H2N2V1, Ncbi, Checkpoint, bibRecord, 000296

Prioritization of Influenza Pandemic Vaccination to Minimize Years of Life Lost

Identifieur interne : 000296 ( Ncbi/Checkpoint ); précédent : 000295; suivant : 000297

Prioritization of Influenza Pandemic Vaccination to Minimize Years of Life Lost

Auteurs : Mark A. Miller [États-Unis] ; Cecile Viboud [États-Unis] ; Donald R. Olson [États-Unis] ; Rebecca F. Grais [États-Unis] ; Maia A. Rabaa [États-Unis] ; Lone Simonsen [États-Unis]

Source :

The Journal of infectious diseases [ 0022-1899 ] ; 2008.

RBID : PMC:3206321

Abstract

Background

How to allocate limited vaccine supplies in the event of an influenza pandemic is currently under debate. Conventional vaccination strategies focus on those at highest risk for severe outcomes, including seniors, but do not consider (1) the signature pandemic pattern in which mortality risk is shifted to younger ages, (2) likely reduced vaccine response in seniors, and (3) differences in remaining years of life with age.

Methods

We integrated these factors to project the age-specific years of life lost (YLL) and saved in a future pandemic, on the basis of mortality patterns from 3 historical pandemics, age-specific vaccine efficacy, and the 2000 US population structure.

Results

For a 1918-like scenario, the absolute mortality risk is highest in people <45 years old; in contrast, seniors (those ⩾65 years old) have the highest mortality risk in the 1957 and 1968 scenarios. The greatest YLL savings would be achieved by targeting different age groups in each scenario; people <45 years old in the 1918 scenario, people 45–64 years old in the 1968 scenario, and people >45 years old in the 1957 scenario.

Conclusions

Our findings shift the focus of pandemic vaccination strategies onto younger populations and illustrate the need for real-time surveillance of mortality patterns in a future pandemic. Flexible setting of vaccination priority is essential to minimize mortality.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206321

DOI: 10.1086/589716
PubMed: 18558871
PubMed Central: 3206321

Affiliations:

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PMC:3206321

Le document en format XML

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<p id="P2">We integrated these factors to project the age-specific years of life lost (YLL) and saved in a future pandemic, on the basis of mortality patterns from 3 historical pandemics, age-specific vaccine efficacy, and the 2000 US population structure.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">For a 1918-like scenario, the absolute mortality risk is highest in people <45 years old; in contrast, seniors (those ⩾65 years old) have the highest mortality risk in the 1957 and 1968 scenarios. The greatest YLL savings would be achieved by targeting different age groups in each scenario; people <45 years old in the 1918 scenario, people 45–64 years old in the 1968 scenario, and people >45 years old in the 1957 scenario.</p>
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<sec id="S4"><title>Conclusions</title>
<p id="P4">Our findings shift the focus of pandemic vaccination strategies onto younger populations and illustrate the need for real-time surveillance of mortality patterns in a future pandemic. Flexible setting of vaccination priority is essential to minimize mortality.</p>
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Prioritization of Influenza Pandemic Vaccination to Minimize Years of Life Lost

Prioritization of Influenza Pandemic Vaccination to Minimize Years of Life Lost

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki