Childhood immune imprinting to influenza A shapes birth year-specific risk during seasonal H1N1 and H3N2 epidemics
Identifieur interne : 000104 ( Main/Merge ); précédent : 000103; suivant : 000105Childhood immune imprinting to influenza A shapes birth year-specific risk during seasonal H1N1 and H3N2 epidemics
Auteurs : Katelyn M. Gostic [États-Unis] ; Rebecca Bridge [États-Unis] ; Shane Brady [États-Unis] ; Cécile Viboud [États-Unis] ; Michael Worobey [États-Unis] ; James O. Lloyd-Smith [États-Unis]Source :
- PLoS Pathogens [ 1553-7366 ] ; 2019.
Abstract
Across decades of co-circulation in humans, influenza A subtypes H1N1 and H3N2 have caused seasonal epidemics characterized by different age distributions of cases and mortality. H3N2 causes the majority of severe, clinically attended cases in high-risk elderly cohorts, and the majority of overall deaths, whereas H1N1 causes fewer deaths overall, and cases shifted towards young and middle-aged adults. These contrasting age profiles may result from differences in childhood imprinting to H1N1 and H3N2 or from differences in evolutionary rate between subtypes. Here we analyze a large epidemiological surveillance dataset to test whether childhood immune imprinting shapes seasonal influenza epidemiology, and if so, whether it acts primarily via homosubtypic immune memory or via broader, heterosubtypic memory. We also test the impact of evolutionary differences between influenza subtypes on age distributions of cases. Likelihood-based model comparison shows that narrow, within-subtype imprinting shapes seasonal influenza risk alongside age-specific risk factors. The data do not support a strong effect of evolutionary rate, or of broadly protective imprinting that acts across subtypes. Our findings emphasize that childhood exposures can imprint a lifelong immunological bias toward particular influenza subtypes, and that these cohort-specific biases shape epidemic age distributions. As a consequence, newer and less “senior” antibody responses acquired later in life do not provide the same strength of protection as responses imprinted in childhood. Finally, we project that the relatively low mortality burden of H1N1 may increase in the coming decades, as cohorts that lack H1N1-specific imprinting eventually reach old age.
Url:
DOI: 10.1371/journal.ppat.1008109
PubMed: 31856206
PubMed Central: 6922319
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PMC:6922319Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Across decades of co-circulation in humans, influenza A subtypes H1N1 and H3N2 have caused seasonal epidemics characterized by different age distributions of cases and mortality. H3N2 causes the majority of severe, clinically attended cases in high-risk elderly cohorts, and the majority of overall deaths, whereas H1N1 causes fewer deaths overall, and cases shifted towards young and middle-aged adults. These contrasting age profiles may result from differences in childhood imprinting to H1N1 and H3N2 or from differences in evolutionary rate between subtypes. Here we analyze a large epidemiological surveillance dataset to test whether childhood immune imprinting shapes seasonal influenza epidemiology, and if so, whether it acts primarily via homosubtypic immune memory or via broader, heterosubtypic memory. We also test the impact of evolutionary differences between influenza subtypes on age distributions of cases. Likelihood-based model comparison shows that narrow, within-subtype imprinting shapes seasonal influenza risk alongside age-specific risk factors. The data do not support a strong effect of evolutionary rate, or of broadly protective imprinting that acts across subtypes. Our findings emphasize that childhood exposures can imprint a lifelong immunological bias toward particular influenza subtypes, and that these cohort-specific biases shape epidemic age distributions. As a consequence, newer and less “senior” antibody responses acquired later in life do not provide the same strength of protection as responses imprinted in childhood. Finally, we project that the relatively low mortality burden of H1N1 may increase in the coming decades, as cohorts that lack H1N1-specific imprinting eventually reach old age.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Francis, T" uniqKey="Francis T">T. Francis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lessler, J" uniqKey="Lessler J">J Lessler</name>
