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Lack of Effect of Oral Ribavirin in Naturally Occurring Influenza A Virus (H1N1) Infection

Identifieur interne : 002954 ( Main/Merge ); précédent : 002953; suivant : 002955

Lack of Effect of Oral Ribavirin in Naturally Occurring Influenza A Virus (H1N1) Infection

Auteurs : Charles B. Smith [États-Unis] ; Richard P. Charette [États-Unis] ; John P. Fox [États-Unis] ; Marion K. Cooney [États-Unis] ; Carrie E. Hall [États-Unis]

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 1980.

RBID : ISTEX:5293B15A4DCB569CF9B1AD1371AB334E09FDF0FA

Abstract

A double-blind placebo-controlled trial of ribavirin was conducted in 97 young adult males naturally infected with influenza virus similar to A/Brazil/I1/78 (H1N1). Ribavirin was given orally at a dose of 1,000 mg/day for five days beginning within 24 or 48 hr after onset of clinical influenza. The clinical signs and symptoms of influenza and quantitative viral shedding were the same in ribavirin- and placebo-treated groups. Ribavirin treatment was associated with significantly fewer fourfold or greater rises in antibody to influenza A viral antigen by the complement-fixation test, while rises in hemagglutination-inhibiting antibody titers occurred with equal frequency in both groups. The ribavirin-treated group experienced significant increases in bilirubin and in reticulocyte counts after onset of therapy.

Url:

https://api.istex.fr/ark:/67375/HXZ-M311FHQK-5/fulltext.pdf

DOI: 10.1093/infdis/141.5.548

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ISTEX:5293B15A4DCB569CF9B1AD1371AB334E09FDF0FA

Le document en format XML

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<author><name sortKey="Charette, Richard P" sort="Charette, Richard P" uniqKey="Charette R" first="Richard P." last="Charette">Richard P. Charette</name>
</author>
<author><name sortKey="Fox, John P" sort="Fox, John P" uniqKey="Fox J" first="John P." last="Fox">John P. Fox</name>
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<author><name sortKey="Cooney, Marion K" sort="Cooney, Marion K" uniqKey="Cooney M" first="Marion K." last="Cooney">Marion K. Cooney</name>
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<author><name sortKey="Hall, Carrie E" sort="Hall, Carrie E" uniqKey="Hall C" first="Carrie E." last="Hall">Carrie E. Hall</name>
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<placeName><region type="state">Utah</region>
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<wicri:cityArea>Department of Medicine, College of Medicine, University of Utah, Salt Lake City</wicri:cityArea>
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<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
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<wicri:cityArea>Department of Pediatrics, College of Medicine, University of Utah, Salt Lake City</wicri:cityArea>
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<placeName><region type="state">Washington (État)</region>
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<wicri:cityArea>School of Public Health and Community Medicine, University of Washington, Seattle</wicri:cityArea>
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<wicri:cityArea>Please address requests for reprints to Dr. Charles B. Smith, Division of Infectious Diseases, Department of Medicine, College of Medicine, University of Utah, Salt Lake City</wicri:cityArea>
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<front><div type="abstract">A double-blind placebo-controlled trial of ribavirin was conducted in 97 young adult males naturally infected with influenza virus similar to A/Brazil/I1/78 (H1N1). Ribavirin was given orally at a dose of 1,000 mg/day for five days beginning within 24 or 48 hr after onset of clinical influenza. The clinical signs and symptoms of influenza and quantitative viral shedding were the same in ribavirin- and placebo-treated groups. Ribavirin treatment was associated with significantly fewer fourfold or greater rises in antibody to influenza A viral antigen by the complement-fixation test, while rises in hemagglutination-inhibiting antibody titers occurred with equal frequency in both groups. The ribavirin-treated group experienced significant increases in bilirubin and in reticulocyte counts after onset of therapy.</div>
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Lack of Effect of Oral Ribavirin in Naturally Occurring Influenza A Virus (H1N1) Infection

Lack of Effect of Oral Ribavirin in Naturally Occurring Influenza A Virus (H1N1) Infection

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Abstract

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