Efficient Inhibition of Avian and Seasonal Influenza A Viruses by a Virus-Specific Dicer-Substrate Small Interfering RNA Swarm in Human Monocyte-Derived Macrophages and Dendritic Cells
Identifieur interne : 000093 ( Main/Merge ); précédent : 000092; suivant : 000094Efficient Inhibition of Avian and Seasonal Influenza A Viruses by a Virus-Specific Dicer-Substrate Small Interfering RNA Swarm in Human Monocyte-Derived Macrophages and Dendritic Cells
Auteurs : Miao Jiang [Finlande] ; Pamela Österlund [Finlande] ; Veera Westenius [Finlande] ; Deyin Guo [République populaire de Chine] ; Minna M. Poranen [Finlande] ; Dennis H. Bamford [Finlande] ; Ilkka Julkunen [Finlande]Source :
- Journal of Virology [ 0022-538X ] ; 2019.
Abstract
In spite of the enormous amount of research, influenza virus is still one of the major challenges for medical virology due to its capacity to generate new variants, which potentially lead to severe epidemics and pandemics. We demonstrated here that a swarm of small interfering RNA (siRNA) molecules, including more than 100 different antiviral RNA molecules targeting the most conserved regions of the influenza A virus genome, could efficiently inhibit the replication of all tested avian and seasonal influenza A variants in human primary monocyte-derived macrophages and dendritic cells. The wide antiviral spectrum makes the virus-specific siRNA swarm a potentially efficient treatment modality against both avian and seasonal influenza viruses.
Url:
DOI: 10.1128/JVI.01916-18
PubMed: 30463970
PubMed Central: 6364019
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PMC:6364019Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>In spite of the enormous amount of research, influenza virus is still one of the major challenges for medical virology due to its capacity to generate new variants, which potentially lead to severe epidemics and pandemics. We demonstrated here that a swarm of small interfering RNA (siRNA) molecules, including more than 100 different antiviral RNA molecules targeting the most conserved regions of the influenza A virus genome, could efficiently inhibit the replication of all tested avian and seasonal influenza A variants in human primary monocyte-derived macrophages and dendritic cells. The wide antiviral spectrum makes the virus-specific siRNA swarm a potentially efficient treatment modality against both avian and seasonal influenza viruses.</p>
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