Amino acid sequence analysis and identification of mutations under positive selection in hemagglutinin of 2009 influenza A (H1N1) isolates
Identifieur interne : 000F77 ( Main/Exploration ); précédent : 000F76; suivant : 000F78Amino acid sequence analysis and identification of mutations under positive selection in hemagglutinin of 2009 influenza A (H1N1) isolates
Auteurs : Xiaofan Ding [République populaire de Chine] ; Lifang Jiang [République populaire de Chine] ; Changwen Ke [République populaire de Chine] ; Zhan Yang [République populaire de Chine] ; Chunliang Lei [République populaire de Chine] ; Kaiyuan Cao [République populaire de Chine] ; Jun Xu [République populaire de Chine] ; Lin Xu [République populaire de Chine] ; Xingfen Yang [République populaire de Chine] ; Yonghui Zhang [République populaire de Chine] ; Ping Huang [République populaire de Chine] ; Weijun Huang [République populaire de Chine] ; Xun Zhu [République populaire de Chine] ; Zhenjian He [République populaire de Chine] ; Liping Liu [République populaire de Chine] ; Jun Li [République populaire de Chine] ; Jie Yuan [République populaire de Chine] ; Jueheng Wu [République populaire de Chine] ; Xiaoping Tang [République populaire de Chine] ; Mengfeng Li [République populaire de Chine]Source :
- Virus Genes [ 0920-8569 ] ; 2010-12-01.
English descriptors
Abstract
Abstract: The 2009 flu pandemic is caused by a new strain of influenza A (H1N1) virus, A/H1N1/09. With its high transmissibility, this novel virus has caused a pandemic and infected over 600,000 people globally. By comparing the hemaglutinin (HA) gene and protein sequences among over 700 A/H1N1/09 isolates, mutations in the receptor-binding sites and antigenic epitope regions were identified. Among these mutations, T220 and E/G239 were found to be strongly positively selected over the course of spreading of the A/H1N1/09 virus worldwide. Interestingly, both sites are located in the highly variable epitope regions of HA1, and residue 239 also plays an important role in the receptor-binding process. Further analyses demonstrated that the percentage of T220 mutants among all isolates increased rapidly during the evolution, and that an E/G239 mutation could decrease the binding affinity of the virus with its cellular receptor. Thus, due to a potential functional importance of residues 220 and 239, mutations at these sites, as well as the significant of positive selection on these sites deserves more attention, while new vaccines and therapeutic drugs are developed against this novel virus.
Url:
DOI: 10.1007/s11262-010-0526-z
Affiliations:
Links toward previous steps (curation, corpus...)
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Abstract: The 2009 flu pandemic is caused by a new strain of influenza A (H1N1) virus, A/H1N1/09. With its high transmissibility, this novel virus has caused a pandemic and infected over 600,000 people globally. By comparing the hemaglutinin (HA) gene and protein sequences among over 700 A/H1N1/09 isolates, mutations in the receptor-binding sites and antigenic epitope regions were identified. Among these mutations, T220 and E/G239 were found to be strongly positively selected over the course of spreading of the A/H1N1/09 virus worldwide. Interestingly, both sites are located in the highly variable epitope regions of HA1, and residue 239 also plays an important role in the receptor-binding process. Further analyses demonstrated that the percentage of T220 mutants among all isolates increased rapidly during the evolution, and that an E/G239 mutation could decrease the binding affinity of the virus with its cellular receptor. Thus, due to a potential functional importance of residues 220 and 239, mutations at these sites, as well as the significant of positive selection on these sites deserves more attention, while new vaccines and therapeutic drugs are developed against this novel virus.</div>
