Early intrahepatic accumulation of CD8+ T cells provides a source of effectors for nonhepatic immune responses.
Identifieur interne : 001383 ( Main/Exploration ); précédent : 001382; suivant : 001384Early intrahepatic accumulation of CD8+ T cells provides a source of effectors for nonhepatic immune responses.
Auteurs : Noelle K. Polakos [États-Unis] ; Ingo Klein ; Martin V. Richter ; Dietmar M. Zaiss ; Matthew Giannandrea ; Ian N. Crispe ; David J. TophamSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 0022-1767 ] ; 2007.
Descripteurs français
- KwdFr :
- Agrégation cellulaire (immunologie), Animaux, Cinétique, Cytotoxicité immunologique, Foie (cytologie), Foie (immunologie), Foie (métabolisme), Foie (virologie), Immunophénotypage, Infections à Orthomyxoviridae (anatomopathologie), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (métabolisme), Lymphocytes T CD8+ (cytologie), Lymphocytes T CD8+ (immunologie), Lymphocytes T CD8+ (transplantation), Mouvement cellulaire (immunologie), Mémoire immunologique, Poumon (cytologie), Poumon (immunologie), Poumon (virologie), Souris, Souris de lignée BALB C, Souris de lignée C57BL, Souris transgéniques, Sous-type H2N2 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (immunologie), Spécificité d'organe (immunologie), Transfert adoptif, Transplantation hépatique (immunologie).
- MESH :
- anatomopathologie : Infections à Orthomyxoviridae.
- cytologie : Foie, Lymphocytes T CD8+, Poumon.
- immunologie : Agrégation cellulaire, Foie, Infections à Orthomyxoviridae, Lymphocytes T CD8+, Mouvement cellulaire, Poumon, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Spécificité d'organe, Transplantation hépatique.
- métabolisme : Foie, Infections à Orthomyxoviridae.
- virologie : Foie, Poumon.
- transplantation : Animaux, Cinétique, Cytotoxicité immunologique, Immunophénotypage, Lymphocytes T CD8+, Mémoire immunologique, Souris, Souris de lignée BALB C, Souris de lignée C57BL, Souris transgéniques, Transfert adoptif.
English descriptors
- KwdEn :
- Adoptive Transfer, Animals, CD8-Positive T-Lymphocytes (cytology), CD8-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (transplantation), Cell Aggregation (immunology), Cell Movement (immunology), Cytotoxicity, Immunologic, Immunologic Memory, Immunophenotyping, Influenza A Virus, H2N2 Subtype (immunology), Influenza A Virus, H3N2 Subtype (immunology), Kinetics, Liver (cytology), Liver (immunology), Liver (metabolism), Liver (virology), Liver Transplantation (immunology), Lung (cytology), Lung (immunology), Lung (virology), Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Organ Specificity (immunology), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (metabolism), Orthomyxoviridae Infections (pathology).
- MESH :
- cytology : CD8-Positive T-Lymphocytes, Liver, Lung.
- immunology : CD8-Positive T-Lymphocytes, Cell Aggregation, Cell Movement, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Liver, Liver Transplantation, Lung, Organ Specificity, Orthomyxoviridae Infections.
- metabolism : Liver, Orthomyxoviridae Infections.
- pathology : Orthomyxoviridae Infections.
- transplantation : CD8-Positive T-Lymphocytes.
- virology : Liver, Lung.
- Adoptive Transfer, Animals, Cytotoxicity, Immunologic, Immunologic Memory, Immunophenotyping, Kinetics, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic.
Abstract
Interactions between the liver and CD8+ T cells can lead to tolerance, due in part to CD8+ T cell death. To test whether this was the case in an extrahepatic infection, we investigated the fate and effector capacity of intrahepatic CD8+ T cells during lung-restricted influenza infection in mice. Virus-specific T cells accumulated in livers without detectable intrahepatic presentation of viral Ags, and this accumulation was not restricted to the contraction phase, but was apparent as early as day 5. Intrahepatic influenza-specific cells were functionally similar to those recovered from the bronchioalveolar lavage, based on ex vivo cytokine production and specific target lysis. Both adoptive transfer of liver lymphocytes and orthotopic liver transplant of organs containing accumulated effector T cells revealed that activated CD8s from the liver were viable, expanded during reinfection, and generated a memory population that trafficked to lymphoid organs. Thus, intrahepatic CD8+ T cells re-enter circulation and generate functional memory, indicating that the liver does not uniformly incapacitate activated CD8+ T cells. Instead, it constitutes a substantial reservoir of usable Ag-specific effector CD8+ T cells involved in both acute and recall immune responses.
