Relationship of Th1/Th2 cell balance with the immune response to influenza vaccine during pregnancy
Identifieur interne : 001161 ( Main/Exploration ); précédent : 001160; suivant : 001162Relationship of Th1/Th2 cell balance with the immune response to influenza vaccine during pregnancy
Auteurs : Koushi Yamaguchi [Japon] ; Michi Hisano [Japon] ; Sakiko Isojima [Japon] ; Seiko Irie [Japon] ; Naoko Arata [Japon] ; Noriyoshi Watanabe [Japon] ; Takahiko Kubo [Japon] ; Tatsuo Kato [Japon] ; Atsuko Murashima [Japon]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2009-11.
English descriptors
- Teeft :
- Advisory committee, Antibody, Antibody level, Antibody response, Antibody response rate, Antibody titer, Antibody titers, Becton dickinson, Biologics evaluation, Cell activities, Cell balance, Child health, Disease control, Fetal, Fetal blood, Fetal umbilical cord blood, Gestation, Gestational stage, Grant sponsor, Higher titers, Human type, Immune, Immune response, Immune responses, Immunization, Immunization practices, Maternal, Maternal blood, Maternal serum, Mmwr recomm, National center, Optimal timing, Preexisting immunity, Pregnancy, Pregnant women, Prevaccination, Public health, Same antigens, Second trimester, Third trimester, Third trimesters, Titer, Transfer rate, Transplacental, Transplacental transfer, Transplacental transfer rate, Trimester, Vaccinated, Vaccinated subjects, Vaccination, Vaccine, Viral, Viral infections, Viral strains, Virol, Wide range.
Abstract
To determine the optimal timing for influenza vaccination in pregnant women, we measured alterations in the types 1 and 2 T helper cell (Th1/Th2) balance during pregnancy, monitored specific immunity to inoculated antigens after vaccination with inactivated influenza vaccine, evaluated the relevance of the Th1/Th2 ratio and immune responses to the vaccination, monitored the maintenance of high antibody titers until delivery and measured the transplacental antibody transfer rate. No significant alterations of the Th1/Th2 balance were noted in the 65% of pregnant women among whom the Th1/Th2 ratio was lower than 9.9% in the first trimester. In those groups with a ratio higher than 10% in the first trimester, there was a tendency for the ratio to decrease as gestation advanced. The efficiency of immunization was not influenced by the Th1/Th2 status or by the stage of gestation. The antibody titer decreased steadily with time from 1 month after vaccination to the time of delivery. Conversely, the transfer rate of antibodies from maternal to fetal blood at the time of delivery increased with the duration of gestation after vaccination. Nevertheless, the antibody titers in both maternal and fetal blood were sufficient to afford protection against infection. Thus, efficient influenza vaccination can be undertaken at any stage of pregnancy. J. Med. Virol. 81:1923–1928, 2009. © 2009 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.21620
Affiliations:
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type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">81</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1923">1923</biblScope><biblScope unit="page" to="1928">1928</biblScope><biblScope unit="page-count">6</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-11">2009-11</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Advisory committee</term><term>Antibody</term><term>Antibody level</term><term>Antibody response</term><term>Antibody response rate</term><term>Antibody titer</term><term>Antibody titers</term><term>Becton dickinson</term><term>Biologics evaluation</term><term>Cell activities</term><term>Cell balance</term><term>Child health</term><term>Disease control</term><term>Fetal</term><term>Fetal blood</term><term>Fetal umbilical cord blood</term><term>Gestation</term><term>Gestational stage</term><term>Grant sponsor</term><term>Higher titers</term><term>Human type</term><term>Immune</term><term>Immune response</term><term>Immune responses</term><term>Immunization</term><term>Immunization practices</term><term>Maternal</term><term>Maternal blood</term><term>Maternal serum</term><term>Mmwr recomm</term><term>National center</term><term>Optimal timing</term><term>Preexisting