</author>
<author><name sortKey="Riley, S" uniqKey="Riley S">S Riley</name>
</author>
<author><name sortKey="Read, Jm" uniqKey="Read J">JM Read</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name>
</author>
<author><name sortKey="Zhu, H" uniqKey="Zhu H">H Zhu</name>
</author>
<author><name sortKey="Smith, Gjd" uniqKey="Smith G">GJD Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Henry, C" uniqKey="Henry C">C Henry</name>
</author>
<author><name sortKey="Palm, A Ke" uniqKey="Palm A">A-KE Palm</name>
</author>
<author><name sortKey="Krammer, F" uniqKey="Krammer F">F Krammer</name>
</author>
<author><name sortKey="Wilson, Pc" uniqKey="Wilson P">PC Wilson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, R" uniqKey="Xu R">R Xu</name>
</author>
<author><name sortKey="Ekiert, Dc" uniqKey="Ekiert D">DC Ekiert</name>
</author>
<author><name sortKey="Krause, Jc" uniqKey="Krause J">JC Krause</name>
</author>
<author><name sortKey="Hai, R" uniqKey="Hai R">R Hai</name>
</author>
<author><name sortKey="Crowe, Je" uniqKey="Crowe J">JE Crowe</name>
</author>
<author><name sortKey="Wilson, Ia" uniqKey="Wilson I">IA Wilson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hancock, K" uniqKey="Hancock K">K Hancock</name>
</author>
<author><name sortKey="Veguilla, V" uniqKey="Veguilla V">V Veguilla</name>
</author>
<author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name>
</author>
<author><name sortKey="Zhong, W" uniqKey="Zhong W">W Zhong</name>
</author>
<author><name sortKey="Butler, En" uniqKey="Butler E">EN Butler</name>
</author>
<author><name sortKey="Sun, H" uniqKey="Sun H">H Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Simonsen, L" uniqKey="Simonsen L">L Simonsen</name>
</author>
<author><name sortKey="Spreeuwenberg, P" uniqKey="Spreeuwenberg P">P Spreeuwenberg</name>
</author>
<author><name sortKey="Lustig, R" uniqKey="Lustig R">R Lustig</name>
</author>
<author><name sortKey="Taylor, Rj" uniqKey="Taylor R">RJ Taylor</name>
</author>
<author><name sortKey="Fleming, Dm" uniqKey="Fleming D">DM Fleming</name>
</author>
<author><name sortKey="Kroneman, M" uniqKey="Kroneman M">M Kroneman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Simonsen, L" uniqKey="Simonsen L">L Simonsen</name>
</author>
<author><name sortKey="Reichert, Ta" uniqKey="Reichert T">TA Reichert</name>
</author>
<author><name sortKey="Miller, Ma" uniqKey="Miller M">MA Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ma, J" uniqKey="Ma J">J Ma</name>
</author>
<author><name sortKey="Dushoff, J" uniqKey="Dushoff J">J Dushoff</name>
</author>
<author><name sortKey="Earn, Djd" uniqKey="Earn D">DJD Earn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Worobey, M" uniqKey="Worobey M">M Worobey</name>
</author>
<author><name sortKey="Han, G Z" uniqKey="Han G">G-Z Han</name>
</author>
<author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A Rambaut</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gagnon, A" uniqKey="Gagnon A">A Gagnon</name>
</author>
<author><name sortKey="Miller, Ms" uniqKey="Miller M">MS Miller</name>
</author>
<author><name sortKey="Hallman, Sa" uniqKey="Hallman S">SA Hallman</name>
</author>
<author><name sortKey="Bourbeau, R" uniqKey="Bourbeau R">R Bourbeau</name>
</author>
<author><name sortKey="Herring, Da" uniqKey="Herring D">DA Herring</name>
</author>
<author><name sortKey="Earn, Djd" uniqKey="Earn D">DJD Earn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gostic, Km" uniqKey="Gostic K">KM Gostic</name>
</author>
<author><name sortKey="Ambrose, M" uniqKey="Ambrose M">M Ambrose</name>
</author>
<author><name sortKey="Worobey, M" uniqKey="Worobey M">M Worobey</name>
</author>
