CTL recognition of adenovirus-transformed cells infected with influenza virus: Lysis by anti-influenza CTL parallels adenovirus-12-induced suppression of class I MHC molecules
Identifieur interne : 002227 ( Main/Exploration ); précédent : 002226; suivant : 002228CTL recognition of adenovirus-transformed cells infected with influenza virus: Lysis by anti-influenza CTL parallels adenovirus-12-induced suppression of class I MHC molecules
Auteurs : Jonathan W. Yewdell [États-Unis] ; Jack R. Bennink [États-Unis] ; Kendra B. Eager [États-Unis] ; Robert P. Ricciardi [États-Unis]Source :
- Virology [ 0042-6822 ] ; 1988.
English descriptors
- Teeft :
Abstract
Abstract: We examined the ability of influenza-specific cytotoxic T lymphocytes to lyse adenovirus-transformed cells infected with influenza virus. Cytotoxic T lymphocyte lysis of Ad12-transformed cells was greatly reduced relative to that of Ad5-transformed cells. Lysability of adenovirus-12-transformed cells was restored in parallel with interferon-γ induced increases in major histocompatibility complex class I gene products. These findings establish that recognition of foreign molecules by self-restricted cytotoxic T lymphocytes is reduced in adenovirus-12-transformed cells. This provides further evidence that Adl 2 tumorigenicity is related to its ability to suppress class I major histocompatability complex molecule expression thereby avoiding recognition by the host immune system.
Url:
DOI: 10.1016/0042-6822(88)90413-8
Affiliations:
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Yewdell</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Wister Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation></author><author><name sortKey="Bennink, Jack R" sort="Bennink, Jack R" uniqKey="Bennink J" first="Jack R." last="Bennink">Jack R. Bennink</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Wister Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation></author><author><name sortKey="Eager, Kendra B" sort="Eager, Kendra B" uniqKey="Eager K" first="Kendra B." last="Eager">Kendra B. 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Ricciardi</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Wister Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Virology</title><title level="j" type="abbrev">YVIRO</title><idno type="ISSN">0042-6822</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1988">1988</date><biblScope unit="volume">162</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="236">236</biblScope><biblScope unit="page" to="238">238</biblScope></imprint><idno type="ISSN">0042-6822</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0042-6822</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>2transformed cells</term><term>Cell lines</term><term>Cytotoxic</term><term>Effector</term><term>Foreign antigens</term><term>Influenza</term><term>Influenza virus</term><term>Lymphocyte</term><term>Lyse</term><term>Lyse cells</term><term>Lysed</term><term>Lysis</term><term>Major histocompatability</term><term>Molecule expression</term><term>Tumorigenicity</term><term>Vaccinia virus</term><term>Viral</term><term>Viral antigens</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: We examined the ability of influenza-specific cytotoxic T lymphocytes to lyse adenovirus-transformed cells infected with influenza virus. Cytotoxic T lymphocyte lysis of Ad12-transformed cells was greatly reduced relative to that of Ad5-transformed cells. Lysability of adenovirus-12-transformed cells was restored in parallel with interferon-γ induced increases in major histocompatibility complex class I gene products. These findings establish that recognition of foreign molecules by self-restricted cytotoxic T lymphocytes is reduced in adenovirus-12-transformed cells. This provides further evidence that Adl 2 tumorigenicity is related to its ability to suppress class I major histocompatability complex molecule expression thereby avoiding recognition by the host immune system.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Yewdell, Jonathan W" sort="Yewdell, Jonathan W" uniqKey="Yewdell J" first="Jonathan W." last="Yewdell">Jonathan W. 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