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Antineuraminidase antibody response to vaccination of chickens with intact virus and different submit preparations of the influenza virus strains A/Sing/1/57 (H2N2), A/Hong Kong/1/68 (H3N2) and A/Port Chalmers/1/73 (H3N2).

Identifieur interne : 002930 ( Main/Merge ); précédent : 002929; suivant : 002931

Antineuraminidase antibody response to vaccination of chickens with intact virus and different submit preparations of the influenza virus strains A/Sing/1/57 (H2N2), A/Hong Kong/1/68 (H3N2) and A/Port Chalmers/1/73 (H3N2).

Auteurs : J. Drescher ; U. Desselberger

Source :

RBID : pubmed:6157375

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English descriptors

Abstract

The antineuraminidase (AN) antibody response to vaccination of chickens with intact virus and different subunit preparations of the influenza virus strains A/Sing/1/57 (H2N2), A/Hong Kong/1/68 (H3N2) and A/Pt. Chalmers/1/73 (H3N2) was tested comparatively. Using a photometric method capable of analysing mixtures of AN antibodies against antigenically different N2 neuraminidases, it was concluded that vaccination with subunits produced by treatment with bromelain and Sarkosyl can yield AN antibody response against heterologous neuraminidase. By contrast, vaccination with intact and ether-treated virus gave AN antibody response against homologous neuraminidases. The conclusion was reached that the NA's of the strains A/Sing/1/57 and A/Pt. Chalmers/1/73 share antigenic determinants and that the NA of the strain A/Hong Kong/1/68 shares antigenic determinants with that of the strains A/Sing/1/57 and A/Pt. Chalmers/1/73.

DOI: 10.1007/bf01322703
PubMed: 6157375

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pubmed:6157375

Le document en format XML

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<term>Animals</term>
<term>Antibodies, Viral (biosynthesis)</term>
<term>Bromelains (pharmacology)</term>
<term>Chickens</term>
<term>Epitopes</term>
<term>Ethyl Ethers (pharmacology)</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A Virus, H3N2 Subtype</term>
<term>Influenza A virus (drug effects)</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Neuraminidase (immunology)</term>
<term>Photometry</term>
<term>Surface-Active Agents (pharmacology)</term>
<term>Vaccination</term>
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<term>Animaux</term>
<term>Anticorps antiviraux (biosynthèse)</term>
<term>Bromélaïnes (pharmacologie)</term>
<term>Photométrie</term>
<term>Poulets</term>
<term>Sialidase (immunologie)</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
<term>Tensioactifs (pharmacologie)</term>
<term>Vaccination</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Virus de la grippe A ()</term>
<term>Virus de la grippe A (immunologie)</term>
<term>Épitopes</term>
<term>Éthers éthyliques (pharmacologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en">
<term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en">
<term>Influenza Vaccines</term>
<term>Neuraminidase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en">
<term>Bromelains</term>
<term>Ethyl Ethers</term>
<term>Surface-Active Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr">
<term>Anticorps antiviraux</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en">
<term>Influenza A virus</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr">
<term>Sialidase</term>
<term>Vaccins antigrippaux</term>
<term>Virus de la grippe A</term>
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<term>Influenza A virus</term>
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<term>Tensioactifs</term>
<term>Éthers éthyliques</term>
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<term>Animals</term>
<term>Chickens</term>
<term>Epitopes</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A Virus, H3N2 Subtype</term>
<term>Photometry</term>
<term>Vaccination</term>
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<term>Photométrie</term>
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<term>Sous-type H3N2 du virus de la grippe A</term>
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<term>Virus de la grippe A</term>
<term>Épitopes</term>
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<div type="abstract" xml:lang="en">The antineuraminidase (AN) antibody response to vaccination of chickens with intact virus and different subunit preparations of the influenza virus strains A/Sing/1/57 (H2N2), A/Hong Kong/1/68 (H3N2) and A/Pt. Chalmers/1/73 (H3N2) was tested comparatively. Using a photometric method capable of analysing mixtures of AN antibodies against antigenically different N2 neuraminidases, it was concluded that vaccination with subunits produced by treatment with bromelain and Sarkosyl can yield AN antibody response against heterologous neuraminidase. By contrast, vaccination with intact and ether-treated virus gave AN antibody response against homologous neuraminidases. The conclusion was reached that the NA's of the strains A/Sing/1/57 and A/Pt. Chalmers/1/73 share antigenic determinants and that the NA of the strain A/Hong Kong/1/68 shares antigenic determinants with that of the strains A/Sing/1/57 and A/Pt. Chalmers/1/73.</div>
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