj" uniqKey="Spiro D">DJ Spiro</name>
</author>
<author><name sortKey="Janies, Da" uniqKey="Janies D">DA Janies</name>
</author>
<author><name sortKey="Aly, Mm" uniqKey="Aly M">MM Aly</name>
</author>
<author><name sortKey="Brown, Ih" uniqKey="Brown I">IH Brown</name>
</author>
<author><name sortKey="Couacy Hymann, E" uniqKey="Couacy Hymann E">E Couacy-Hymann</name>
</author>
<author><name sortKey="Mia, Gmd" uniqKey="Mia G">GMD Mia</name>
</author>
<author><name sortKey="Dung, Dh" uniqKey="Dung D">DH Dung</name>
</author>
<author><name sortKey="Guercio, A" uniqKey="Guercio A">A Guercio</name>
</author>
<author><name sortKey="Joannis, T" uniqKey="Joannis T">T Joannis</name>
</author>
<author><name sortKey="Ali, Asm" uniqKey="Ali A">ASM Ali</name>
</author>
<author><name sortKey="Osmani, A" uniqKey="Osmani A">A Osmani</name>
</author>
<author><name sortKey="Padalino, I" uniqKey="Padalino I">I Padalino</name>
</author>
<author><name sortKey="Saad, Md" uniqKey="Saad M">MD Saad</name>
</author>
<author><name sortKey="Savi, V" uniqKey="Savi V">V Savi</name>
</author>
<author><name sortKey="Sengamalay, Na" uniqKey="Sengamalay N">NA Sengamalay</name>
</author>
<author><name sortKey="Yingst, S" uniqKey="Yingst S">S Yingst</name>
</author>
<author><name sortKey="Zaborsky, J" uniqKey="Zaborsky J">J Zaborsky</name>
</author>
<author><name sortKey="Zorman Rojs, O" uniqKey="Zorman Rojs O">O Zorman-Rojs</name>
</author>
<author><name sortKey="Ghedin, E" uniqKey="Ghedin E">E Ghedin</name>
</author>
<author><name sortKey="Capua, I" uniqKey="Capua I">I Capua</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lin, Yp" uniqKey="Lin Y">YP Lin</name>
</author>
<author><name sortKey="Shaw, M" uniqKey="Shaw M">M Shaw</name>
</author>
<author><name sortKey="Gregory, V" uniqKey="Gregory V">V Gregory</name>
</author>
<author><name sortKey="Cameron, K" uniqKey="Cameron K">K Cameron</name>
</author>
<author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name>
</author>
<author><name sortKey="Klimov, A" uniqKey="Klimov A">A Klimov</name>
</author>
<author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name>
</author>
<author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name>
</author>
<author><name sortKey="Krauss, S" uniqKey="Krauss S">S Krauss</name>
</author>
<author><name sortKey="Shortridge, K" uniqKey="Shortridge K">K Shortridge</name>
</author>
<author><name sortKey="Webster, R" uniqKey="Webster R">R Webster</name>
</author>
<author><name sortKey="Cox, N" uniqKey="Cox N">N Cox</name>
</author>
<author><name sortKey="Hay, A" uniqKey="Hay A">A Hay</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hoffmann, E" uniqKey="Hoffmann E">E Hoffmann</name>
</author>
<author><name sortKey="Stech, J" uniqKey="Stech J">J Stech</name>
</author>
<author><name sortKey="Leneva, I" uniqKey="Leneva I">I Leneva</name>
</author>
<author><name sortKey="Krauss, S" uniqKey="Krauss S">S Krauss</name>
</author>
<author><name sortKey="Scholtissek, C" uniqKey="Scholtissek C">C Scholtissek</name>
</author>
<author><name sortKey="Chin, Ps" uniqKey="Chin P">PS Chin</name>
</author>
<author><name sortKey="Peiris, M" uniqKey="Peiris M">M Peiris</name>
</author>
<author><name sortKey="Shortridge, Kf" uniqKey="Shortridge K">KF Shortridge</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maines, Tr" uniqKey="Maines T">TR Maines</name>
</author>
<author><name sortKey="Chen, Lm" uniqKey="Chen L">LM Chen</name>
</author>
<author><name sortKey="Matsuoka, Y" uniqKey="Matsuoka Y">Y Matsuoka</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
<author><name sortKey="Rowe, T" uniqKey="Rowe T">T Rowe</name>
</author>
<author><name sortKey="Ortin, J" uniqKey="Ortin J">J Ortin</name>
</author>
<author><name sortKey="Falcon, A" uniqKey="Falcon A">A Falcon</name>
</author>
<author><name sortKey="Hien, Nt" uniqKey="Hien N">NT Hien</name>
</author>
<author><name sortKey="Mai, Lq" uniqKey="Mai L">LQ Mai</name>
</author>
<author><name sortKey="Sedyaningsih, Er" uniqKey="Sedyaningsih E">ER Sedyaningsih</name>