<author><name sortKey="Lloyd Smith, Jo" uniqKey="Lloyd Smith J">JO Lloyd-Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khiabanian, H" uniqKey="Khiabanian H">H Khiabanian</name>
</author>
<author><name sortKey="Farrell, Gm" uniqKey="Farrell G">GM Farrell</name>
</author>
<author><name sortKey="George, Ks" uniqKey="George K">KS George</name>
</author>
<author><name sortKey="Rabadan, R" uniqKey="Rabadan R">R Rabadan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Budd, Ap" uniqKey="Budd A">AP Budd</name>
</author>
<author><name sortKey="Beacham, L" uniqKey="Beacham L">L Beacham</name>
</author>
<author><name sortKey="Smith, Cb" uniqKey="Smith C">CB Smith</name>
</author>
<author><name sortKey="Garten, Rj" uniqKey="Garten R">RJ Garten</name>
</author>
<author><name sortKey="Reed, C" uniqKey="Reed C">C Reed</name>
</author>
<author><name sortKey="Kniss, K" uniqKey="Kniss K">K Kniss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lemaitre, M" uniqKey="Lemaitre M">M Lemaitre</name>
</author>
<author><name sortKey="Carrat, F" uniqKey="Carrat F">F Carrat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ng, S" uniqKey="Ng S">S Ng</name>
</author>
<author><name sortKey="Nachbagauer, R" uniqKey="Nachbagauer R">R Nachbagauer</name>
</author>
<author><name sortKey="Balmaseda, A" uniqKey="Balmaseda A">A Balmaseda</name>
</author>
<author><name sortKey="Stadlbauer, D" uniqKey="Stadlbauer D">D Stadlbauer</name>
</author>
<author><name sortKey="Ojeda, S" uniqKey="Ojeda S">S Ojeda</name>
</author>
<author><name sortKey="Patel, M" uniqKey="Patel M">M Patel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arevalo, P" uniqKey="Arevalo P">P Arevalo</name>
</author>
<author><name sortKey="Mclean, Hq" uniqKey="Mclean H">HQ McLean</name>
</author>
<author><name sortKey="Belongia, Ea" uniqKey="Belongia E">EA Belongia</name>
</author>
<author><name sortKey="Cobey, S" uniqKey="Cobey S">S Cobey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gostic, Km" uniqKey="Gostic K">KM Gostic</name>
</author>
<author><name sortKey="Bridge, R" uniqKey="Bridge R">R Bridge</name>
</author>
<author><name sortKey="Brady, S" uniqKey="Brady S">S Brady</name>
</author>
<author><name sortKey="Viboud, C" uniqKey="Viboud C">C Viboud</name>
</author>
<author><name sortKey="Worobey, M" uniqKey="Worobey M">M Worobey</name>
</author>
<author><name sortKey="Lloyd Smith, Jo" uniqKey="Lloyd Smith J">JO Lloyd-Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, Qs" uniqKey="Huang Q">QS Huang</name>
</author>
<author><name sortKey="Bandaranayake, D" uniqKey="Bandaranayake D">D Bandaranayake</name>
</author>
<author><name sortKey="Wood, T" uniqKey="Wood T">T Wood</name>
</author>
<author><name sortKey="Newbern, Ec" uniqKey="Newbern E">EC Newbern</name>
</author>
<author><name sortKey="Seeds, R" uniqKey="Seeds R">R Seeds</name>
</author>
<author><name sortKey="Ralston, J" uniqKey="Ralston J">J Ralston</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cowling, Bj" uniqKey="Cowling B">BJ Cowling</name>
</author>
<author><name sortKey="Sullivan, Sg" uniqKey="Sullivan S">SG Sullivan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Memoli, Mj" uniqKey="Memoli M">MJ Memoli</name>
</author>
<author><name sortKey="Shaw, Pa" uniqKey="Shaw P">PA Shaw</name>
</author>
<author><name sortKey="Han, A" uniqKey="Han A">A Han</name>
</author>
<author><name sortKey="Czajkowski, L" uniqKey="Czajkowski L">L Czajkowski</name>
</author>
<author><name sortKey="Reed, S" uniqKey="Reed S">S Reed</name>
</author>
<author><name sortKey="Athota, R" uniqKey="Athota R">R Athota</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wrammert, J" uniqKey="Wrammert J">J Wrammert</name>
</author>
<author><name sortKey="Koutsonanos, D" uniqKey="Koutsonanos D">D Koutsonanos</name>
</author>
<author><name sortKey="Li, G M" uniqKey="Li G">G-M Li</name>
</author>
<author><name sortKey="Edupuganti, S" uniqKey="Edupuganti S">S Edupuganti</name>
</author>
<author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name>
</author>
<author><name sortKey="Morrissey, M" uniqKey="Morrissey M">M Morrissey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pica, N" uniqKey="Pica N">N Pica</name>