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<name sortKey="Cao, Kaiyuan" sort="Cao, Kaiyuan" uniqKey="Cao K" first="Kaiyuan" last="Cao">Kaiyuan Cao</name>
<name sortKey="Cao, Kaiyuan" sort="Cao, Kaiyuan" uniqKey="Cao K" first="Kaiyuan" last="Cao">Kaiyuan Cao</name>
<name sortKey="Ding, Xiaofan" sort="Ding, Xiaofan" uniqKey="Ding X" first="Xiaofan" last="Ding">Xiaofan Ding</name>
<name sortKey="He, Zhenjian" sort="He, Zhenjian" uniqKey="He Z" first="Zhenjian" last="He">Zhenjian He</name>
<name sortKey="He, Zhenjian" sort="He, Zhenjian" uniqKey="He Z" first="Zhenjian" last="He">Zhenjian He</name>
<name sortKey="Huang, Ping" sort="Huang, Ping" uniqKey="Huang P" first="Ping" last="Huang">Ping Huang</name>
<name sortKey="Huang, Weijun" sort="Huang, Weijun" uniqKey="Huang W" first="Weijun" last="Huang">Weijun Huang</name>
<name sortKey="Jiang, Lifang" sort="Jiang, Lifang" uniqKey="Jiang L" first="Lifang" last="Jiang">Lifang Jiang</name>
<name sortKey="Jiang, Lifang" sort="Jiang, Lifang" uniqKey="Jiang L" first="Lifang" last="Jiang">Lifang Jiang</name>
<name sortKey="Ke, Changwen" sort="Ke, Changwen" uniqKey="Ke C" first="Changwen" last="Ke">Changwen Ke</name>
<name sortKey="Lei, Chunliang" sort="Lei, Chunliang" uniqKey="Lei C" first="Chunliang" last="Lei">Chunliang Lei</name>
<name sortKey="Li, Jun" sort="Li, Jun" uniqKey="Li J" first="Jun" last="Li">Jun Li</name>
<name sortKey="Li, Jun" sort="Li, Jun" uniqKey="Li J" first="Jun" last="Li">Jun Li</name>
<name sortKey="Li, Mengfeng" sort="Li, Mengfeng" uniqKey="Li M" first="Mengfeng" last="Li">Mengfeng Li</name>
<name sortKey="Li, Mengfeng" sort="Li, Mengfeng" uniqKey="Li M" first="Mengfeng" last="Li">Mengfeng Li</name>
<name sortKey="Li, Mengfeng" sort="Li, Mengfeng" uniqKey="Li M" first="Mengfeng" last="Li">Mengfeng Li</name>
<name sortKey="Liu, Liping" sort="Liu, Liping" uniqKey="Liu L" first="Liping" last="Liu">Liping Liu</name>
<name sortKey="Liu, Liping" sort="Liu, Liping" uniqKey="Liu L" first="Liping" last="Liu">Liping Liu</name>
<name sortKey="Tang, Xiaoping" sort="Tang, Xiaoping" uniqKey="Tang X" first="Xiaoping" last="Tang">Xiaoping Tang</name>
<name sortKey="Wu, Jueheng" sort="Wu, Jueheng" uniqKey="Wu J" first="Jueheng" last="Wu">Jueheng Wu</name>
<name sortKey="Wu, Jueheng" sort="Wu, Jueheng" uniqKey="Wu J" first="Jueheng" last="Wu">Jueheng Wu</name>
<name sortKey="Xu, Jun" sort="Xu, Jun" uniqKey="Xu J" first="Jun" last="Xu">Jun Xu</name>
<name sortKey="Xu, Lin" sort="Xu, Lin" uniqKey="Xu L" first="Lin" last="Xu">Lin Xu</name>
<name sortKey="Xu, Lin" sort="Xu, Lin" uniqKey="Xu L" first="Lin" last="Xu">Lin Xu</name>
<name sortKey="Yang, Xingfen" sort="Yang, Xingfen" uniqKey="Yang X" first="Xingfen" last="Yang">Xingfen Yang</name>
<name sortKey="Yang, Zhan" sort="Yang, Zhan" uniqKey="Yang Z" first="Zhan" last="Yang">Zhan Yang</name>
<name sortKey="Yuan, Jie" sort="Yuan, Jie" uniqKey="Yuan J" first="Jie" last="Yuan">Jie Yuan</name>
<name sortKey="Yuan, Jie" sort="Yuan, Jie" uniqKey="Yuan J" first="Jie" last="Yuan">Jie Yuan</name>
<name sortKey="Zhang, Yonghui" sort="Zhang, Yonghui" uniqKey="Zhang Y" first="Yonghui" last="Zhang">Yonghui Zhang</name>
<name sortKey="Zhu, Xun" sort="Zhu, Xun" uniqKey="Zhu X" first="Xun" last="Zhu">Xun Zhu</name>
<name sortKey="Zhu, Xun" sort="Zhu, Xun" uniqKey="Zhu X" first="Xun" last="Zhu">Xun Zhu</name>
</country>
</tree>
</affiliations>
</record>
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