DOI: 10.4049/jimmunol.179.1.201
PubMed: 17579039
Affiliations:
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Crispe</name></author><author><name sortKey="Topham, David J" sort="Topham, David J" uniqKey="Topham D" first="David J" last="Topham">David J. 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Polakos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642</wicri:regionArea><wicri:noRegion>NY 14642</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Ingo" sort="Klein, Ingo" uniqKey="Klein I" first="Ingo" last="Klein">Ingo Klein</name></author><author><name sortKey="Richter, Martin V" sort="Richter, Martin V" uniqKey="Richter M" first="Martin V" last="Richter">Martin V. Richter</name></author><author><name sortKey="Zaiss, Dietmar M" sort="Zaiss, Dietmar M" uniqKey="Zaiss D" first="Dietmar M" last="Zaiss">Dietmar M. Zaiss</name></author><author><name sortKey="Giannandrea, Matthew" sort="Giannandrea, Matthew" uniqKey="Giannandrea M" first="Matthew" last="Giannandrea">Matthew Giannandrea</name></author><author><name sortKey="Crispe, Ian N" sort="Crispe, Ian N" uniqKey="Crispe I" first="Ian N" last="Crispe">Ian N. Crispe</name></author><author><name sortKey="Topham, David J" sort="Topham, David J" uniqKey="Topham D" first="David J" last="Topham">David J. Topham</name></author></analytic><series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title><idno type="ISSN">0022-1767</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adoptive Transfer</term><term>Animals</term><term>CD8-Positive T-Lymphocytes (cytology)</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>CD8-Positive T-Lymphocytes (transplantation)</term><term>Cell Aggregation (immunology)</term><term>Cell Movement (immunology)</term><term>Cytotoxicity, Immunologic</term><term>Immunologic Memory</term><term>Immunophenotyping</term><term>Influenza A Virus, H2N2 Subtype (immunology)</term><term>Influenza A Virus, H3N2 Subtype (immunology)</term><term>Kinetics</term><term>Liver (cytology)</term><term>Liver (immunology)</term><term>Liver (metabolism)</term><term>Liver (virology)</term><term>Liver Transplantation (immunology)</term><term>Lung (cytology)</term><term>Lung (immunology)</term><term>Lung (virology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred C57BL</term><term>Mice, Transgenic</term><term>Organ Specificity (immunology)</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (metabolism)</term><term>Orthomyxoviridae Infections (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agrégation cellulaire (immunologie)</term><term>Animaux</term><term>Cinétique</term><term>Cytotoxicité immunologique</term><term>Foie (cytologie)</term><term>Foie (immunologie)</term><term>Foie (métabolisme)</term><term>Foie (virologie)</term><term>Immunophénotypage</term><term>Infections à Orthomyxoviridae (anatomopathologie)</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Infections à Orthomyxoviridae (métabolisme)</term><term>Lymphocytes T CD8+ (cytologie)</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Lymphocytes T CD8+ (transplantation)</term><term>Mouvement cellulaire (immunologie)</term><term>Mémoire immunologique</term><term>Poumon (cytologie)</term><term>Poumon (immunologie)</term><term>Poumon (virologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris de lignée C57BL</term><term>Souris transgéniques</term><term>Sous-type H2N2 du virus de la grippe A (immunologie)</term><term>Sous-type H3N2 du virus de la grippe A (immunologie)</term><term>Spécificité d'organe (immunologie)</term><term>Transfert adoptif</term><term>Transplantation hépatique (immunologie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Foie</term><term>Lymphocytes T CD8+</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term><term>Liver</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Agrégation cellulaire</term><term>Foie</term><term>Infections à Orthomyxoviridae</term><term>Lymphocytes T CD8+</term><term>Mouvement cellulaire</term><term>Poumon</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Spécificité d'organe</term><term>Transplantation hépatique</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term><term>Cell Aggregation</term><term>Cell Movement</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Liver</term><term>Liver Transplantation</term><term>Lung</term><term>Organ Specificity</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Liver</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Foie</term><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Foie</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Liver</term><term>Lung</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adoptive Transfer</term><term>Animals</term><term>Cytotoxicity, Immunologic</term><term>Immunologic Memory</term><term>Immunophenotyping</term><term>Kinetics</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred C57BL</term><term>Mice, Transgenic</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="fr"><term>Animaux</term><term>Cinétique</term><term>Cytotoxicité immunologique</term><term>Immunophénotypage</term><term>Lymphocytes T CD8+</term><term>Mémoire immunologique</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris de lignée C57BL</term><term>Souris transgéniques</term><term>Transfert adoptif</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Interactions between the liver and CD8+ T cells can lead to tolerance, due in part to CD8+ T cell death. To test whether this was the case in an extrahepatic infection, we investigated the fate and effector capacity of intrahepatic CD8+ T cells during lung-restricted influenza infection in mice. Virus-specific T cells accumulated in livers without detectable intrahepatic presentation of viral Ags, and this accumulation was not restricted to the contraction phase, but was apparent as early as day 5. Intrahepatic influenza-specific cells were functionally similar to those recovered from the bronchioalveolar lavage, based on ex vivo cytokine production and specific target lysis. Both adoptive transfer of liver lymphocytes and orthotopic liver transplant of organs containing accumulated effector T cells revealed that activated CD8s from the liver were viable, expanded during reinfection, and generated a memory population that trafficked to lymphoid organs. Thus, intrahepatic CD8+ T cells re-enter circulation and generate functional memory, indicating that the liver does not uniformly incapacitate activated CD8+ T cells. Instead, it constitutes a substantial reservoir of usable Ag-specific effector CD8+ T cells involved in both acute and recall immune responses.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Crispe, Ian N" sort="Crispe, Ian N" uniqKey="Crispe I" first="Ian N" last="Crispe">Ian N. Crispe</name><name sortKey="Giannandrea, Matthew" sort="Giannandrea, Matthew" uniqKey="Giannandrea M" first="Matthew" last="Giannandrea">Matthew Giannandrea</name><name sortKey="Klein, Ingo" sort="Klein, Ingo" uniqKey="Klein I" first="Ingo" last="Klein">Ingo Klein</name><name sortKey="Richter, Martin V" sort="Richter, Martin V" uniqKey="Richter M" first="Martin V" last="Richter">Martin V. Richter</name><name sortKey="Topham, David J" sort="Topham, David J" uniqKey="Topham D" first="David J" last="Topham">David J. Topham</name><name sortKey="Zaiss, Dietmar M" sort="Zaiss, Dietmar M" uniqKey="Zaiss D" first="Dietmar M" last="Zaiss">Dietmar M. Zaiss</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Polakos, Noelle K" sort="Polakos, Noelle K" uniqKey="Polakos N" first="Noelle K" last="Polakos">Noelle K. Polakos</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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