Evidence of Cross-Reactive Immunity to 2009 Pandemic Influenza A Virus in Workers Seropositive to Swine H1N1 Influenza Viruses Circulating in Italy
Identifieur interne : 000892 ( Main/Exploration ); précédent : 000891; suivant : 000893Evidence of Cross-Reactive Immunity to 2009 Pandemic Influenza A Virus in Workers Seropositive to Swine H1N1 Influenza Viruses Circulating in Italy
Auteurs : Maria A. De Marco [Italie] ; Stefano Porru [Italie] ; Paolo Cordioli [Italie] ; Bruno M. Cesana [Italie] ; Ana Moreno [Italie] ; Laura Calzoletti [Italie] ; Lebana Bonfanti [Italie] ; Arianna Boni [Italie] ; Antonio Scotto Di Carlo [Italie] ; Cecilia Arici [Italie] ; Angela Carta [Italie] ; Maria R. Castrucci [Italie] ; Isabella Donatelli [Italie] ; Paola Tomao [Italie] ; Vittoria M. Peri [Italie] ; Livia Di Trani [Italie] ; Nicoletta Vonesch [Italie]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
Pigs play a key epidemiologic role in the ecology of influenza A viruses (IAVs) emerging from animal hosts and transmitted to humans. Between 2008 and 2010, we investigated the health risk of occupational exposure to swine influenza viruses (SIVs) in Italy, during the emergence and spread of the 2009 H1N1 pandemic (H1N1pdm) virus.
Serum samples from 123 swine workers (SWs) and 379 control subjects (Cs), not exposed to pig herds, were tested by haemagglutination inhibition (HI) assay against selected SIVs belonging to H1N1 (swH1N1), H1N2 (swH1N2) and H3N2 (swH3N2) subtypes circulating in the study area. Potential cross-reactivity between swine and human IAVs was evaluated by testing sera against recent, pandemic and seasonal, human influenza viruses (H1N1 and H3N2 antigenic subtypes). Samples tested against swH1N1 and H1N1pdm viruses were categorized into sera collected before (n. 84 SWs; n. 234 Cs) and after (n. 39 SWs; n. 145 Cs) the pandemic peak. HI-antibody titers ≥10 were considered positive. In both pre-pandemic and post-pandemic peak subperiods, SWs showed significantly higher swH1N1 seroprevalences when compared with Cs (52.4% vs. 4.7% and 59% vs. 9.7%, respectively). Comparable HI results were obtained against H1N1pdm antigen (58.3% vs. 7.7% and 59% vs. 31.7%, respectively). No differences were found between HI seroreactivity detected in SWs and Cs against swH1N2 (33.3% vs. 40.4%) and swH3N2 (51.2 vs. 55.4%) viruses. These findings indicate the occurrence of swH1N1 transmission from pigs to Italian SWs.
A significant increase of H1N1pdm seroprevalences occurred in the post-pandemic peak subperiod in the Cs (p<0.001) whereas SWs showed no differences between the two subperiods, suggesting a possible occurrence of cross-protective immunity related to previous swH1N1 infections. These data underline the importance of risk assessment and occupational health surveillance activities aimed at early detection and control of SIVs with pandemic potential in humans.
