Adaptive molecular evolution of virulence genes of avian influenza - A virus subtype H5N1: An analysis of host radiation
Identifieur interne : 000232 ( Ncbi/Checkpoint ); précédent : 000231; suivant : 000233Adaptive molecular evolution of virulence genes of avian influenza - A virus subtype H5N1: An analysis of host radiation
Auteurs : Rocky Kumar ; Partho Halder ; Raju PoddarSource :
- Bioinformation [ 0973-2063 ] ; 2006.
Abstract
The phenomenon of host radiation is strongly influenced by the rates of mutation of their virulence genes. We have studied the molecular evolution of virulence genes (HA, NS, PB2) of the Avian Influenza Virus H5N1 from avian to human hosts. We used a site-specific comparison of synonymous (silent) and non-synonymous (amino acid altering) nucleotide substitutions for the three chosen genes in parasite populations from different hosts. Analyses were made using Maximum Likelihood (ML) genealogies for the null and alternate hypothesis based on differential gamma distribution rates. The null hypothesis had a higher rate of substitution and was found to be more suitable for all the studied genes by Likelihood Ratio Test (LRT). The study showed the NS gene to be having the fastest rate of evolution.
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PubMed: 17597913
PubMed Central: 1891714
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the molecular evolution of virulence genes (HA, NS, PB2) of the Avian Influenza Virus H5N1 from avian to human hosts.
We used a site-specific comparison of synonymous (silent) and non-synonymous (amino acid altering) nucleotide
substitutions for the three chosen genes in parasite populations from different hosts. Analyses were made using Maximum
Likelihood (ML) genealogies for the null and alternate hypothesis based on differential gamma distribution rates. The null
hypothesis had a higher rate of substitution and was found to be more suitable for all the studied genes by Likelihood Ratio
Test (LRT). The study showed the NS gene to be having the fastest rate of evolution.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Halder, Partho" sort="Halder, Partho" uniqKey="Halder P" first="Partho" last="Halder">Partho Halder</name><name sortKey="Kumar, Rocky" sort="Kumar, Rocky" uniqKey="Kumar R" first="Rocky" last="Kumar">Rocky Kumar</name><name sortKey="Poddar, Raju" sort="Poddar, Raju" uniqKey="Poddar R" first="Raju" last="Poddar">Raju Poddar</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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