H2N2V1, Main, Exploration, bibRecord, 000B98

Use of Toll-Like Receptor 3 Agonists Against Respiratory Viral Infections

Identifieur interne : 000B98 ( Main/Exploration ); précédent : 000B97; suivant : 000B99

Use of Toll-Like Receptor 3 Agonists Against Respiratory Viral Infections

Source :

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry [ 1871-5230 ] ; 2011.

RBID : PMC:3552307

Abstract

Respiratory RNA viruses are constantly evolving, thus requiring development of additional prophylactic and therapeutic strategies. Harnessing the innate immune system to non-specifically respond to viral infection has the advantage of being able to circumvent viral mutations that render the virus resistant to a particular therapeutic agent. Viruses are recognized by various cellular receptors, including Toll-like receptor (TLR) 3 which recognizes double-stranded (ds)RNA produced during the viral replication cycle. TLR3 agonists include synthetic dsRNA such as poly (IC), poly (ICLC) and poly (AU). These agents have been evaluated and found to be effective against a number of viral agents. One major limitation has been the toxicity associated with administration of these drugs. Significant time and effort have been spent to develop alternatives/modifications that will minimize these adverse effects. This review will focus on the TLR3 agonist, poly (IC)/(ICLC) with respect to its use in treatment/prevention of respiratory viral infections.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552307

DOI: 10.2174/187152111800194434
PubMed: NONE
PubMed Central: 3552307

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Respiratory RNA viruses are constantly evolving, thus requiring development of additional prophylactic and
therapeutic strategies. Harnessing the innate immune system to non-specifically respond to viral infection has the
advantage of being able to circumvent viral mutations that render the virus resistant to a particular therapeutic agent.
Viruses are recognized by various cellular receptors, including Toll-like receptor (TLR) 3 which recognizes double-stranded
(ds)RNA produced during the viral replication cycle. TLR3 agonists include synthetic dsRNA such as poly (IC),
poly (ICLC) and poly (AU). These agents have been evaluated and found to be effective against a number of viral agents.
One major limitation has been the toxicity associated with administration of these drugs. Significant time and effort have
been spent to develop alternatives/modifications that will minimize these adverse effects. This review will focus on the
TLR3 agonist, poly (IC)/(ICLC) with respect to its use in treatment/prevention of respiratory viral infections.</p>
</div>
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{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:3552307
   |texte=   Use of Toll-Like Receptor 3 Agonists Against Respiratory Viral Infections
}}

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Serveur d'exploration H2N2

Use of Toll-Like Receptor 3 Agonists Against Respiratory Viral Infections

Use of Toll-Like Receptor 3 Agonists Against Respiratory Viral Infections

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Abstract

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	Serveur d'exploration H2N2
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