Url:
DOI: 10.1371/journal.pone.0057576
PubMed: 23469029
PubMed Central: 3585202
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000B57
- to stream Pmc, to step Curation: 000B57
- to stream Pmc, to step Checkpoint: 000626
- to stream Ncbi, to step Merge: 000884
- to stream Ncbi, to step Curation: 000884
- to stream Ncbi, to step Checkpoint: 000884
- to stream Main, to step Merge: 000893
- to stream Main, to step Curation: 000892
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evidence of Cross-Reactive Immunity to 2009 Pandemic Influenza A Virus in Workers Seropositive to Swine H1N1 Influenza Viruses Circulating in Italy</title><author><name sortKey="De Marco, Maria A" sort="De Marco, Maria A" uniqKey="De Marco M" first="Maria A." last="De Marco">Maria A. De Marco</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute for Environmental Protection and Research (ISPRA), Ozzano Emilia, Bologna, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Environmental Protection and Research (ISPRA), Ozzano Emilia, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Porru, Stefano" sort="Porru, Stefano" uniqKey="Porru S" first="Stefano" last="Porru">Stefano Porru</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Experimental and Applied Medicine, University of Brescia, Brescia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Applied Medicine, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Cordioli, Paolo" sort="Cordioli, Paolo" uniqKey="Cordioli P" first="Paolo" last="Cordioli">Paolo Cordioli</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, Brescia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Cesana, Bruno M" sort="Cesana, Bruno M" uniqKey="Cesana B" first="Bruno M." last="Cesana">Bruno M. Cesana</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Department of Biomedical Sciences and Biotechnologies, University of Brescia, Brescia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedical Sciences and Biotechnologies, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Moreno, Ana" sort="Moreno, Ana" uniqKey="Moreno A" first="Ana" last="Moreno">Ana Moreno</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, Brescia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Calzoletti, Laura" sort="Calzoletti, Laura" uniqKey="Calzoletti L" first="Laura" last="Calzoletti">Laura Calzoletti</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Bonfanti, Lebana" sort="Bonfanti, Lebana" uniqKey="Bonfanti L" first="Lebana" last="Bonfanti">Lebana Bonfanti</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padua, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Boni, Arianna" sort="Boni, Arianna" uniqKey="Boni A" first="Arianna" last="Boni">Arianna Boni</name><affiliation wicri:level="3"><nlm:aff id="aff7"><addr-line>Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Rome, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Di Carlo, Antonio Scotto" sort="Di Carlo, Antonio Scotto" uniqKey="Di Carlo A" first="Antonio Scotto" last="Di Carlo">Antonio Scotto Di Carlo</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Experimental and Applied Medicine, University of Brescia, Brescia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Applied Medicine, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Arici, Cecilia" sort="Arici, Cecilia" uniqKey="Arici C" first="Cecilia" last="Arici">Cecilia Arici</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Experimental and Applied Medicine, University of Brescia, Brescia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Applied Medicine, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Carta, Angela" sort="Carta, Angela" uniqKey="Carta A" first="Angela" last="Carta">Angela Carta</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Experimental and Applied Medicine, University of Brescia, Brescia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Applied Medicine, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Castrucci, Maria R" sort="Castrucci, Maria R" uniqKey="Castrucci M" first="Maria R." last="Castrucci">Maria R. Castrucci</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Donatelli, Isabella" sort="Donatelli, Isabella" uniqKey="Donatelli I" first="Isabella" last="Donatelli">Isabella Donatelli</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Tomao, Paola" sort="Tomao, Paola" uniqKey="Tomao P" first="Paola" last="Tomao">Paola Tomao</name><affiliation wicri:level="3"><nlm:aff id="aff8"><addr-line>Department of Occupational Medicine, Italian Workers' Compensation Authority-Research Area (INAIL), Monteporzio Catone, Rome, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Occupational Medicine, Italian Workers' Compensation Authority-Research Area (INAIL), Monteporzio Catone, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Peri, Vittoria M" sort="Peri, Vittoria M" uniqKey="Peri V" first="Vittoria M." last="Peri">Vittoria M. Peri</name><affiliation wicri:level="3"><nlm:aff id="aff8"><addr-line>Department of Occupational Medicine, Italian Workers' Compensation Authority-Research Area (INAIL), Monteporzio Catone, Rome, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Occupational Medicine, Italian Workers' Compensation Authority-Research Area (INAIL), Monteporzio Catone, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Di Trani, Livia" sort="Di Trani, Livia" uniqKey="Di Trani L" first="Livia" last="Di Trani">Livia Di Trani</name><affiliation wicri:level="3"><nlm:aff id="aff7"><addr-line>Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Rome, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Vonesch, Nicoletta" sort="Vonesch, Nicoletta" uniqKey="Vonesch N" first="Nicoletta" last="Vonesch">Nicoletta Vonesch</name><affiliation wicri:level="3"><nlm:aff id="aff8"><addr-line>Department of Occupational Medicine, Italian Workers' Compensation Authority-Research Area (INAIL), Monteporzio Catone, Rome, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Occupational Medicine, Italian