Live attenuated influenza virus vaccines strains with temperature-sensitive defects in P3 protein and nucleoprotein
Identifieur interne : 002A61 ( Main/Exploration ); précédent : 002A60; suivant : 002A62Live attenuated influenza virus vaccines strains with temperature-sensitive defects in P3 protein and nucleoprotein
Auteurs : P. Palese [États-Unis] ; Mary B. Ritchey [États-Unis]Source :
- Virology [ 0042-6822 ] ; 1977.
English descriptors
- Teeft :
- Attenuation, Chanock, Gene order, Genome, Hemagglutinin, Hong kong, Honl, Influenza, Influenza virus, Influenza virus recombinants, Influenza viruses, Kilbourne, Lesion, Mdck cells, Mutant, Mutation, Neuraminidase, Nucleoprotein, Palese, Parent viruses, Recombinant, Recombinant viruses, Richman, Ritchey, Rna, Schulman, Vaccine, Viral, Virology, Virus.
Abstract
Abstract: The temperature-sensitive influenza virus A/Hong Kong/68 (H3N2) ts-1[E] has been used as a prototype live attenuated influenza virus vaccine. Using recently developed techniques to map the genome of influenza viruses and to “genotype” influenza virus recombinants, the temperature-sensitive lesions in the virus were identified. These defects, responsible for the attenuation of the virus, are located in the genes for the P3 protein and the nucleoprotein and are associated with virus-specific RNA synthesis. Hong Kong/68 (H3N2) ts-1[E] virus can also serve as a donor of “attenuation characteristics” for the selection of recombinant strains which have different surface antigens and may be used as vaccine strains in the future. The temperature-sensitive mutations of Hong Kong/68 (H3N2) ts-1[E] virus were previously transferred to recombinant viruses carrying the HO hemagglutinin. The RNAs of 8 of these temperature-sensitive recombinants were analyzed. One of these viruses, R1, classified in group 1 of the Hong Kong mutant virus set was found to possess a ts defect only in the P3 protein. R8, a member of group 2 of the Hong Kong mutant virus set had a ts mutation in the nucleoprotein.
Url:
DOI: 10.1016/0042-6822(77)90090-3
Affiliations:
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Le document en format XML
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Palese</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mount Sinai School of Medicine of CUNY, 5th Avenue and 100th Street, New York, New York 10029</wicri:regionArea><wicri:noRegion>New York 10029</wicri:noRegion></affiliation></author><author><name sortKey="Ritchey, Mary B" sort="Ritchey, Mary B" uniqKey="Ritchey M" first="Mary B." last="Ritchey">Mary B. Ritchey</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mount Sinai School of Medicine of CUNY, 5th Avenue and 100th Street, New York, New York 10029</wicri:regionArea><wicri:noRegion>New York 10029</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Virology</title><title level="j" type="abbrev">YVIRO</title><idno type="ISSN">0042-6822</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1977">1977</date><biblScope unit="volume">78</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="183">183</biblScope><biblScope unit="page" to="191">191</biblScope></imprint><idno type="ISSN">0042-6822</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0042-6822</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Attenuation</term><term>Chanock</term><term>Gene order</term><term>Genome</term><term>Hemagglutinin</term><term>Hong kong</term><term>Honl</term><term>Influenza</term><term>Influenza virus</term><term>Influenza virus recombinants</term><term>Influenza viruses</term><term>Kilbourne</term><term>Lesion</term><term>Mdck cells</term><term>Mutant</term><term>Mutation</term><term>Neuraminidase</term><term>Nucleoprotein</term><term>Palese</term><term>Parent viruses</term><term>Recombinant</term><term>Recombinant viruses</term><term>Richman</term><term>Ritchey</term><term>Rna</term><term>Schulman</term><term>Vaccine</term><term>Viral</term><term>Virology</term><term>Virus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The temperature-sensitive influenza virus A/Hong Kong/68 (H3N2) ts-1[E] has been used as a prototype live attenuated influenza virus vaccine. Using recently developed techniques to map the genome of influenza viruses and to “genotype” influenza virus recombinants, the temperature-sensitive lesions in the virus were identified. These defects, responsible for the attenuation of the virus, are located in the genes for the P3 protein and the nucleoprotein and are associated with virus-specific RNA synthesis. Hong Kong/68 (H3N2) ts-1[E] virus can also serve as a donor of “attenuation characteristics” for the selection of recombinant strains which have different surface antigens and may be used as vaccine strains in the future. The temperature-sensitive mutations of Hong Kong/68 (H3N2) ts-1[E] virus were previously transferred to recombinant viruses carrying the HO hemagglutinin. The RNAs of 8 of these temperature-sensitive recombinants were analyzed. One of these viruses, R1, classified in group 1 of the Hong Kong mutant virus set was found to possess a ts defect only in the P3 protein. R8, a member of group 2 of the Hong Kong mutant virus set had a ts mutation in the nucleoprotein.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Palese, P" sort="Palese, P" uniqKey="Palese P" first="P." last="Palese">P. Palese</name></noRegion><name sortKey="Ritchey, Mary B" sort="Ritchey, Mary B" uniqKey="Ritchey M" first="Mary B." last="Ritchey">Mary B. Ritchey</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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