A live attenuated H7N3 influenza virus vaccine is well tolerated and immunogenic in a Phase I trial in healthy adults.
Identifieur interne : 001132 ( Main/Exploration ); précédent : 001131; suivant : 001133A live attenuated H7N3 influenza virus vaccine is well tolerated and immunogenic in a Phase I trial in healthy adults.
Auteurs : Kawsar R. Talaat [États-Unis] ; Ruth A. Karron ; Karen A. Callahan ; Catherine J. Luke ; Susan C. Dilorenzo ; Grace L. Chen ; Elaine W. Lamirande ; Hong Jin ; Kathy L. Coelingh ; Brian R. Murphy ; George Kemble ; Kanta SubbaraoSource :
- Vaccine [ 1873-2518 ] ; 2009.
Descripteurs français
- KwdFr :
- Administration par voie nasale, Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antiviraux (sang), Femelle, Grippe humaine (), Humains, Immunoglobuline A (sang), Immunoglobuline G (sang), Jeune adulte, Mâle, Rappel de vaccin, Test ELISA, Tests d'inhibition de l'hémagglutination, Tests de neutralisation, Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (effets indésirables), Vaccins antigrippaux (immunologie), Vaccins atténués (administration et posologie), Vaccins atténués (effets indésirables), Vaccins atténués (immunologie), Virus de la grippe A (immunologie).
- MESH :
- administration et posologie : Vaccins antigrippaux, Vaccins atténués.
- effets indésirables : Vaccins antigrippaux, Vaccins atténués.
- immunologie : Vaccins antigrippaux, Vaccins atténués, Virus de la grippe A.
- sang : Anticorps antiviraux, Immunoglobuline A, Immunoglobuline G.
- Administration par voie nasale, Adolescent, Adulte, Adulte d'âge moyen, Animaux, Femelle, Grippe humaine, Humains, Jeune adulte, Mâle, Rappel de vaccin, Test ELISA, Tests d'inhibition de l'hémagglutination, Tests de neutralisation.
English descriptors
- KwdEn :
- Administration, Intranasal, Adolescent, Adult, Animals, Antibodies, Viral (blood), Enzyme-Linked Immunosorbent Assay, Female, Hemagglutination Inhibition Tests, Humans, Immunization, Secondary, Immunoglobulin A (blood), Immunoglobulin G (blood), Influenza A virus (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (adverse effects), Influenza Vaccines (immunology), Influenza, Human (prevention & control), Male, Middle Aged, Neutralization Tests, Vaccines, Attenuated (administration & dosage), Vaccines, Attenuated (adverse effects), Vaccines, Attenuated (immunology), Young Adult.
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, Attenuated.
- chemical , adverse effects : Influenza Vaccines, Vaccines, Attenuated.
- chemical , blood : Antibodies, Viral, Immunoglobulin A, Immunoglobulin G.
- immunology : Influenza A virus, Influenza Vaccines, Vaccines, Attenuated.
- prevention & control : Influenza, Human.
- Administration, Intranasal, Adolescent, Adult, Animals, Enzyme-Linked Immunosorbent Assay, Female, Hemagglutination Inhibition Tests, Humans, Immunization, Secondary, Male, Middle Aged, Neutralization Tests, Young Adult.
Abstract
Live attenuated influenza vaccines (LAIVs) are being developed and tested against a variety of influenza viruses with pandemic potential. We describe the results of an open-label Phase I trial of a live attenuated H7N3 virus vaccine.
DOI: 10.1016/j.vaccine.2009.03.082
PubMed: 19464558
Affiliations:
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Le document en format XML
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<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Female</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Immunization, Secondary</term>
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<term>Jeune adulte</term>
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<term>Rappel de vaccin</term>
<term>Test ELISA</term>
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<front><div type="abstract" xml:lang="en">Live attenuated influenza vaccines (LAIVs) are being developed and tested against a variety of influenza viruses with pandemic potential. We describe the results of an open-label Phase I trial of a live attenuated H7N3 virus vaccine.</div>
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<tree><noCountry><name sortKey="Callahan, Karen A" sort="Callahan, Karen A" uniqKey="Callahan K" first="Karen A" last="Callahan">Karen A. Callahan</name>
<name sortKey="Chen, Grace L" sort="Chen, Grace L" uniqKey="Chen G" first="Grace L" last="Chen">Grace L. Chen</name>
<name sortKey="Coelingh, Kathy L" sort="Coelingh, Kathy L" uniqKey="Coelingh K" first="Kathy L" last="Coelingh">Kathy L. Coelingh</name>
<name sortKey="Dilorenzo, Susan C" sort="Dilorenzo, Susan C" uniqKey="Dilorenzo S" first="Susan C" last="Dilorenzo">Susan C. Dilorenzo</name>
<name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name>
<name sortKey="Karron, Ruth A" sort="Karron, Ruth A" uniqKey="Karron R" first="Ruth A" last="Karron">Ruth A. Karron</name>
<name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name>
<name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W" last="Lamirande">Elaine W. Lamirande</name>
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<name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
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<country name="États-Unis"><noRegion><name sortKey="Talaat, Kawsar R" sort="Talaat, Kawsar R" uniqKey="Talaat K" first="Kawsar R" last="Talaat">Kawsar R. Talaat</name>
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