H2N2V1, Main, Exploration, bibRecord, 001E88

Comparative Trial of Large-Particle Aerosol and Nose Drop Administration of Live Attenuated Influenza Vaccines

Identifieur interne : 001E88 ( Main/Exploration ); précédent : 001E87; suivant : 001E89

Comparative Trial of Large-Particle Aerosol and Nose Drop Administration of Live Attenuated Influenza Vaccines

Auteurs : William C. Gruber [États-Unis] ; Hattie P. Hinson [États-Unis] ; Kathy L. Holland [États-Unis] ; Juliette M. Thompson [États-Unis] ; George W. Reed [États-Unis] ; Peter F. Wright [États-Unis]

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 1993.

RBID : ISTEX:FF07394531F4CCCA10E767C1D250500F18EEB6B6

Abstract

Healthy adult subjects (n = 198) were randomized to receive bivalent cold-adapted (ca) influenza A vaccine containing 107.4TCID50each of A/Kawasaki/9/86 (H1N1) and A/Los Angeles/2/87 (H3N2) by either nose drops (ND) or large-particle aerosol (LPA). All subjects had received monovalent inactivated influenza Bvaccine intramuscularly in the previous year. Ninety percent of LPA recipients and 82% of ND recipients preferred intranasal administration to their previous experience with intramuscular vaccine. Twenty-six (27%) of 98 LPA recipients and 47 (49%) of97 ND recipients reported swallowing vaccine (P = .008). Fever was observed uncommonly (⩾5%), and incidence of respiratory symptoms was comparable between groups. Fourfold or greater hemagglutination antibody response to at least one of the influenza A vaccine viruses was significantly more frequent after LPA (64%) than ND vaccination (43%; P = .005). LPA administration of ca influenza to the nasopharynx was well tolerated, safe, and more immunogenic than ND delivery.

Url:

https://api.istex.fr/ark:/67375/HXZ-S83DKK8F-0/fulltext.pdf

DOI: 10.1093/infdis/168.5.1282

Affiliations:

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Le document en format XML

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<front><div type="abstract">Healthy adult subjects (n = 198) were randomized to receive bivalent cold-adapted (ca) influenza A vaccine containing 107.4TCID50each of A/Kawasaki/9/86 (H1N1) and A/Los Angeles/2/87 (H3N2) by either nose drops (ND) or large-particle aerosol (LPA). All subjects had received monovalent inactivated influenza Bvaccine intramuscularly in the previous year. Ninety percent of LPA recipients and 82% of ND recipients preferred intranasal administration to their previous experience with intramuscular vaccine. Twenty-six (27%) of 98 LPA recipients and 47 (49%) of97 ND recipients reported swallowing vaccine (P = .008). Fever was observed uncommonly (⩾5%), and incidence of respiratory symptoms was comparable between groups. Fourfold or greater hemagglutination antibody response to at least one of the influenza A vaccine viruses was significantly more frequent after LPA (64%) than ND vaccination (43%; P = .005). LPA administration of ca influenza to the nasopharynx was well tolerated, safe, and more immunogenic than ND delivery.</div>
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Comparative Trial of Large-Particle Aerosol and Nose Drop Administration of Live Attenuated Influenza Vaccines

Comparative Trial of Large-Particle Aerosol and Nose Drop Administration of Live Attenuated Influenza Vaccines

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Abstract

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