The PB2 Subunit of the Influenza Virus RNA Polymerase Affects Virulence by Interacting with the Mitochondrial Antiviral Signaling Protein and Inhibiting Expression of Beta Interferon▿
Identifieur interne : 000E09 ( Main/Exploration ); précédent : 000E08; suivant : 000E10The PB2 Subunit of the Influenza Virus RNA Polymerase Affects Virulence by Interacting with the Mitochondrial Antiviral Signaling Protein and Inhibiting Expression of Beta Interferon▿
Auteurs : Katy M. Graef ; Frank T. Vreede ; Yuk-Fai Lau ; Amber W. Mccall ; Simon M. Carr ; Kanta Subbarao ; Ervin FodorSource :
- Journal of Virology [ 0022-538X ] ; 2010.
Descripteurs français
- KwdFr :
- Alignement de séquences, Animaux, Données de séquences moléculaires, Femelle, Grippe humaine (génétique), Grippe humaine (métabolisme), Grippe humaine (virologie), Humains, Interactions hôte-pathogène, Interféron bêta (génétique), Interféron bêta (métabolisme), Liaison aux protéines, Protéines adaptatrices de la transduction du signal (génétique), Protéines adaptatrices de la transduction du signal (métabolisme), Protéines virales (), Protéines virales (génétique), Protéines virales (métabolisme), RNA replicase (), RNA replicase (génétique), RNA replicase (métabolisme), Régulation négative, Souris, Souris de lignée C57BL, Sous-type H1N1 du virus de la grippe A (enzymologie), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (pathogénicité), Sous-type H2N2 du virus de la grippe A (enzymologie), Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (pathogénicité), Sous-type H5N1 du virus de la grippe A (enzymologie), Sous-type H5N1 du virus de la grippe A (génétique), Sous-type H5N1 du virus de la grippe A (pathogénicité), Séquence d'acides aminés, Virulence, Virus de la grippe A (enzymologie), Virus de la grippe A (génétique), Virus de la grippe A (pathogénicité).
- MESH :
- enzymologie : Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Virus de la grippe A.
- génétique : Grippe humaine, Interféron bêta, Protéines adaptatrices de la transduction du signal, Protéines virales, RNA replicase, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Virus de la grippe A.
- métabolisme : Grippe humaine, Interféron bêta, Protéines adaptatrices de la transduction du signal, Protéines virales, RNA replicase.
- pathogénicité : Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Virus de la grippe A.
- virologie : Grippe humaine.
- Alignement de séquences, Animaux, Données de séquences moléculaires, Femelle, Humains, Interactions hôte-pathogène, Liaison aux protéines, Protéines virales, RNA replicase, Régulation négative, Souris, Souris de lignée C57BL, Séquence d'acides aminés, Virulence.
English descriptors
- KwdEn :
- Adaptor Proteins, Signal Transducing (genetics), Adaptor Proteins, Signal Transducing (metabolism), Amino Acid Sequence, Animals, Down-Regulation, Female, Host-Pathogen Interactions, Humans, Influenza A Virus, H1N1 Subtype (enzymology), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (pathogenicity), Influenza A Virus, H2N2 Subtype (enzymology), Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (pathogenicity), Influenza A Virus, H5N1 Subtype (enzymology), Influenza A Virus, H5N1 Subtype (genetics), Influenza A Virus, H5N1 Subtype (pathogenicity), Influenza A virus (enzymology), Influenza A virus (genetics), Influenza A virus (pathogenicity), Influenza, Human (genetics), Influenza, Human (metabolism), Influenza, Human (virology), Interferon-beta (genetics), Interferon-beta (metabolism), Mice, Mice, Inbred C57BL, Molecular Sequence Data, Protein Binding, RNA Replicase (chemistry), RNA Replicase (genetics), RNA Replicase (metabolism), Sequence Alignment, Viral Proteins (chemistry), Viral Proteins (genetics), Viral Proteins (metabolism), Virulence.
- MESH :
- chemical , chemistry : RNA Replicase, Viral Proteins.
- chemical , genetics : Adaptor Proteins, Signal Transducing, Interferon-beta, RNA Replicase, Viral Proteins.
- chemical , metabolism : Adaptor Proteins, Signal Transducing, Interferon-beta, RNA Replicase, Viral Proteins.
- enzymology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H5N1 Subtype, Influenza A virus.
- genetics : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H5N1 Subtype, Influenza A virus, Influenza, Human.
- metabolism : Influenza, Human.
- pathogenicity : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H5N1 Subtype, Influenza A virus.
- virology : Influenza, Human.
- Amino Acid Sequence, Animals, Down-Regulation, Female, Host-Pathogen Interactions, Humans, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Protein Binding, Sequence Alignment, Virulence.
Abstract
The PB2 subunit of the influenza virus RNA polymerase is a major virulence determinant of influenza viruses. However, the molecular mechanisms involved remain unknown. It was previously shown that the PB2 protein, in addition to its nuclear localization, also accumulates in the mitochondria. Here, we demonstrate that the PB2 protein interacts with the mitochondrial antiviral signaling protein, MAVS (also known as IPS-1, VISA, or Cardif), and inhibits MAVS-mediated beta interferon (IFN-β) expression. In addition, we show that PB2 proteins of influenza viruses differ in their abilities to associate with the mitochondria. In particular, the PB2 proteins of seasonal human influenza viruses localize to the mitochondria while PB2 proteins of avian influenza viruses are nonmitochondrial. This difference in localization is caused by a single amino acid polymorphism in the PB2 mitochondrial targeting signal. In order to address the functional significance of the mitochondrial localization of the PB2 protein
Url:
DOI: 10.1128/JVI.00879-10
PubMed: 20538852
PubMed Central: 2919034
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000720
- to stream Pmc, to step Curation: 000720
- to stream Pmc, to step Checkpoint: 000876
- to stream PubMed, to step Corpus: 000196
- to stream PubMed, to step Curation: 000196
- to stream PubMed, to step Checkpoint: 000173
- to stream Ncbi, to step Merge: 000538
- to stream Ncbi, to step Curation: 000538
- to stream Ncbi, to step Checkpoint: 000538
- to stream Main, to step Merge: 000E15
- to stream Main, to step Curation: 000E09
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The PB2 Subunit of the Influenza Virus RNA Polymerase Affects Virulence by Interacting with the Mitochondrial Antiviral Signaling Protein and Inhibiting Expression of Beta Interferon<xref ref-type="fn" rid="fn3">▿</xref>
</title>
<author><name sortKey="Graef, Katy M" sort="Graef, Katy M" uniqKey="Graef K" first="Katy M." last="Graef">Katy M. Graef</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vreede, Frank T" sort="Vreede, Frank T" uniqKey="Vreede F" first="Frank T." last="Vreede">Frank T. Vreede</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lau, Yuk Fai" sort="Lau, Yuk Fai" uniqKey="Lau Y" first="Yuk-Fai" last="Lau">Yuk-Fai Lau</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mccall, Amber W" sort="Mccall, Amber W" uniqKey="Mccall A" first="Amber W." last="Mccall">Amber W. Mccall</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Carr, Simon M" sort="Carr, Simon M" uniqKey="Carr S" first="Simon M." last="Carr">Simon M. Carr</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fodor, Ervin" sort="Fodor, Ervin" uniqKey="Fodor E" first="Ervin" last="Fodor">Ervin Fodor</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20538852</idno>
<idno type="pmc">2919034</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919034</idno>
<idno type="RBID">PMC:2919034</idno>
<idno type="doi">10.1128/JVI.00879-10</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">000720</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000720</idno>
<idno type="wicri:Area/Pmc/Curation">000720</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000720</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000876</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000876</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:20538852</idno>
<idno type="wicri:Area/PubMed/Corpus">000196</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000196</idno>
<idno type="wicri:Area/PubMed/Curation">000196</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000196</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000173</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000173</idno>
<idno type="wicri:Area/Ncbi/Merge">000538</idno>
<idno type="wicri:Area/Ncbi/Curation">000538</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000538</idno>
<idno type="wicri:doubleKey">0022-538X:2010:Graef K:the:pb:subunit</idno>
<idno type="wicri:Area/Main/Merge">000E15</idno>
<idno type="wicri:Area/Main/Curation">000E09</idno>
<idno type="wicri:Area/Main/Exploration">000E09</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The PB2 Subunit of the Influenza Virus RNA Polymerase Affects Virulence by Interacting with the Mitochondrial Antiviral Signaling Protein and Inhibiting Expression of Beta Interferon<xref ref-type="fn" rid="fn3">▿</xref>
</title>
<author><name sortKey="Graef, Katy M" sort="Graef, Katy M" uniqKey="Graef K" first="Katy M." last="Graef">Katy M. Graef</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vreede, Frank T" sort="Vreede, Frank T" uniqKey="Vreede F" first="Frank T." last="Vreede">Frank T. Vreede</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lau, Yuk Fai" sort="Lau, Yuk Fai" uniqKey="Lau Y" first="Yuk-Fai" last="Lau">Yuk-Fai Lau</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mccall, Amber W" sort="Mccall, Amber W" uniqKey="Mccall A" first="Amber W." last="Mccall">Amber W. Mccall</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Carr, Simon M" sort="Carr, Simon M" uniqKey="Carr S" first="Simon M." last="Carr">Simon M. Carr</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fodor, Ervin" sort="Fodor, Ervin" uniqKey="Fodor E" first="Ervin" last="Fodor">Ervin Fodor</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptor Proteins, Signal Transducing (genetics)</term>
<term>Adaptor Proteins, Signal Transducing (metabolism)</term>
<term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Down-Regulation</term>
<term>Female</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype (enzymology)</term>
<term>Influenza A Virus, H1N1 Subtype (genetics)</term>
<term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term>
<term>Influenza A Virus, H2N2 Subtype (enzymology)</term>
<term>Influenza A Virus, H2N2 Subtype (genetics)</term>
<term>Influenza A Virus, H2N2 Subtype (pathogenicity)</term>
<term>Influenza A Virus, H5N1 Subtype (enzymology)</term>
<term>Influenza A Virus, H5N1 Subtype (genetics)</term>
<term>Influenza A Virus, H5N1 Subtype (pathogenicity)</term>
<term>Influenza A virus (enzymology)</term>
<term>Influenza A virus (genetics)</term>
<term>Influenza A virus (pathogenicity)</term>
<term>Influenza, Human (genetics)</term>
<term>Influenza, Human (metabolism)</term>
<term>Influenza, Human (virology)</term>
<term>Interferon-beta (genetics)</term>
<term>Interferon-beta (metabolism)</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Molecular Sequence Data</term>
<term>Protein Binding</term>
<term>RNA Replicase (chemistry)</term>
<term>RNA Replicase (genetics)</term>
<term>RNA Replicase (metabolism)</term>
<term>Sequence Alignment</term>
<term>Viral Proteins (chemistry)</term>
<term>Viral Proteins (genetics)</term>
<term>Viral Proteins (metabolism)</term>
<term>Virulence</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term>
<term>Animaux</term>
<term>Données de séquences moléculaires</term>
<term>Femelle</term>
<term>Grippe humaine (génétique)</term>
<term>Grippe humaine (métabolisme)</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Interactions hôte-pathogène</term>
<term>Interféron bêta (génétique)</term>
<term>Interféron bêta (métabolisme)</term>
<term>Liaison aux protéines</term>
<term>Protéines adaptatrices de la transduction du signal (génétique)</term>
<term>Protéines adaptatrices de la transduction du signal (métabolisme)</term>
<term>Protéines virales ()</term>
<term>Protéines virales (génétique)</term>
<term>Protéines virales (métabolisme)</term>
<term>RNA replicase ()</term>
<term>RNA replicase (génétique)</term>
<term>RNA replicase (métabolisme)</term>
<term>Régulation négative</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Sous-type H1N1 du virus de la grippe A (enzymologie)</term>
<term>Sous-type H1N1 du virus de la grippe A (génétique)</term>
<term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term>
<term>Sous-type H2N2 du virus de la grippe A (enzymologie)</term>
<term>Sous-type H2N2 du virus de la grippe A (génétique)</term>
<term>Sous-type H2N2 du virus de la grippe A (pathogénicité)</term>
<term>Sous-type H5N1 du virus de la grippe A (enzymologie)</term>
<term>Sous-type H5N1 du virus de la grippe A (génétique)</term>
<term>Sous-type H5N1 du virus de la grippe A (pathogénicité)</term>
<term>Séquence d'acides aminés</term>
<term>Virulence</term>
<term>Virus de la grippe A (enzymologie)</term>
<term>Virus de la grippe A (génétique)</term>
<term>Virus de la grippe A (pathogénicité)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>RNA Replicase</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term>
<term>Interferon-beta</term>
<term>RNA Replicase</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term>
<term>Interferon-beta</term>
