Class I Major Histocompatibility Complex-Restricted Cytotoxic T Lymphocytes Are Not Necessary For Heterotypic Immunity To Influenza
Identifieur interne : 001E09 ( Main/Exploration ); précédent : 001E08; suivant : 001E10Class I Major Histocompatibility Complex-Restricted Cytotoxic T Lymphocytes Are Not Necessary For Heterotypic Immunity To Influenza
Auteurs : Bradley S. Bender [États-Unis] ; Wade E. Bell ; Scott Taylor ; Parker A. SmallSource :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1994.
Abstract
Mice transgenic for p2-micrQglobulin deletion (β2 M-/-) were immunized intranasally with either a recombinant vaccinia virus that expressed both nucleoprotein and interleukin-2 or by infection with H3N2 influenza virus; 3–4 weeks later they were challenged with H1N1 influenza virus. The immunized β2 M-/- mice had increased survival and enhanced clearance of virus relative to nonimmune controls. This protection correlated with the development of class II major histocompatibility complex-restricted pulmonary cytotoxic T lymphocyte activity and nasal IgA anti-nucleoprotein antibody. Heterotypic immunity can therefore be generated by a mechanism that does not involve class I major histocompatibility complex-restricted T cells.
Url:
DOI: 10.1093/infdis/170.5.1195
Affiliations:
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Bender</name><affiliation></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Reprints or correspondence: Dr. Bradley S. Bender, GRECC (182), VA Medical Center, Gainesville</wicri:cityArea></affiliation></author><author><name sortKey="Bell, Wade E" sort="Bell, Wade E" uniqKey="Bell W" first="Wade E." last="Bell">Wade E. Bell</name><affiliation><wicri:noCountry code="subField">Gainesville</wicri:noCountry></affiliation></author><author><name sortKey="Taylor, Scott" sort="Taylor, Scott" uniqKey="Taylor S" first="Scott" last="Taylor">Scott Taylor</name><affiliation><wicri:noCountry code="subField">Gainesville</wicri:noCountry></affiliation></author><author><name sortKey="Small, Parker A" sort="Small, Parker A" uniqKey="Small P" first="Parker A." last="Small">Parker A. Small</name><affiliation><wicri:noCountry code="subField">Gainesville</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1994-11">1994</date><biblScope unit="vol">170</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="1195">1195</biblScope><biblScope unit="page" to="1200">1200</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Mice transgenic for p2-micrQglobulin deletion (β2 M-/-) were immunized intranasally with either a recombinant vaccinia virus that expressed both nucleoprotein and interleukin-2 or by infection with H3N2 influenza virus; 3–4 weeks later they were challenged with H1N1 influenza virus. The immunized β2 M-/- mice had increased survival and enhanced clearance of virus relative to nonimmune controls. This protection correlated with the development of class II major histocompatibility complex-restricted pulmonary cytotoxic T lymphocyte activity and nasal IgA anti-nucleoprotein antibody. Heterotypic immunity can therefore be generated by a mechanism that does not involve class I major histocompatibility complex-restricted T cells.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li></region></list><tree><noCountry><name sortKey="Bell, Wade E" sort="Bell, Wade E" uniqKey="Bell W" first="Wade E." last="Bell">Wade E. Bell</name><name sortKey="Small, Parker A" sort="Small, Parker A" uniqKey="Small P" first="Parker A." last="Small">Parker A. Small</name><name sortKey="Taylor, Scott" sort="Taylor, Scott" uniqKey="Taylor S" first="Scott" last="Taylor">Scott Taylor</name></noCountry><country name="États-Unis"><region name="Floride"><name sortKey="Bender, Bradley S" sort="Bender, Bradley S" uniqKey="Bender B" first="Bradley S." last="Bender">Bradley S. Bender</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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