</author>
<author><name sortKey="Hai, R" uniqKey="Hai R">R Hai</name>
</author>
<author><name sortKey="Krammer, F" uniqKey="Krammer F">F Krammer</name>
</author>
<author><name sortKey="Wang, Tt" uniqKey="Wang T">TT Wang</name>
</author>
<author><name sortKey="Maamary, J" uniqKey="Maamary J">J Maamary</name>
</author>
<author><name sortKey="Eggink, D" uniqKey="Eggink D">D Eggink</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krammer, F" uniqKey="Krammer F">F. Krammer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andrews, Sf" uniqKey="Andrews S">SF Andrews</name>
</author>
<author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name>
</author>
<author><name sortKey="Kaur, K" uniqKey="Kaur K">K Kaur</name>
</author>
<author><name sortKey="Popova, Li" uniqKey="Popova L">LI Popova</name>
</author>
<author><name sortKey="Ho, Iy" uniqKey="Ho I">IY Ho</name>
</author>
<author><name sortKey="Pauli, Nt" uniqKey="Pauli N">NT Pauli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zost, Sj" uniqKey="Zost S">SJ Zost</name>
</author>
<author><name sortKey="Wu, Nc" uniqKey="Wu N">NC Wu</name>
</author>
<author><name sortKey="Hensley, Se" uniqKey="Hensley S">SE Hensley</name>
</author>
<author><name sortKey="Wilson, Ia" uniqKey="Wilson I">IA Wilson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grenfell, Bt" uniqKey="Grenfell B">BT Grenfell</name>
</author>
<author><name sortKey="Pybus, Og" uniqKey="Pybus O">OG Pybus</name>
</author>
<author><name sortKey="Gog, Jr" uniqKey="Gog J">JR Gog</name>
</author>
<author><name sortKey="Wood, Jln" uniqKey="Wood J">JLN Wood</name>
</author>
<author><name sortKey="Daly, Jm" uniqKey="Daly J">JM Daly</name>
</author>
<author><name sortKey="Mumford, Ja" uniqKey="Mumford J">JA Mumford</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Henry, C" uniqKey="Henry C">C Henry</name>
</author>
<author><name sortKey="Zheng, N Y" uniqKey="Zheng N">N-Y Zheng</name>
</author>
<author><name sortKey="Huang, M" uniqKey="Huang M">M Huang</name>
</author>
<author><name sortKey="Cabanov, A" uniqKey="Cabanov A">A Cabanov</name>
</author>
<author><name sortKey="Rojas, Kt" uniqKey="Rojas K">KT Rojas</name>
</author>
<author><name sortKey="Kaur, K" uniqKey="Kaur K">K Kaur</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ranjeva, S" uniqKey="Ranjeva S">S Ranjeva</name>
</author>
<author><name sortKey="Subramanian, R" uniqKey="Subramanian R">R Subramanian</name>
</author>
<author><name sortKey="Fang, Vj" uniqKey="Fang V">VJ Fang</name>
</author>
<author><name sortKey="Leung, Gm" uniqKey="Leung G">GM Leung</name>
</author>
<author><name sortKey="Ip, Dkm" uniqKey="Ip D">DKM Ip</name>
</author>
<author><name sortKey="Perera, Rapm" uniqKey="Perera R">RAPM Perera</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miller, Ms" uniqKey="Miller M">MS Miller</name>
</author>
<author><name sortKey="Gardner, Tj" uniqKey="Gardner T">TJ Gardner</name>
</author>
<author><name sortKey="Krammer, F" uniqKey="Krammer F">F Krammer</name>
</author>
<author><name sortKey="Aguado, Lc" uniqKey="Aguado L">LC Aguado</name>
</author>
<author><name sortKey="Tortorella, D" uniqKey="Tortorella D">D Tortorella</name>
</author>
<author><name sortKey="Basler, Cf" uniqKey="Basler C">CF Basler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tesini, Bl" uniqKey="Tesini B">BL Tesini</name>
</author>
<author><name sortKey="Kanagaiah, P" uniqKey="Kanagaiah P">P Kanagaiah</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Hahn, M" uniqKey="Hahn M">M Hahn</name>
</author>
<author><name sortKey="Halliley, Jl" uniqKey="Halliley J">JL Halliley</name>
</author>
<author><name sortKey="Chaves, Fa" uniqKey="Chaves F">FA Chaves</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thompson, Ww" uniqKey="Thompson W">WW Thompson</name>
</author>
<author><name sortKey="Shay, Dk" uniqKey="Shay D">DK Shay</name>
</author>
<author><name sortKey="Weintraub, E" uniqKey="Weintraub E">E Weintraub</name>
</author>
<author><name sortKey="Brammer, L" uniqKey="Brammer L">L Brammer</name>
