The threat of avian influenza A (H5N1). Part IV: development of vaccines
Identifieur interne : 001436 ( Main/Merge ); précédent : 001435; suivant : 001437The threat of avian influenza A (H5N1). Part IV: development of vaccines
Auteurs : Jindrich Cinatl Jr [Allemagne] ; Martin Michaelis [Allemagne] ; Hans W. Doerr [Allemagne]Source :
- Medical Microbiology and Immunology [ 0300-8584 ] ; 2007-12-01.
Abstract
Abstract: Among emerging and re-emerging infectious diseases, influenza constitutes one of the major threats to mankind. In this review series epidemiologic, virologic and pathologic concerns raised by infections of humans with avian influenza virus A/H5N1 are discussed. This fourth part focuses on vaccine development. Several phase I clinical studies with vaccines against H5 viruses have demonstrated limited efficacy compared to seasonal influenza vaccines. To induce protective immunity two immunisations with increased amounts of H5N1 vaccine were required. Novel vaccination strategies that are egg- and adjuvant-independent, broadly cross-reactive and long-lasting are highly desirable.
Url:
DOI: 10.1007/s00430-007-0052-3
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In this review series epidemiologic, virologic and pathologic concerns raised by infections of humans with avian influenza virus A/H5N1 are discussed. This fourth part focuses on vaccine development. Several phase I clinical studies with vaccines against H5 viruses have demonstrated limited efficacy compared to seasonal influenza vaccines. To induce protective immunity two immunisations with increased amounts of H5N1 vaccine were required. Novel vaccination strategies that are egg- and adjuvant-independent, broadly cross-reactive and long-lasting are highly desirable.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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