THE RELATIVE POTENCIES OF ANTI‐INFLUENZA COMPOUNDS
Identifieur interne : 002C46 ( Main/Merge ); précédent : 002C45; suivant : 002C47THE RELATIVE POTENCIES OF ANTI‐INFLUENZA COMPOUNDS
Auteurs : Margaret Tisdale [Royaume-Uni] ; D. J. Bauer [Royaume-Uni]Source :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 1977-05.
Descripteurs français
- KwdFr :
- Adamantane (analogues et dérivés), Adamantane (pharmacologie), Amantadine (pharmacologie), Amines (pharmacologie), Animaux, Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Cellules cultivées, Cycloparaffines (pharmacologie), Infections à Orthomyxoviridae (traitement médicamenteux), Ribavirine (pharmacologie), Souris, Tests de sensibilité microbienne, Virus de la grippe A ().
- MESH :
- analogues et dérivés : Adamantane.
- pharmacologie : Adamantane, Amantadine, Amines, Antiviraux, Cycloparaffines, Ribavirine.
- traitement médicamenteux : Infections à Orthomyxoviridae.
- usage thérapeutique : Antiviraux.
- Animaux, Cellules cultivées, Souris, Tests de sensibilité microbienne, Virus de la grippe A.
English descriptors
- KwdEn :
- Adamantane (analogs & derivatives), Adamantane (pharmacology), Amantadine (pharmacology), Amines (pharmacology), Animals, Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Cells, Cultured, Cycloparaffins (pharmacology), Influenza A virus (drug effects), Mice, Microbial Sensitivity Tests, Orthomyxoviridae Infections (drug therapy), Ribavirin (pharmacology).
- MESH :
- chemical , analogs & derivatives : Adamantane.
- chemical , pharmacology : Adamantane, Amantadine, Amines, Antiviral Agents, Cycloparaffins, Ribavirin.
- chemical , therapeutic use : Antiviral Agents.
- drug effects : Influenza A virus.
- drug therapy : Orthomyxoviridae Infections.
- Animals, Cells, Cultured, Mice, Microbial Sensitivity Tests.
Url:
DOI: 10.1111/j.1749-6632.1977.tb21958.x
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J." last="Bauer">D. J. Bauer</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AC60933597E91FBED3562DB74366744F1F57A6C2</idno><date when="1977" year="1977">1977</date><idno type="doi">10.1111/j.1749-6632.1977.tb21958.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-4HDHZ5SQ-R/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000438</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000438</idno><idno type="wicri:Area/Istex/Curation">000438</idno><idno type="wicri:Area/Istex/Checkpoint">001663</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001663</idno><idno type="wicri:doubleKey">0077-8923:1977:Tisdale M:the:relative:potencies</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">THE RELATIVE POTENCIES OF ANTI‐INFLUENZA COMPOUNDS</title><author><name sortKey="Tisdale, Margaret" sort="Tisdale, Margaret" uniqKey="Tisdale M" first="Margaret" last="Tisdale">Margaret Tisdale</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Wellcome Research Laboratories Beckenham</wicri:cityArea></affiliation></author><author><name sortKey="Bauer, D J" sort="Bauer, D J" uniqKey="Bauer D" first="D. J." last="Bauer">D. J. Bauer</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Wellcome Research Laboratories Beckenham</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Annals of the New York Academy of Sciences</title><title level="j" type="alt">ANNALS OF NEW YORK ACADEMY SCIENCES</title><idno type="ISSN">0077-8923</idno><idno type="eISSN">1749-6632</idno><imprint><biblScope unit="vol">284</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="254">254</biblScope><biblScope unit="page" to="263">263</biblScope><biblScope unit="page-count">10</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1977-05">1977-05</date></imprint><idno type="ISSN">0077-8923</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0077-8923</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The relative potencies of anti-influenza compounds.