Host Dependent Evolutionary Patterns and the Origin of 2009 H1N1 Pandemic Influenza
Identifieur interne : 000E73 ( Main/Exploration ); précédent : 000E72; suivant : 000E74Host Dependent Evolutionary Patterns and the Origin of 2009 H1N1 Pandemic Influenza
Auteurs : Alexander Solovyov ; Benjamin Greenbaum ; Gustavo Palacios ; W. Ian Lipkin ; Raul RabadanSource :
- PLoS Currents [ 2157-3999 ] ; 2010.
Abstract
The origin of H1N1pdm constitutes an unresolved mystery, as its most recently observed ancestors were isolated in pigs nearly a decade before it emerged in humans. One theory suggests imperfect surveillance of swine viruses caused the virus to be missed in swine herds. Other hypotheses point to the possibility of laboratory error or an avian intermediary. We show substitution bias classification identifies the host where a virus has been evolving. Comparing the evolution of H1N1pdm ancestors with other influenza viruses, we show the evolutionary history in unsampled years is similar to the evolution of other swine viruses, presenting evidence it emerged from unsampled herds.
Url:
DOI: 10.1371/currents.RRN1147
PubMed: 20126278
PubMed Central: 2814059
Affiliations:
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Ian" last="Lipkin">W. Ian Lipkin</name></author><author><name sortKey="Rabadan, Raul" sort="Rabadan, Raul" uniqKey="Rabadan R" first="Raul" last="Rabadan">Raul Rabadan</name></author></analytic><series><title level="j">PLoS Currents</title><idno type="eISSN">2157-3999</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="p1">The origin of H1N1pdm constitutes an unresolved mystery, as its most recently observed ancestors were isolated in pigs nearly a decade before it emerged in humans. One theory suggests imperfect surveillance of swine viruses caused the virus to be missed in swine herds. Other hypotheses point to the possibility of laboratory error or an avian intermediary. We show substitution bias classification identifies the host where a virus has been evolving. Comparing the evolution of H1N1pdm ancestors with other influenza viruses, we show the evolutionary history in unsampled years is similar to the evolution of other swine viruses, presenting evidence it emerged from unsampled herds.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Greenbaum, Benjamin" sort="Greenbaum, Benjamin" uniqKey="Greenbaum B" first="Benjamin" last="Greenbaum">Benjamin Greenbaum</name><name sortKey="Lipkin, W Ian" sort="Lipkin, W Ian" uniqKey="Lipkin W" first="W. Ian" last="Lipkin">W. Ian Lipkin</name><name sortKey="Palacios, Gustavo" sort="Palacios, Gustavo" uniqKey="Palacios G" first="Gustavo" last="Palacios">Gustavo Palacios</name><name sortKey="Rabadan, Raul" sort="Rabadan, Raul" uniqKey="Rabadan R" first="Raul" last="Rabadan">Raul Rabadan</name><name sortKey="Solovyov, Alexander" sort="Solovyov, Alexander" uniqKey="Solovyov A" first="Alexander" last="Solovyov">Alexander Solovyov</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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