The antigenic property of the H5N1 avian influenza viruses isolated in central China
Identifieur interne : 000A03 ( Main/Exploration ); précédent : 000A02; suivant : 000A04The antigenic property of the H5N1 avian influenza viruses isolated in central China
Auteurs : Wei Zou [République populaire de Chine] ; Jianjiang Ke [République populaire de Chine] ; Jiping Zhu [République populaire de Chine] ; Hongbo Zhou [République populaire de Chine] ; Meilin Jin [République populaire de Chine]Source :
- Virology Journal [ 1743-422X ] ; 2012.
Abstract
Three influenza pandemics outbroke in the last century accompanied the viral antigen shift and drift, resulting in the change of antigenic property and the low cross protective ability of the existed antibody to the newly emerged pandemic virus, and eventually the death of millions of people. The antigenic characterizations of the viruses isolated in central China in 2004 and 2006–2007 were investigated in the present study.
Hemagglutinin inhibition assay and neutralization assay displayed differential antigenic characteristics of the viruses isolated in central China in two periods (2004 and 2006–2007). HA genes of the viruses mainly located in two branches in phylogeny analysis. 53 mutations of the deduced amino acids of the HA genes were divided into 4 patterns. Mutations in pattern 2 and 3 showed the main difference between viruses isolated in 2004 and 2006–2007. Meanwhile, most amino acids in pattern 2 and 3 located in the globular head of the HA protein, and some of the mutations evenly distributed at the epitope sites.
The study demonstrated that a major antigenic drift had occurred in the viruses isolated in central China. And monitoring the antigenic property should be the priority in preventing the potential pandemic of H5N1 avian influenza virus.
Url:
DOI: 10.1186/1743-422X-9-148
PubMed: 22866955
PubMed Central: 3490895
Affiliations:
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R, 430070, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Agriculture Microbiology, Huazhong Agriculture University, Wuhan, P. R, 430070</wicri:regionArea><wicri:noRegion>430070</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Jiping" sort="Zhu, Jiping" uniqKey="Zhu J" first="Jiping" last="Zhu">Jiping Zhu</name><affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Agriculture Microbiology, Huazhong Agriculture University, Wuhan, P. R, 430070, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Agriculture Microbiology, Huazhong Agriculture University, Wuhan, P. 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R, 430070, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Agriculture Microbiology, Huazhong Agriculture University, Wuhan, P. R, 430070</wicri:regionArea><wicri:noRegion>430070</wicri:noRegion></affiliation></author><author><name sortKey="Ke, Jianjiang" sort="Ke, Jianjiang" uniqKey="Ke J" first="Jianjiang" last="Ke">Jianjiang Ke</name><affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Agriculture Microbiology, Huazhong Agriculture University, Wuhan, P. R, 430070, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Agriculture Microbiology, Huazhong Agriculture University, Wuhan, P. R, 430070</wicri:regionArea><wicri:noRegion>430070</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Jiping" sort="Zhu, Jiping" uniqKey="Zhu J" first="Jiping" last="Zhu">Jiping Zhu</name><affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Agriculture Microbiology, Huazhong Agriculture University, Wuhan, P. R, 430070, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Agriculture Microbiology, Huazhong Agriculture University, Wuhan, P. R, 430070</wicri:regionArea><wicri:noRegion>430070</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Hongbo" sort="Zhou, Hongbo" uniqKey="Zhou H" first="Hongbo" last="Zhou">Hongbo Zhou</name><affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Agriculture Microbiology, Huazhong Agriculture University, Wuhan, P. R, 430070, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Agriculture Microbiology, Huazhong Agriculture University, Wuhan, P. R, 430070</wicri:regionArea><wicri:noRegion>430070</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agriculture University, Wuhan, P. R., 430070, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agriculture University, Wuhan, P. R., 