</author>
<author><name sortKey="Cox, N" uniqKey="Cox N">N Cox</name>
</author>
<author><name sortKey="Anderson, Lj" uniqKey="Anderson L">LJ Anderson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bedford, T" uniqKey="Bedford T">T Bedford</name>
</author>
<author><name sortKey="Riley, S" uniqKey="Riley S">S Riley</name>
</author>
<author><name sortKey="Barr, Ig" uniqKey="Barr I">IG Barr</name>
</author>
<author><name sortKey="Broor, S" uniqKey="Broor S">S Broor</name>
</author>
<author><name sortKey="Chadha, M" uniqKey="Chadha M">M Chadha</name>
</author>
<author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Erbelding, Ej" uniqKey="Erbelding E">EJ Erbelding</name>
</author>
<author><name sortKey="Post, Dj" uniqKey="Post D">DJ Post</name>
</author>
<author><name sortKey="Stemmy, Ej" uniqKey="Stemmy E">EJ Stemmy</name>
</author>
<author><name sortKey="Roberts, Pc" uniqKey="Roberts P">PC Roberts</name>
</author>
<author><name sortKey="Augustine, Ad" uniqKey="Augustine A">AD Augustine</name>
</author>
<author><name sortKey="Ferguson, S" uniqKey="Ferguson S">S Ferguson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bolker, Bm" uniqKey="Bolker B">BM Bolker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burnham, Kp" uniqKey="Burnham K">KP Burnham</name>
</author>
<author><name sortKey="Anderson, Dr" uniqKey="Anderson D">DR Anderson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hadfield, J" uniqKey="Hadfield J">J Hadfield</name>
</author>
<author><name sortKey="Megill, C" uniqKey="Megill C">C Megill</name>
</author>
<author><name sortKey="Bell, Sm" uniqKey="Bell S">SM Bell</name>
</author>
<author><name sortKey="Huddleston, J" uniqKey="Huddleston J">J Huddleston</name>
</author>
<author><name sortKey="Potter, B" uniqKey="Potter B">B Potter</name>
</author>
<author><name sortKey="Callender, C" uniqKey="Callender C">C Callender</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Neher, Ra" uniqKey="Neher R">RA Neher</name>
</author>
<author><name sortKey="Bedford, T" uniqKey="Bedford T">T Bedford</name>
</author>
<author><name sortKey="Daniels, Rs" uniqKey="Daniels R">RS Daniels</name>
</author>
<author><name sortKey="Russell, Ca" uniqKey="Russell C">CA Russell</name>
</author>
<author><name sortKey="Shraiman, Bi" uniqKey="Shraiman B">BI Shraiman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bedford, T" uniqKey="Bedford T">T Bedford</name>
</author>
<author><name sortKey="Suchard, Ma" uniqKey="Suchard M">MA Suchard</name>
</author>
<author><name sortKey="Lemey, P" uniqKey="Lemey P">P Lemey</name>
</author>
<author><name sortKey="Dudas, G" uniqKey="Dudas G">G Dudas</name>
</author>
<author><name sortKey="Gregory, V" uniqKey="Gregory V">V Gregory</name>
</author>
<author><name sortKey="Hay, Aj" uniqKey="Hay A">AJ Hay</name>
</author>
<author><name sortKey="Losick, R" uniqKey="Losick R">R Losick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, Dj" uniqKey="Smith D">DJ Smith</name>
</author>
<author><name sortKey="Lapedes, As" uniqKey="Lapedes A">AS Lapedes</name>
</author>
<author><name sortKey="Jong, Jc De" uniqKey="Jong J">JC de Jong</name>
</author>
<author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name>
</author>
<author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name>
</author>
<author><name sortKey="Osterhaus, Adme" uniqKey="Osterhaus A">ADME Osterhaus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cobey, S" uniqKey="Cobey S">S Cobey</name>
</author>
<author><name sortKey="Hensley, Se" uniqKey="Hensley S">SE Hensley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Linderman, Sl" uniqKey="Linderman S">SL Linderman</name>
</author>
<author><name sortKey="Chambers, Bs" uniqKey="Chambers B">BS Chambers</name>
</author>
<author><name sortKey="Zost, Sj" uniqKey="Zost S">SJ Zost</name>
</author>
<author><name sortKey="Parkhouse, K" uniqKey="Parkhouse K">K Parkhouse</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Herrmann, C" uniqKey="Herrmann C">C Herrmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Y Q" uniqKey="Chen Y">Y-Q Chen</name>
