Adaptation of novel H7N9 influenza A virus to human receptors
Identifieur interne : 000919 ( Main/Exploration ); précédent : 000918; suivant : 000920Adaptation of novel H7N9 influenza A virus to human receptors
Auteurs : J. C. F. M. Dortmans [Pays-Bas] ; J. Dekkers [Pays-Bas] ; I. N. Ambepitiya Wickramasinghe [Pays-Bas] ; M. H. Verheije [Pays-Bas] ; P. J. M. Rottier [Pays-Bas] ; F. J. M. Van Kuppeveld [Pays-Bas] ; E. De Vries [Pays-Bas] ; C. A. M. De Haan [Pays-Bas]Source :
- Scientific Reports [ 2045-2322 ] ; 2013.
Abstract
The emergence of the novel H7N9 influenza A virus (IAV) has caused global concerns about the ability of this virus to spread between humans. Analysis of the receptor-binding properties of this virus using a recombinant protein approach in combination with fetuin-binding, glycan array and human tissue-binding assays demonstrates increased binding of H7 to both α2-6 and α2-8 sialosides as well as reduced binding to α2-3-linked SIAs compared to a closely related avian H7N9 virus from 2008. These differences could be attributed to substitutions Q226L and G186V. Analysis of the enzymatic activity of the neuraminidase N9 protein indicated a reduced sialidase activity, consistent with the reduced binding of H7 to α2-3 sialosides. However, the novel H7N9 virus still preferred binding to α2-3- over α2-6-linked SIAs and was not able to efficiently bind to epithelial cells of human trachea in contrast to seasonal IAV, consistent with its limited human-to-human transmission.
Url:
DOI: 10.1038/srep03058
PubMed: 24162312
PubMed Central: 3808826
Affiliations:
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Le document en format XML
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C. F. M." last="Dortmans">J. C. F. M. Dortmans</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University</institution>, 3584 CL Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>, 3584 CL Utrecht</wicri:regionArea><wicri:noRegion>3584 CL Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Dekkers, J" sort="Dekkers, J" uniqKey="Dekkers J" first="J." last="Dekkers">J. 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Rottier</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University</institution>, 3584 CL Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>, 3584 CL Utrecht</wicri:regionArea><wicri:noRegion>3584 CL Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Van Kuppeveld, F J M" sort="Van Kuppeveld, F J M" uniqKey="Van Kuppeveld F" first="F. J. M." last="Van Kuppeveld">F. J. M. 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De Vries</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University</institution>, 3584 CL Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>, 3584 CL Utrecht</wicri:regionArea><wicri:noRegion>3584 CL Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="De Haan, C A M" sort="De Haan, C A M" uniqKey="De Haan C" first="C. A. M." last="De Haan">C. A. M. De Haan</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University</institution>, 3584 CL Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>, 3584 CL Utrecht</wicri:regionArea><wicri:noRegion>3584 CL Utrecht</wicri:noRegion></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The emergence of the novel H7N9 influenza A virus (IAV) has caused global concerns about the ability of this virus to spread between humans. Analysis of the receptor-binding properties of this virus using a recombinant protein approach in combination with fetuin-binding, glycan array and human tissue-binding assays demonstrates increased binding of H7 to both α2-6 and α2-8 sialosides as well as reduced binding to α2-3-linked SIAs compared to a closely related avian H7N9 virus from 2008. These differences could be attributed to substitutions Q226L and G186V. Analysis of the enzymatic activity of the neuraminidase N9 protein indicated a reduced sialidase activity, consistent with the reduced binding of H7 to α2-3 sialosides. However, the novel H7N9 virus still preferred binding to α2-3- over α2-6-linked SIAs and was not able to efficiently bind to epithelial cells of human trachea in contrast to seasonal IAV, consistent with its limited human-to-human transmission.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gao, R" uniqKey="Gao R">R. 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Cornelissen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Dortmans, J C F M" sort="Dortmans, J C F M" uniqKey="Dortmans J" first="J. C. F. M." last="Dortmans">J. C. F. M. Dortmans</name></noRegion><name sortKey="De Haan, C A M" sort="De Haan, C A M" uniqKey="De Haan C" first="C. A. M." last="De Haan">C. A. M. De Haan</name><name sortKey="De Vries, E" sort="De Vries, E" uniqKey="De Vries E" first="E." last="De Vries">E. De Vries</name><name sortKey="Dekkers, J" sort="Dekkers, J" uniqKey="Dekkers J" first="J." last="Dekkers">J. Dekkers</name><name sortKey="Rottier, P J M" sort="Rottier, P J M" uniqKey="Rottier P" first="P. J. M." last="Rottier">P. J. M. Rottier</name><name sortKey="Van Kuppeveld, F J M" sort="Van Kuppeveld, F J M" uniqKey="Van Kuppeveld F" first="F. J. M." last="Van Kuppeveld">F. J. M. Van Kuppeveld</name><name sortKey="Verheije, M H" sort="Verheije, M H" uniqKey="Verheije M" first="M. H." last="Verheije">M. H. Verheije</name><name sortKey="Wickramasinghe, I N Ambepitiya" sort="Wickramasinghe, I N Ambepitiya" uniqKey="Wickramasinghe I" first="I. N. Ambepitiya" last="Wickramasinghe">I. N. Ambepitiya Wickramasinghe</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24162312" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |