Structures of influenza A proteins and insights into antiviral drug targets
Identifieur interne : 000F36 ( Main/Merge ); précédent : 000F35; suivant : 000F37Structures of influenza A proteins and insights into antiviral drug targets
Auteurs : Kalyan Das [États-Unis] ; James M. Aramini [États-Unis] ; Li-Chung Ma [États-Unis] ; Robert M. Krug [États-Unis] ; Eddy Arnold [États-Unis]Source :
- Nature Structural & Molecular Biology [ 1545-9993 ] ; 2010-05.
Abstract
The world is currently undergoing a pandemic caused by an H1N1 influenza A virus, the so-called 'swine flu'. The H5N1 ('bird flu') influenza A viruses, now circulating in Asia, Africa and Europe, are extremely virulent in humans, although they have not so far acquired the ability to transfer efficiently from human to human. These health concerns have spurred considerable interest in understanding the molecular biology of influenza A viruses. Recent structural studies of influenza A virus proteins (or fragments) help enhance our understanding of the molecular mechanisms of the viral proteins and the effects of drug resistance to improve drug design. The structures of domains of the influenza RNA-dependent RNA polymerase and the nonstructural NS1A protein provide opportunities for targeting these proteins to inhibit viral replication.
Url:
- https://api.istex.fr/ark:/67375/GT4-58V65HVT-1/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957899
DOI: 10.1038/nsmb.1779
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Structures of influenza A proteins and insights into antiviral drug targets</title>
<author><name sortKey="Das, Kalyan" sort="Das, Kalyan" uniqKey="Das K" first="Kalyan" last="Das">Kalyan Das</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
<settlement type="city">New Brunswick (New Jersey)</settlement>
</placeName>
<orgName type="university">Université Rutgers</orgName>
</affiliation>
</author>
<author><name sortKey="Aramini, James M" sort="Aramini, James M" uniqKey="Aramini J" first="James M" last="Aramini">James M. Aramini</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A3">Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
<settlement type="city">New Brunswick (New Jersey)</settlement>
</placeName>
<orgName type="university">Université Rutgers</orgName>
</affiliation>
</author>
<author><name sortKey="Ma, Li Chung" sort="Ma, Li Chung" uniqKey="Ma L" first="Li-Chung" last="Ma">Li-Chung Ma</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A3">Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
<settlement type="city">New Brunswick (New Jersey)</settlement>
</placeName>
<orgName type="university">Université Rutgers</orgName>
</affiliation>
</author>
<author><name sortKey="Krug, Robert M" sort="Krug, Robert M" uniqKey="Krug R" first="Robert M" last="Krug">Robert M. Krug</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Institute for Cellular and Molecular Biology, Section of Molecular Genetics and Microbiology, University of Texas, Austin, Texas, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Cellular and Molecular Biology, Section of Molecular Genetics and Microbiology, University of Texas, Austin, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Arnold, Eddy" sort="Arnold, Eddy" uniqKey="Arnold E" first="Eddy" last="Arnold">Eddy Arnold</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
<settlement type="city">New Brunswick (New Jersey)</settlement>
</placeName>
<orgName type="university">Université Rutgers</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature structural & molecular biology</title>
<idno type="ISSN">1545-9993</idno>
<idno type="eISSN">1545-9985</idno>
<imprint><date when="2010">2010</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><p id="P1">The world is currently undergoing a pandemic caused by an H1N1 influenza A virus, the so-called ‘swine flu’. The H5N1 (‘bird flu’) influenza A viruses, now circulating in Asia, Africa and Europe, are extremely virulent in humans, although they have not so far acquired the ability to transfer efficiently from human to human. These health concerns have spurred considerable interest in understanding the molecular biology of influenza A viruses. Recent structural studies of influenza A virus proteins (or fragments) help enhance our understanding of the molecular mechanisms of the viral proteins and the effects of drug resistance to improve drug design. The structures of domains of the influenza RNA-dependent RNA polymerase and the nonstructural NS1A protein provide opportunities for targeting these proteins to inhibit viral replication.</p>
</div>
</front>
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