</author>
<author><name sortKey="Wohlbold, Tj" uniqKey="Wohlbold T">TJ Wohlbold</name>
</author>
<author><name sortKey="Zheng, N Y" uniqKey="Zheng N">N-Y Zheng</name>
</author>
<author><name sortKey="Huang, M" uniqKey="Huang M">M Huang</name>
</author>
<author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name>
</author>
<author><name sortKey="Neu, Ke" uniqKey="Neu K">KE Neu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andrews, Sf" uniqKey="Andrews S">SF Andrews</name>
</author>
<author><name sortKey="Chambers, Mj" uniqKey="Chambers M">MJ Chambers</name>
</author>
<author><name sortKey="Schramm, Ca" uniqKey="Schramm C">CA Schramm</name>
</author>
<author><name sortKey="Plyler, J" uniqKey="Plyler J">J Plyler</name>
</author>
<author><name sortKey="Raab, Je" uniqKey="Raab J">JE Raab</name>
</author>
<author><name sortKey="Kanekiyo, M" uniqKey="Kanekiyo M">M Kanekiyo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matsuda, K" uniqKey="Matsuda K">K Matsuda</name>
</author>
<author><name sortKey="Huang, J" uniqKey="Huang J">J Huang</name>
</author>
<author><name sortKey="Zhou, T" uniqKey="Zhou T">T Zhou</name>
</author>
<author><name sortKey="Sheng, Z" uniqKey="Sheng Z">Z Sheng</name>
</author>
<author><name sortKey="Kang, Bh" uniqKey="Kang B">BH Kang</name>
</author>
<author><name sortKey="Ishida, E" uniqKey="Ishida E">E Ishida</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ramiscal, Rr" uniqKey="Ramiscal R">RR Ramiscal</name>
</author>
<author><name sortKey="Vinuesa, Cg" uniqKey="Vinuesa C">CG Vinuesa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rozo, M" uniqKey="Rozo M">M Rozo</name>
</author>
<author><name sortKey="Gronvall, Gk" uniqKey="Gronvall G">GK Gronvall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dushoff, J" uniqKey="Dushoff J">J Dushoff</name>
</author>
<author><name sortKey="Plotkin, Jb" uniqKey="Plotkin J">JB Plotkin</name>
</author>
<author><name sortKey="Viboud, C" uniqKey="Viboud C">C Viboud</name>
</author>
<author><name sortKey="Earn, Djd" uniqKey="Earn D">DJD Earn</name>
</author>
<author><name sortKey="Simonsen, L" uniqKey="Simonsen L">L Simonsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lewnard, Ja" uniqKey="Lewnard J">JA Lewnard</name>
</author>
<author><name sortKey="Cobey, S" uniqKey="Cobey S">S Cobey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gagnon, A" uniqKey="Gagnon A">A Gagnon</name>
</author>
<author><name sortKey="Acosta, E" uniqKey="Acosta E">E Acosta</name>
</author>
<author><name sortKey="Miller, Ms" uniqKey="Miller M">MS Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Klein, Sl" uniqKey="Klein S">SL Klein</name>
</author>
<author><name sortKey="Flanagan, Kl" uniqKey="Flanagan K">KL Flanagan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vom Steeg, Lg" uniqKey="Vom Steeg L">LG vom Steeg</name>
</author>
<author><name sortKey="Klein, Sl" uniqKey="Klein S">SL Klein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Glezen, Wp" uniqKey="Glezen W">WP Glezen</name>
</author>
<author><name sortKey="Keitel, Wa" uniqKey="Keitel W">WA Keitel</name>
</author>
<author><name sortKey="Taber, Lh" uniqKey="Taber L">LH Taber</name>
</author>
<author><name sortKey="Piedra, Pa" uniqKey="Piedra P">PA Piedra</name>
</author>
<author><name sortKey="Clover, Rd" uniqKey="Clover R">RD Clover</name>
</author>
<author><name sortKey="Couch, Rb" uniqKey="Couch R">RB Couch</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Sagulenko, P" uniqKey="Sagulenko P">P Sagulenko</name>
</author>
<author><name sortKey="Puller, V" uniqKey="Puller V">V Puller</name>
</author>
<author><name sortKey="Neher, Ra" uniqKey="Neher R">RA Neher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bogner, P" uniqKey="Bogner P">P Bogner</name>
</author>
<author><name sortKey="Capua, I" uniqKey="Capua I">I Capua</name>
</author>
<author><name sortKey="Lipman, Dj" uniqKey="Lipman D">DJ Lipman</name>
</author>
<author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name>
</author>
</analytic>
</biblStruct>
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