Measles virus editing provides an additional cysteine-rich protein
Identifieur interne : 002152 ( Main/Exploration ); précédent : 002151; suivant : 002153Measles virus editing provides an additional cysteine-rich protein
Auteurs : Roberto Cattaneo ; Karin Kaelin ; Knut Baczko ; Martin A. BilleterSource :
- Cell [ 0092-8674 ] ; 1989.
English descriptors
- Teeft :
- Additional protein, Additional proteins, Amino, Amino acids, Canine distemper virus, Cattaneo, Cdna, Clone, Codon, Cysteine, Edmonston strain, Encoding, Gene, Genome, Genomic sequence encodes, Heterogeneous populations, Human parainfluenza virus, Insertion, Insertion site, Insertion sites, Kolakofsky, Measles, Measles virus, Measles virus gene expression, Methionine, Mrna, Mrna sources, Mumps virus, Negative strand, Nucleotide, Nucleotide sequence, Other hand, Other paramyxoviruses, Other systems, Paramyxovirus, Personal communication, Phosphoprotein, Plasmid, Potential sites, Protein synthesis, Raven press, Reading frame, Reading frames, Ribosomal frameshifting, Rna, Sendai, Sendai virus, Sequence analysis, Sequencing, Subacute sclerosing panencephalitis, Syncytial virus, Synthetic rnas, Transcription, Vesicular stomatitis virus, Viral transcription, Virol, Virology, Virus, Virus editing.
Abstract
Abstract: The measles virus (MV) phosphoprotein (P) gene encodes two known proteins, P (Mr ≈ 70,000), involved in viral transcription, and, in a different reading frame, C (Mr ≈ 20,000). By a combination of cDNA cloning, cDNA and RNA sequencing, and in vitro translation, we demonstrate here that the MV P gene also expresses a third product (Mr ≈ 46,000) containing the amino-terminal region of P but a different, cysteinerich carboxy-terminal motif. This third protein is translated from mRNAs in which one G residue has been inserted after three genomically encoded Gs, a modification found in about 50% of the P mRNAs. A smaller fraction of transcripts contain several additional G residues.
Url:
DOI: 10.1016/0092-8674(89)90679-X
Affiliations:
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Billeter</name><affiliation><wicri:noCountry code="no comma">Institut für Molekularbiologie I Universität Zürich Hönggerberg 8093 Zürich Switzerland</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Cell</title><title level="j" type="abbrev">CELL</title><idno type="ISSN">0092-8674</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1989">1989</date><biblScope unit="volume">56</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="759">759</biblScope><biblScope unit="page" to="764">764</biblScope></imprint><idno type="ISSN">0092-8674</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0092-8674</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Additional protein</term><term>Additional proteins</term><term>Amino</term><term>Amino acids</term><term>Canine distemper virus</term><term>Cattaneo</term><term>Cdna</term><term>Clone</term><term>Codon</term><term>Cysteine</term><term>Edmonston strain</term><term>Encoding</term><term>Gene</term><term>Genome</term><term>Genomic sequence encodes</term><term>Heterogeneous populations</term><term>Human parainfluenza virus</term><term>Insertion</term><term>Insertion site</term><term>Insertion sites</term><term>Kolakofsky</term><term>Measles</term><term>Measles virus</term><term>Measles virus gene expression</term><term>Methionine</term><term>Mrna</term><term>Mrna sources</term><term>Mumps virus</term><term>Negative strand</term><term>Nucleotide</term><term>Nucleotide sequence</term><term>Other hand</term><term>Other paramyxoviruses</term><term>Other systems</term><term>Paramyxovirus</term><term>Personal communication</term><term>Phosphoprotein</term><term>Plasmid</term><term>Potential sites</term><term>Protein synthesis</term><term>Raven press</term><term>Reading frame</term><term>Reading frames</term><term>Ribosomal frameshifting</term><term>Rna</term><term>Sendai</term><term>Sendai virus</term><term>Sequence analysis</term><term>Sequencing</term><term>Subacute sclerosing panencephalitis</term><term>Syncytial virus</term><term>Synthetic rnas</term><term>Transcription</term><term>Vesicular stomatitis virus</term><term>Viral transcription</term><term>Virol</term><term>Virology</term><term>Virus</term><term>Virus editing</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The measles virus (MV) phosphoprotein (P) gene encodes two known proteins, P (Mr ≈ 70,000), involved in viral transcription, and, in a different reading frame, C (Mr ≈ 20,000). By a combination of cDNA cloning, cDNA and RNA sequencing, and in vitro translation, we demonstrate here that the MV P gene also expresses a third product (Mr ≈ 46,000) containing the amino-terminal region of P but a different, cysteinerich carboxy-terminal motif. This third protein is translated from mRNAs in which one G residue has been inserted after three genomically encoded Gs, a modification found in about 50% of the P mRNAs. A smaller fraction of transcripts contain several additional G residues.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Baczko, Knut" sort="Baczko, Knut" uniqKey="Baczko K" first="Knut" last="Baczko">Knut Baczko</name><name sortKey="Billeter, Martin A" sort="Billeter, Martin A" uniqKey="Billeter M" first="Martin A." last="Billeter">Martin A. Billeter</name><name sortKey="Cattaneo, Roberto" sort="Cattaneo, Roberto" uniqKey="Cattaneo R" first="Roberto" last="Cattaneo">Roberto Cattaneo</name><name sortKey="Kaelin, Karin" sort="Kaelin, Karin" uniqKey="Kaelin K" first="Karin" last="Kaelin">Karin Kaelin</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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