430070</wicri:regionArea><wicri:noRegion>430070</wicri:noRegion></affiliation></author><author><name sortKey="Jin, Meilin" sort="Jin, Meilin" uniqKey="Jin M" first="Meilin" last="Jin">Meilin Jin</name><affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Agriculture Microbiology, Huazhong Agriculture University, Wuhan, P. R, 430070, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Agriculture Microbiology, Huazhong Agriculture University, Wuhan, P. R, 430070</wicri:regionArea><wicri:noRegion>430070</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agriculture University, Wuhan, P. R., 430070, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agriculture University, Wuhan, P. R., 430070</wicri:regionArea><wicri:noRegion>430070</wicri:noRegion></affiliation></author></analytic><series><title level="j">Virology Journal</title><idno type="eISSN">1743-422X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Three influenza pandemics outbroke in the last century accompanied the viral antigen shift and drift, resulting in the change of antigenic property and the low cross protective ability of the existed antibody to the newly emerged pandemic virus, and eventually the death of millions of people. The antigenic characterizations of the viruses isolated in central China in 2004 and 2006–2007 were investigated in the present study.</p></sec><sec><title>Results</title><p>Hemagglutinin inhibition assay and neutralization assay displayed differential antigenic characteristics of the viruses isolated in central China in two periods (2004 and 2006–2007). HA genes of the viruses mainly located in two branches in phylogeny analysis. 53 mutations of the deduced amino acids of the HA genes were divided into 4 patterns. Mutations in pattern 2 and 3 showed the main difference between viruses isolated in 2004 and 2006–2007. Meanwhile, most amino acids in pattern 2 and 3 located in the globular head of the HA protein, and some of the mutations evenly distributed at the epitope sites.</p></sec><sec><title>Conclusions</title><p>The study demonstrated that a major antigenic drift had occurred in the viruses isolated in central China. 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sortKey="Rudneva, Ia" uniqKey="Rudneva I">IA Rudneva</name></author><author><name sortKey="Govorkova, Ea" uniqKey="Govorkova E">EA Govorkova</name></author><author><name sortKey="Timofeeva, Ta" uniqKey="Timofeeva T">TA Timofeeva</name></author><author><name sortKey="Shilov, Aa" uniqKey="Shilov A">AA Shilov</name></author><author><name sortKey="Kochergin Nikitsky, Ks" uniqKey="Kochergin Nikitsky K">KS Kochergin-Nikitsky</name></author><author><name sortKey="Krylov, Ps" uniqKey="Krylov P">PS Krylov</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rudneva, Ia" uniqKey="Rudneva I">IA Rudneva</name></author><author><name sortKey="Kushch, Aa" uniqKey="Kushch A">AA Kushch</name></author><author><name sortKey="Masalova, Ov" uniqKey="Masalova O">OV Masalova</name></author><author><name sortKey="Timofeeva, Ta" uniqKey="Timofeeva T">TA Timofeeva</name></author><author><name sortKey="Klimova, Rr" uniqKey="Klimova R">RR Klimova</name></author><author><name sortKey="Shilov, Aa" uniqKey="Shilov A">AA Shilov</name></author><author><name sortKey="Ignatieva, Av" uniqKey="Ignatieva A">AV Ignatieva</name></author><author><name sortKey="Krylov, Ps" uniqKey="Krylov P">PS Krylov</name></author><author><name sortKey="Kaverin, Nv" uniqKey="Kaverin N">NV Kaverin</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zou, Wei" sort="Zou, Wei" uniqKey="Zou W" first="Wei" last="Zou">Wei Zou</name></noRegion><name sortKey="Jin, Meilin" sort="Jin, Meilin" uniqKey="Jin M" first="Meilin" last="Jin">Meilin Jin</name><name sortKey="Jin, Meilin" sort="Jin, Meilin" uniqKey="Jin M" first="Meilin" last="Jin">Meilin Jin</name><name sortKey="Ke, Jianjiang" sort="Ke, Jianjiang" uniqKey="Ke J" first="Jianjiang" last="Ke">Jianjiang Ke</name><name sortKey="Zhou, Hongbo" sort="Zhou, Hongbo" uniqKey="Zhou H" first="Hongbo" last="Zhou">Hongbo Zhou</name><name sortKey="Zhou, Hongbo" sort="Zhou, Hongbo" uniqKey="Zhou H" first="Hongbo" last="Zhou">Hongbo Zhou</name><name sortKey="Zhu, Jiping" sort="Zhu, Jiping" uniqKey="Zhu J" first="Jiping" last="Zhu">Jiping Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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