</title><author><name sortKey="Tisdale, M" sort="Tisdale, M" uniqKey="Tisdale M" first="M" last="Tisdale">M. Tisdale</name></author><author><name sortKey="Bauer, D J" sort="Bauer, D J" uniqKey="Bauer D" first="D J" last="Bauer">D J Bauer</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1977">1977</date><idno type="RBID">pubmed:280137</idno><idno type="pmid">280137</idno><idno type="doi">10.1111/j.1749-6632.1977.tb21958.x</idno><idno type="wicri:Area/PubMed/Corpus">000634</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000634</idno><idno type="wicri:Area/PubMed/Curation">000634</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000634</idno><idno type="wicri:Area/PubMed/Checkpoint">000543</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000543</idno><idno type="wicri:Area/Ncbi/Merge">000D34</idno><idno type="wicri:Area/Ncbi/Curation">000D34</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D34</idno><idno type="wicri:doubleKey">0077-8923:1977:Tisdale M:the:relative:potencies</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The relative potencies of anti-influenza compounds.</title><author><name sortKey="Tisdale, M" sort="Tisdale, M" uniqKey="Tisdale M" first="M" last="Tisdale">M. Tisdale</name></author><author><name sortKey="Bauer, D J" sort="Bauer, D J" uniqKey="Bauer D" first="D J" last="Bauer">D J Bauer</name></author></analytic><series><title level="j">Annals of the New York Academy of Sciences</title><idno type="ISSN">0077-8923</idno><imprint><date when="1977" type="published">1977</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adamantane (analogs & derivatives)</term><term>Adamantane (pharmacology)</term><term>Amantadine (pharmacology)</term><term>Amines (pharmacology)</term><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Antiviral Agents (therapeutic use)</term><term>Cells, Cultured</term><term>Cycloparaffins (pharmacology)</term><term>Influenza A virus (drug effects)</term><term>Mice</term><term>Microbial Sensitivity Tests</term><term>Orthomyxoviridae Infections (drug therapy)</term><term>Ribavirin (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adamantane (analogues et dérivés)</term><term>Adamantane (pharmacologie)</term><term>Amantadine (pharmacologie)</term><term>Amines (pharmacologie)</term><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Antiviraux (usage thérapeutique)</term><term>Cellules cultivées</term><term>Cycloparaffines (pharmacologie)</term><term>Infections à Orthomyxoviridae (traitement médicamenteux)</term><term>Ribavirine (pharmacologie)</term><term>Souris</term><term>Tests de sensibilité microbienne</term><term>Virus de la grippe A ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adamantane</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Adamantane</term><term>Amantadine</term><term>Amines</term><term>Antiviral Agents</term><term>Cycloparaffins</term><term>Ribavirin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Adamantane</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Adamantane</term><term>Amantadine</term><term>Amines</term><term>Antiviraux</term><term>Cycloparaffines</term><term>Ribavirine</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Mice</term><term>Microbial Sensitivity Tests</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Souris</term><term>Tests de sensibilité microbienne</term><term>Virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The relative potencies of some standard anti-influenza compounds have been examined in vitro by plaque reduction in calf kidney cells, and in vivo by reduction in virus titers of the lungs of infected mice. Strains belonging to the four subtypes H0N1, H1N1, H2N2, and H3N2 were employed to compare the activity of amantadine hydrochloride and ribavirin. In vitro for all strains except A/NWS/OO(H0N1) amantadine hydrochloride was 3-4 times more active than ribavirin. In vivo with sensitive strains amantadine hydrochloride produced a plateau effect at higher dose levels, but at lower dose levels was marginally more active than ribavirin. The sensitivity of A/Hong Kong/1/68 (H3N2) to amantadine hydrochloride, rimantadine hydrochloride, cyclooctylamine, and ribavirin was also investigated. In vitro rimantadine hydrochloride was similar in activity to amantadine hydrochloride and ribavirin, but cyclooctylamine was considerably less active. In vivo cyclooctylamine was active only at 150 mg/kg/day, whereas rimantadine hydrochloride produced a plateau effect over a range of concentrations from 9,12-150 mg/kg/day.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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