Molecular characterization of the surface glycoprotein genes of an H5N1 influenza virus isolated from a human in Guangdong, China
Identifieur interne : 001429 ( Main/Exploration ); précédent : 001428; suivant : 001430Molecular characterization of the surface glycoprotein genes of an H5N1 influenza virus isolated from a human in Guangdong, China
Auteurs : J.-J. Zhou [République populaire de Chine] ; J. Fu [République populaire de Chine] ; D.-Y. Fang [République populaire de Chine] ; H.-J. Yan [République populaire de Chine] ; J. Tian [République populaire de Chine] ; J.-M. Zhou [République populaire de Chine] ; J.-P. Tao [République populaire de Chine] ; Y. Liang [République populaire de Chine] ; L.-F. Jiang [République populaire de Chine]Source :
- Archives of Virology [ 0304-8608 ] ; 2007-08-01.
Abstract
Summary: In March 2006, a human H5N1-infected case was found in Guangdong province, China. Here, we molecularly characterized the hemagglutinin (HA) and neuraminidase (NA) genes of the A/China/GD01/06 (GD01) strain causing the infection. The phylogenetic analyses suggested that the HA and NA genes of GD01 and recent human H5N1 viruses from different provinces of China were probably derived from a common ancestor and the H5N1 human infection was acquired directly from affected poultry. At the cleavage site of HA, GD01 contained multiple basic amino acids, a feature characteristic of highly pathogenic avian influenza A viruses. The virus possessed Gln222, Gly224, Ser223, Asn182, Gln192 residues adjacent to the receptor-binding site, preferential for recognizing SAα2, 3Gal. In addition, the GD01 NA amino acid sequence possessed Asn344 and Phe466, which might be related to the low-pH stability of the sialidase activity and gastrointestinal symptoms of the patient.
Url:
DOI: 10.1007/s00705-007-0985-2
Affiliations:
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Jiang</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Archives of Virology</title><title level="j" type="sub">Official Journal of the Virology Division of the International Union of Microbiological Societies</title><title level="j" type="abbrev">Arch Virol</title><idno type="ISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="2007-08-01">2007-08-01</date><biblScope unit="volume">152</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1515">1515</biblScope><biblScope unit="page" to="1521">1521</biblScope></imprint><idno type="ISSN">0304-8608</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-8608</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: In March 2006, a human H5N1-infected case was found in Guangdong province, China. Here, we molecularly characterized the hemagglutinin (HA) and neuraminidase (NA) genes of the A/China/GD01/06 (GD01) strain causing the infection. The phylogenetic analyses suggested that the HA and NA genes of GD01 and recent human H5N1 viruses from different provinces of China were probably derived from a common ancestor and the H5N1 human infection was acquired directly from affected poultry. At the cleavage site of HA, GD01 contained multiple basic amino acids, a feature characteristic of highly pathogenic avian influenza A viruses. The virus possessed Gln222, Gly224, Ser223, Asn182, Gln192 residues adjacent to the receptor-binding site, preferential for recognizing SAα2, 3Gal. In addition, the GD01 NA amino acid sequence possessed Asn344 and Phe466, which might be related to the low-pH stability of the sialidase activity and gastrointestinal symptoms of the patient.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li></settlement></list><tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Zhou, J J" sort="Zhou, J J" uniqKey="Zhou J" first="J.-J." last="Zhou">J.-J. Zhou</name></region><name sortKey="Fang, D Y" sort="Fang, D Y" uniqKey="Fang D" first="D.-Y." last="Fang">D.-Y. Fang</name><name sortKey="Fu, J" sort="Fu, J" uniqKey="Fu J" first="J." last="Fu">J. Fu</name><name sortKey="Jiang, L F" sort="Jiang, L F" uniqKey="Jiang L" first="L.-F." last="Jiang">L.-F. Jiang</name><name sortKey="Liang, Y" sort="Liang, Y" uniqKey="Liang Y" first="Y." last="Liang">Y. Liang</name><name sortKey="Tao, J P" sort="Tao, J P" uniqKey="Tao J" first="J.-P." last="Tao">J.-P. Tao</name><name sortKey="Tian, J" sort="Tian, J" uniqKey="Tian J" first="J." last="Tian">J. Tian</name><name sortKey="Yan, H J" sort="Yan, H J" uniqKey="Yan H" first="H.-J." last="Yan">H.-J. Yan</name><name sortKey="Zhou, J M" sort="Zhou, J M" uniqKey="Zhou J" first="J.-M." last="Zhou">J.-M. Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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