<term>RNA Replicase</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Sous-type H5N1 du virus de la grippe A</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A Virus, H5N1 Subtype</term>
<term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A Virus, H5N1 Subtype</term>
<term>Influenza A virus</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Grippe humaine</term>
<term>Interféron bêta</term>
<term>Protéines adaptatrices de la transduction du signal</term>
<term>Protéines virales</term>
<term>RNA replicase</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Sous-type H5N1 du virus de la grippe A</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Grippe humaine</term>
<term>Interféron bêta</term>
<term>Protéines adaptatrices de la transduction du signal</term>
<term>Protéines virales</term>
<term>RNA replicase</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A Virus, H5N1 Subtype</term>
<term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Sous-type H5N1 du virus de la grippe A</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Down-Regulation</term>
<term>Female</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Molecular Sequence Data</term>
<term>Protein Binding</term>
<term>Sequence Alignment</term>
<term>Virulence</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term>
<term>Animaux</term>
<term>Données de séquences moléculaires</term>
<term>Femelle</term>
<term>Humains</term>
<term>Interactions hôte-pathogène</term>
<term>Liaison aux protéines</term>
<term>Protéines virales</term>
<term>RNA replicase</term>
<term>Régulation négative</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Séquence d'acides aminés</term>
<term>Virulence</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The PB2 subunit of the influenza virus RNA polymerase is a major virulence determinant of influenza viruses. However, the molecular mechanisms involved remain unknown. It was previously shown that the PB2 protein, in addition to its nuclear localization, also accumulates in the mitochondria. Here, we demonstrate that the PB2 protein interacts with the mitochondrial antiviral signaling protein, MAVS (also known as IPS-1, VISA, or Cardif), and inhibits MAVS-mediated beta interferon (IFN-β) expression. In addition, we show that PB2 proteins of influenza viruses differ in their abilities to associate with the mitochondria. In particular, the PB2 proteins of seasonal human influenza viruses localize to the mitochondria while PB2 proteins of avian influenza viruses are nonmitochondrial. This difference in localization is caused by a single amino acid polymorphism in the PB2 mitochondrial targeting signal. In order to address the functional significance of the mitochondrial localization of the PB2 protein <italic>in vivo</italic>
, we have generated two recombinant human influenza viruses encoding either mitochondrial or nonmitochondrial PB2 proteins. We found that the difference in the mitochondrial localization of the PB2 proteins does not affect the growth of these viruses in cell culture. However, the virus encoding the nonmitochondrial PB2 protein induces higher levels of IFN-β and, in an animal model, is attenuated compared to the isogenic virus encoding a mitochondrial PB2. Overall this study implicates the PB2 protein in the regulation of host antiviral innate immune pathways and suggests an important role for the mitochondrial association of the PB2 protein in determining virulence.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Carr, Simon M" sort="Carr, Simon M" uniqKey="Carr S" first="Simon M." last="Carr">Simon M. Carr</name>
<name sortKey="Fodor, Ervin" sort="Fodor, Ervin" uniqKey="Fodor E" first="Ervin" last="Fodor">Ervin Fodor</name>
<name sortKey="Graef, Katy M" sort="Graef, Katy M" uniqKey="Graef K" first="Katy M." last="Graef">Katy M. Graef</name>
<name sortKey="Lau, Yuk Fai" sort="Lau, Yuk Fai" uniqKey="Lau Y" first="Yuk-Fai" last="Lau">Yuk-Fai Lau</name>
<name sortKey="Mccall, Amber W" sort="Mccall, Amber W" uniqKey="Mccall A" first="Amber W." last="Mccall">Amber W. Mccall</name>
<name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
<name sortKey="Vreede, Frank T" sort="Vreede, Frank T" uniqKey="Vreede F" first="Frank T." last="Vreede">Frank T. Vreede</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E09 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000E09 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:2919034 |texte= The PB2 Subunit of the Influenza Virus RNA Polymerase Affects Virulence by Interacting with the Mitochondrial Antiviral Signaling Protein and Inhibiting Expression of Beta Interferon▿ }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:20538852" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a H2N2V1
This area was generated with Dilib version V0.6.33. |