Is it possible to develop a 'universal' influenza vaccine?
Identifieur interne : 000179 ( Main/Merge ); précédent : 000178; suivant : 000180Is it possible to develop a 'universal' influenza vaccine?
Auteurs : James E. CroweSource :
- Cold Spring Harbor perspectives in biology [ 1943-0264 ] ; 2018.
Abstract
Development of optimal vaccines for influenza is challenging, in part due to the high antigenic variability in field strains associated with genetic shift from reassortment and genetic drift from point mutations. Discovery of conserved antigenic sites on the hemagglutinin (HA) protein for neutralizing antibodies suggested the possibility that influenza vaccines could be developed that induce focused antibody responses to the conserved neutralizing determinants, especially the HA stem region. Recent studies have focused on the antigenicity and immunogenicity of such domains, using monoclonal antibodies and candidate engineered HA stem-based vaccines. Much progress has been made, but we still do not fully understand the biology of the immune response to this unique antigenic region.
Url:
DOI: 10.1101/cshperspect.a029496
PubMed: 28663208
PubMed Central: 5829045
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000827
- to stream Pmc, to step Curation: 000827
- to stream Pmc, to step Checkpoint: 000129
- to stream Ncbi, to step Merge: 000D86
- to stream Ncbi, to step Curation: 000D86
- to stream Ncbi, to step Checkpoint: 000D86
Links to Exploration step
PMC:5829045Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Is it possible to develop a 'universal' influenza vaccine?</title>
<author><name sortKey="Crowe, James E" sort="Crowe, James E" uniqKey="Crowe J" first="James E." last="Crowe">James E. Crowe</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">28663208</idno>
<idno type="pmc">5829045</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829045</idno>
<idno type="RBID">PMC:5829045</idno>
<idno type="doi">10.1101/cshperspect.a029496</idno>
<date when="2018">2018</date>
<idno type="wicri:Area/Pmc/Corpus">000827</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000827</idno>
<idno type="wicri:Area/Pmc/Curation">000827</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000827</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000129</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000129</idno>
<idno type="wicri:Area/Ncbi/Merge">000D86</idno>
<idno type="wicri:Area/Ncbi/Curation">000D86</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000D86</idno>
<idno type="wicri:Area/Main/Merge">000179</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Is it possible to develop a 'universal' influenza vaccine?</title>
<author><name sortKey="Crowe, James E" sort="Crowe, James E" uniqKey="Crowe J" first="James E." last="Crowe">James E. Crowe</name>
</author>
</analytic>
<series><title level="j">Cold Spring Harbor perspectives in biology</title>
<idno type="eISSN">1943-0264</idno>
<imprint><date when="2018">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Development of optimal vaccines for influenza is challenging, in part due to the high antigenic variability in field strains associated with genetic shift from reassortment and genetic drift from point mutations. Discovery of conserved antigenic sites on the hemagglutinin (HA) protein for neutralizing antibodies suggested the possibility that influenza vaccines could be developed that induce focused antibody responses to the conserved neutralizing determinants, especially the HA stem region. Recent studies have focused on the antigenicity and immunogenicity of such domains, using monoclonal antibodies and candidate engineered HA stem-based vaccines. Much progress has been made, but we still do not fully understand the biology of the immune response to this unique antigenic region.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000179 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000179 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Main |étape= Merge |type= RBID |clé= PMC:5829045 |texte= Is it possible to develop a 'universal' influenza vaccine? }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:28663208" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a H2N2V1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |