H2N2V1, Main, Exploration, bibRecord, 001395

Ab and T cell epitopes of influenza A virus, knowledge and opportunities

Identifieur interne : 001395 ( Main/Exploration ); précédent : 001394; suivant : 001396

Ab and T cell epitopes of influenza A virus, knowledge and opportunities

Auteurs : Huynh-Hoa Bui [États-Unis] ; Bjoern Peters [États-Unis] ; Erika Assarsson [États-Unis] ; Innocent Mbawuike [États-Unis] ; Alessandro Sette [États-Unis]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2007.

RBID : PMC:1765443

Abstract

The Immune Epitope Database and Analysis Resources (IEDB) (www.immuneepitope.org) was recently developed to capture epitope related data. IEDB also hosts various bioinformatics tools that can be used to identify novel epitopes as well as to analyze and visualize existing epitope data. Herein, a comprehensive analysis was undertaken (i) to compile and inventory existing knowledge regarding influenza A epitopes and (ii) to determine possible cross-reactivities of identified epitopes among avian H5N1 and human influenza strains. At present, IEDB contains >600 different epitopes derived from 58 different strains and 10 influenza A proteins. By using the IEDB analysis resources, conservancy analyses were performed, and several conserved and possibly cross-reactive epitopes were identified. Significant gaps in the current knowledge were also revealed, including paucity of Ab epitopes in comparison with T cell epitopes, limited number of epitopes reported for avian influenza strains/subtypes, and limited number of epitopes reported from proteins other than hemagglutinin and nucleoprotein. This analysis provides a resource for researchers to access existing influenza epitope data. At the same time, the analysis illustrates gaps in our collective knowledge that should inspire directions for further study of immunity against the influenza A virus.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1765443

DOI: 10.1073/pnas.0609330104
PubMed: 17200302
PubMed Central: 1765443

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ab and T cell epitopes of influenza A virus, knowledge and opportunities</title>
<author><name sortKey="Bui, Huynh Hoa" sort="Bui, Huynh Hoa" uniqKey="Bui H" first="Huynh-Hoa" last="Bui">Huynh-Hoa Bui</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">*Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037; and</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>*Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Peters, Bjoern" sort="Peters, Bjoern" uniqKey="Peters B" first="Bjoern" last="Peters">Bjoern Peters</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">*Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037; and</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>*Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Assarsson, Erika" sort="Assarsson, Erika" uniqKey="Assarsson E" first="Erika" last="Assarsson">Erika Assarsson</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">*Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037; and</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>*Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mbawuike, Innocent" sort="Mbawuike, Innocent" uniqKey="Mbawuike I" first="Innocent" last="Mbawuike">Innocent Mbawuike</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Department of Molecular Virology, Baylor College of Medicine, Houston, TX 77030</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Molecular Virology, Baylor College of Medicine, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sette, Alessandro" sort="Sette, Alessandro" uniqKey="Sette A" first="Alessandro" last="Sette">Alessandro Sette</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">*Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037; and</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>*Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">17200302</idno>
<idno type="pmc">1765443</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1765443</idno>
<idno type="RBID">PMC:1765443</idno>
<idno type="doi">10.1073/pnas.0609330104</idno>
<date when="2007">2007</date>
<idno type="wicri:Area/Pmc/Corpus">000764</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000764</idno>
<idno type="wicri:Area/Pmc/Curation">000764</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000764</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000B79</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B79</idno>
<idno type="wicri:Area/Ncbi/Merge">000204</idno>
<idno type="wicri:Area/Ncbi/Curation">000204</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000204</idno>
<idno type="wicri:doubleKey">0027-8424:2007:Bui H:ab:and:t</idno>
<idno type="wicri:Area/Main/Merge">001412</idno>
<idno type="wicri:Area/Main/Curation">001395</idno>
<idno type="wicri:Area/Main/Exploration">001395</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Ab and T cell epitopes of influenza A virus, knowledge and opportunities</title>
<author><name sortKey="Bui, Huynh Hoa" sort="Bui, Huynh Hoa" uniqKey="Bui H" first="Huynh-Hoa" last="Bui">Huynh-Hoa Bui</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">*Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037; and</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>*Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Peters, Bjoern" sort="Peters, Bjoern" uniqKey="Peters B" first="Bjoern" last="Peters">Bjoern Peters</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">*Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037; and</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>*Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Assarsson, Erika" sort="Assarsson, Erika" uniqKey="Assarsson E" first="Erika" last="Assarsson">Erika Assarsson</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">*Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037; and</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>*Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mbawuike, Innocent" sort="Mbawuike, Innocent" uniqKey="Mbawuike I" first="Innocent" last="Mbawuike">Innocent Mbawuike</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Department of Molecular Virology, Baylor College of Medicine, Houston, TX 77030</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Molecular Virology, Baylor College of Medicine, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sette, Alessandro" sort="Sette, Alessandro" uniqKey="Sette A" first="Alessandro" last="Sette">Alessandro Sette</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">*Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037; and</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>*Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
<idno type="ISSN">0027-8424</idno>
<idno type="eISSN">1091-6490</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The Immune Epitope Database and Analysis Resources (IEDB) (<ext-link ext-link-type="uri" xlink:href="http://www.immuneepitope.org">www.immuneepitope.org</ext-link>
) was recently developed to capture epitope related data. IEDB also hosts various bioinformatics tools that can be used to identify novel epitopes as well as to analyze and visualize existing epitope data. Herein, a comprehensive analysis was undertaken (<italic>i</italic>
) to compile and inventory existing knowledge regarding influenza A epitopes and (<italic>ii</italic>
) to determine possible cross-reactivities of identified epitopes among avian H5N1 and human influenza strains. At present, IEDB contains >600 different epitopes derived from 58 different strains and 10 influenza A proteins. By using the IEDB analysis resources, conservancy analyses were performed, and several conserved and possibly cross-reactive epitopes were identified. Significant gaps in the current knowledge were also revealed, including paucity of Ab epitopes in comparison with T cell epitopes, limited number of epitopes reported for avian influenza strains/subtypes, and limited number of epitopes reported from proteins other than hemagglutinin and nucleoprotein. This analysis provides a resource for researchers to access existing influenza epitope data. At the same time, the analysis illustrates gaps in our collective knowledge that should inspire directions for further study of immunity against the influenza A virus.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Texas</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Californie"><name sortKey="Bui, Huynh Hoa" sort="Bui, Huynh Hoa" uniqKey="Bui H" first="Huynh-Hoa" last="Bui">Huynh-Hoa Bui</name>
</region>
<name sortKey="Assarsson, Erika" sort="Assarsson, Erika" uniqKey="Assarsson E" first="Erika" last="Assarsson">Erika Assarsson</name>
<name sortKey="Mbawuike, Innocent" sort="Mbawuike, Innocent" uniqKey="Mbawuike I" first="Innocent" last="Mbawuike">Innocent Mbawuike</name>
<name sortKey="Peters, Bjoern" sort="Peters, Bjoern" uniqKey="Peters B" first="Bjoern" last="Peters">Bjoern Peters</name>
<name sortKey="Sette, Alessandro" sort="Sette, Alessandro" uniqKey="Sette A" first="Alessandro" last="Sette">Alessandro Sette</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001395 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001395 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:1765443
   |texte=   Ab and T cell epitopes of influenza A virus, knowledge and opportunities
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:17200302" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a H2N2V1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

Serveur d'exploration H2N2

Ab and T cell epitopes of influenza A virus, knowledge and opportunities

Ab and T cell epitopes of influenza A virus, knowledge and opportunities

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.