Evidence Obtained from anova to Reason Cross‐species Infection and Cross‐subtype Mutation in Neuraminidases of Influenza A Viruses
Identifieur interne : 000F57 ( Main/Exploration ); précédent : 000F56; suivant : 000F58Evidence Obtained from anova to Reason Cross‐species Infection and Cross‐subtype Mutation in Neuraminidases of Influenza A Viruses
Auteurs : S. Yan [République populaire de Chine] ; G. Wu [République populaire de Chine]Source :
- Transboundary and Emerging Diseases [ 1865-1674 ] ; 2010-08.
English descriptors
- Teeft :
- Amino, Amino acid, Amino acid pair, Amino acids, Anova, Antigenic similarity, Avian, Avian virus, Biochem, Biol, Biological functions, Biophys, Blackwell verlag gmbh transboundary, Canine, Chem, Chou, Commun, Comparison test, Crossspecies infection, Current pandemic, Dreamscitech consulting, Drug design, Drug resistance, Enzyme kinetics, Equine, Gmbh, Heterosubtypic immunity, Human vaccine virus, Inhibitor, Mammalian animals, Mutation, Neuraminidase, Neuraminidase inhibitor, Neuraminidase inhibitors, Neuraminidases, Neuraminidases table, Other hand, Pandemic, Predictable portions, Protease cleavage sites, Protein pept, Protein subcellular location prediction, Proton channel, Reason infection, Recent years, Serological subtypes, Shen, Statistical difference, Subtype, Subtypes, Swine, Swine virus, Transboundary, Upper panel, Vaccine, Verlag, Virus, Virus neuraminidase, Wang.
Abstract
The current pandemic of A/H1N1 influenza raises a serious question on cross‐species infection and cross‐subtype mutation because our previous focus on possible influenza pandemic laid on H5N1 subtype and the cross‐species infection between avian and human. In this study, we analyse 3874 neuraminidases from influenza A viruses using anova to answer the question of if there is barrier between species and between subtypes. The results show that there is no cross‐species barrier in some species, and the intra‐species variation is larger than the inter‐species variation in some species hosting the viruses, and the cross‐subtype mutation is possible because there is no cross‐subtype barrier in some subtypes and the intra‐subtype variation is larger than the inter‐subtype variation in some subtypes. These results highlight the state of barrier of influenza A virus, which can help us understand the current pandemic and manufacture more effective vaccines.
Url:
DOI: 10.1111/j.1865-1682.2010.01143.x
Affiliations:
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In this study, we analyse 3874 neuraminidases from influenza A viruses using anova to answer the question of if there is barrier between species and between subtypes. The results show that there is no cross‐species barrier in some species, and the intra‐species variation is larger than the inter‐species variation in some species hosting the viruses, and the cross‐subtype mutation is possible because there is no cross‐subtype barrier in some subtypes and the intra‐subtype variation is larger than the inter‐subtype variation in some subtypes. These results highlight the state of barrier of influenza A virus, which can help us understand the current pandemic and manufacture more effective vaccines.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Yan, S" sort="Yan, S" uniqKey="Yan S" first="S." last="Yan">S. 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