immunity</term><term>Pregnancy</term><term>Pregnant women</term><term>Prevaccination</term><term>Public health</term><term>Same antigens</term><term>Second trimester</term><term>Third trimester</term><term>Third trimesters</term><term>Titer</term><term>Transfer rate</term><term>Transplacental</term><term>Transplacental transfer</term><term>Transplacental transfer rate</term><term>Trimester</term><term>Vaccinated</term><term>Vaccinated subjects</term><term>Vaccination</term><term>Vaccine</term><term>Viral</term><term>Viral infections</term><term>Viral strains</term><term>Virol</term><term>Wide range</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine the optimal timing for influenza vaccination in pregnant women, we measured alterations in the types 1 and 2 T helper cell (Th1/Th2) balance during pregnancy, monitored specific immunity to inoculated antigens after vaccination with inactivated influenza vaccine, evaluated the relevance of the Th1/Th2 ratio and immune responses to the vaccination, monitored the maintenance of high antibody titers until delivery and measured the transplacental antibody transfer rate. No significant alterations of the Th1/Th2 balance were noted in the 65% of pregnant women among whom the Th1/Th2 ratio was lower than 9.9% in the first trimester. In those groups with a ratio higher than 10% in the first trimester, there was a tendency for the ratio to decrease as gestation advanced. The efficiency of immunization was not influenced by the Th1/Th2 status or by the stage of gestation. The antibody titer decreased steadily with time from 1 month after vaccination to the time of delivery. Conversely, the transfer rate of antibodies from maternal to fetal blood at the time of delivery increased with the duration of gestation after vaccination. Nevertheless, the antibody titers in both maternal and fetal blood were sufficient to afford protection against infection. Thus, efficient influenza vaccination can be undertaken at any stage of pregnancy. J. Med. Virol. 81:1923–1928, 2009. © 2009 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Yamaguchi, Koushi" sort="Yamaguchi, Koushi" uniqKey="Yamaguchi K" first="Koushi" last="Yamaguchi">Koushi Yamaguchi</name></region><name sortKey="Arata, Naoko" sort="Arata, Naoko" uniqKey="Arata N" first="Naoko" last="Arata">Naoko Arata</name><name sortKey="Arata, Naoko" sort="Arata, Naoko" uniqKey="Arata N" first="Naoko" last="Arata">Naoko Arata</name><name sortKey="Hisano, Michi" sort="Hisano, Michi" uniqKey="Hisano M" first="Michi" last="Hisano">Michi Hisano</name><name sortKey="Irie, Seiko" sort="Irie, Seiko" uniqKey="Irie S" first="Seiko" last="Irie">Seiko Irie</name><name sortKey="Irie, Seiko" sort="Irie, Seiko" uniqKey="Irie S" first="Seiko" last="Irie">Seiko Irie</name><name sortKey="Isojima, Sakiko" sort="Isojima, Sakiko" uniqKey="Isojima S" first="Sakiko" last="Isojima">Sakiko Isojima</name><name sortKey="Kato, Tatsuo" sort="Kato, Tatsuo" uniqKey="Kato T" first="Tatsuo" last="Kato">Tatsuo Kato</name><name sortKey="Kubo, Takahiko" sort="Kubo, Takahiko" uniqKey="Kubo T" first="Takahiko" last="Kubo">Takahiko Kubo</name><name sortKey="Murashima, Atsuko" sort="Murashima, Atsuko" uniqKey="Murashima A" first="Atsuko" last="Murashima">Atsuko Murashima</name><name sortKey="Murashima, Atsuko" sort="Murashima, Atsuko" uniqKey="Murashima A" first="Atsuko" last="Murashima">Atsuko Murashima</name><name sortKey="Watanabe, Noriyoshi" sort="Watanabe, Noriyoshi" uniqKey="Watanabe N" first="Noriyoshi" last="Watanabe">Noriyoshi Watanabe</name><name sortKey="Watanabe, Noriyoshi" sort="Watanabe, Noriyoshi" uniqKey="Watanabe N" first="Noriyoshi" last="Watanabe">Noriyoshi Watanabe</name><name sortKey="Yamaguchi, Koushi" sort="Yamaguchi, Koushi" uniqKey="Yamaguchi K" first="Koushi" last="Yamaguchi">Koushi Yamaguchi</name><name sortKey="Yamaguchi, Koushi" sort="Yamaguchi, Koushi" uniqKey="Yamaguchi K" first="Koushi" last="Yamaguchi">Koushi Yamaguchi</name><name sortKey="Yamaguchi, Koushi" sort="Yamaguchi, Koushi" uniqKey="Yamaguchi K" first="Koushi" last="Yamaguchi">Koushi Yamaguchi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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