</author>
<author><name sortKey="Harun, S" uniqKey="Harun S">S Harun</name>
</author>
<author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
<author><name sortKey="Donis, Ro" uniqKey="Donis R">RO Donis</name>
</author>
<author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name>
</author>
<author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name>
</author>
<author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Duda, Ro" uniqKey="Duda R">RO Duda</name>
</author>
<author><name sortKey="Hart, Pe" uniqKey="Hart P">PE Hart</name>
</author>
<author><name sortKey="Stork, Dg" uniqKey="Stork D">DG Stork</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guyon, I" uniqKey="Guyon I">I Guyon</name>
</author>
<author><name sortKey="Elisseeff, A" uniqKey="Elisseeff A">A Elisseeff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Edgar, Rc" uniqKey="Edgar R">RC Edgar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brank, J" uniqKey="Brank J">J Brank</name>
</author>
<author><name sortKey="Grobelnik, M" uniqKey="Grobelnik M">M Grobelnik</name>
</author>
<author><name sortKey="Mili Frayling, N" uniqKey="Mili Frayling N">N Milić-Frayling</name>
</author>
<author><name sortKey="Mladeni, D" uniqKey="Mladeni D">D Mladenić</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zavaljevski, N" uniqKey="Zavaljevski N">N Zavaljevski</name>
</author>
<author><name sortKey="Stevens, Fj" uniqKey="Stevens F">FJ Stevens</name>
</author>
<author><name sortKey="Reifman, J" uniqKey="Reifman J">J Reifman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chang, Cc" uniqKey="Chang C">CC Chang</name>
</author>
<author><name sortKey="Lin, Cj" uniqKey="Lin C">CJ Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Olsen, Cw" uniqKey="Olsen C">CW Olsen</name>
</author>
<author><name sortKey="Karasin, Ai" uniqKey="Karasin A">AI Karasin</name>
</author>
<author><name sortKey="Carman, S" uniqKey="Carman S">S Carman</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Bastien, N" uniqKey="Bastien N">N Bastien</name>
</author>
<author><name sortKey="Ojkic, D" uniqKey="Ojkic D">D Ojkic</name>
</author>
<author><name sortKey="Alves, D" uniqKey="Alves D">D Alves</name>
</author>
<author><name sortKey="Charbonneau, G" uniqKey="Charbonneau G">G Charbonneau</name>
</author>
<author><name sortKey="Henning, Bm" uniqKey="Henning B">BM Henning</name>
</author>
<author><name sortKey="Low, De" uniqKey="Low D">DE Low</name>
</author>
<author><name sortKey="Burton, L" uniqKey="Burton L">L Burton</name>
</author>
<author><name sortKey="Broukhanski, G" uniqKey="Broukhanski G">G Broukhanski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bao, Y" uniqKey="Bao Y">Y Bao</name>
</author>
<author><name sortKey="Bolotov, P" uniqKey="Bolotov P">P Bolotov</name>
</author>
<author><name sortKey="Dernovoy, D" uniqKey="Dernovoy D">D Dernovoy</name>
</author>
<author><name sortKey="Kiryutin, B" uniqKey="Kiryutin B">B Kiryutin</name>
</author>
<author><name sortKey="Zaslavsky, L" uniqKey="Zaslavsky L">L Zaslavsky</name>
</author>
<author><name sortKey="Tatusova, T" uniqKey="Tatusova T">T Tatusova</name>
</author>
<author><name sortKey="Ostell, J" uniqKey="Ostell J">J Ostell</name>
</author>
<author><name sortKey="Lipman, D" uniqKey="Lipman D">D Lipman</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
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<tree><country name="États-Unis"><noRegion><name sortKey="Allen, Jonathan E" sort="Allen, Jonathan E" uniqKey="Allen J" first="Jonathan E" last="Allen">Jonathan E. Allen</name>
</noRegion>
<name sortKey="Gardner, Shea N" sort="Gardner, Shea N" uniqKey="Gardner S" first="Shea N" last="Gardner">Shea N. Gardner</name>
<name sortKey="Slezak, Tom R" sort="Slezak, Tom R" uniqKey="Slezak T" first="Tom R" last="Slezak">Tom R. Slezak</name>
<name sortKey="Vitalis, Elizabeth A" sort="Vitalis, Elizabeth A" uniqKey="Vitalis E" first="Elizabeth A" last="Vitalis">Elizabeth A. Vitalis</name>
</country>
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