Workers' Compensation Authority-Research Area (INAIL), Monteporzio Catone, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23469029</idno><idno type="pmc">3585202</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585202</idno><idno type="RBID">PMC:3585202</idno><idno type="doi">10.1371/journal.pone.0057576</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000B57</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B57</idno><idno type="wicri:Area/Pmc/Curation">000B57</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B57</idno><idno type="wicri:Area/Pmc/Checkpoint">000626</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000626</idno><idno type="wicri:Area/Ncbi/Merge">000884</idno><idno type="wicri:Area/Ncbi/Curation">000884</idno><idno type="wicri:Area/Ncbi/Checkpoint">000884</idno><idno type="wicri:Area/Main/Merge">000893</idno><idno type="wicri:Area/Main/Curation">000892</idno><idno type="wicri:Area/Main/Exploration">000892</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evidence of Cross-Reactive Immunity to 2009 Pandemic Influenza A Virus in Workers Seropositive to Swine H1N1 Influenza Viruses Circulating in Italy</title><author><name sortKey="De Marco, Maria A" sort="De Marco, Maria A" uniqKey="De Marco M" first="Maria A." last="De Marco">Maria A. De Marco</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute for Environmental Protection and Research (ISPRA), Ozzano Emilia, Bologna, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Environmental Protection and Research (ISPRA), Ozzano Emilia, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Porru, Stefano" sort="Porru, Stefano" uniqKey="Porru S" first="Stefano" last="Porru">Stefano Porru</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Experimental and Applied Medicine, University of Brescia, Brescia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Applied Medicine, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Cordioli, Paolo" sort="Cordioli, Paolo" uniqKey="Cordioli P" first="Paolo" last="Cordioli">Paolo Cordioli</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, Brescia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Cesana, Bruno M" sort="Cesana, Bruno M" uniqKey="Cesana B" first="Bruno M." last="Cesana">Bruno M. Cesana</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Department of Biomedical Sciences and Biotechnologies, University of Brescia, Brescia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedical Sciences and Biotechnologies, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Moreno, Ana" sort="Moreno, Ana" uniqKey="Moreno A" first="Ana" last="Moreno">Ana Moreno</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, Brescia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Calzoletti, Laura" sort="Calzoletti, Laura" uniqKey="Calzoletti L" first="Laura" last="Calzoletti">Laura Calzoletti</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Bonfanti, Lebana" sort="Bonfanti, Lebana" uniqKey="Bonfanti L" first="Lebana" last="Bonfanti">Lebana Bonfanti</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padua, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Boni, Arianna" sort="Boni, Arianna" uniqKey="Boni A" first="Arianna" last="Boni">Arianna Boni</name><affiliation wicri:level="3"><nlm:aff id="aff7"><addr-line>Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Rome, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Di Carlo, Antonio Scotto" sort="Di Carlo, Antonio Scotto" uniqKey="Di Carlo A" first="Antonio Scotto" last="Di Carlo">Antonio Scotto Di Carlo</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Experimental and Applied Medicine, University of Brescia, Brescia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Applied Medicine, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Arici, Cecilia" sort="Arici, Cecilia" uniqKey="Arici C" first="Cecilia" last="Arici">Cecilia Arici</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Experimental and Applied Medicine, University of Brescia, Brescia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Applied Medicine, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Carta, Angela" sort="Carta, Angela" uniqKey="Carta A" first="Angela" last="Carta">Angela Carta</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Experimental and Applied Medicine, University of Brescia, Brescia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Applied Medicine, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Castrucci, Maria R" sort="Castrucci, Maria R" uniqKey="Castrucci M" first="Maria R." last="Castrucci">Maria R. Castrucci</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Donatelli, Isabella" sort="Donatelli, Isabella" uniqKey="Donatelli I" first="Isabella" last="Donatelli">Isabella Donatelli</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Tomao, Paola" sort="Tomao, Paola" uniqKey="Tomao P" first="Paola" last="Tomao">Paola Tomao</name><affiliation wicri:level="3"><nlm:aff id="aff8"><addr-line>Department of Occupational Medicine, Italian Workers' Compensation Authority-Research Area (INAIL), Monteporzio Catone, Rome, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Occupational Medicine, Italian Workers' Compensation Authority-Research Area (INAIL), Monteporzio Catone, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Peri, Vittoria M" sort="Peri, Vittoria M" uniqKey="Peri V" first="Vittoria M." last="Peri">Vittoria M. Peri</name><affiliation wicri:level="3"><nlm:aff id="aff8"><addr-line>Department of Occupational Medicine, Italian Workers' Compensation Authority-Research Area (INAIL), Monteporzio Catone, Rome, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Occupational Medicine, Italian Workers' Compensation Authority-Research Area (INAIL), Monteporzio Catone, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Di Trani, Livia" sort="Di Trani, Livia" uniqKey="Di Trani L" first="Livia" last="Di Trani">Livia Di Trani</name><affiliation wicri:level="3"><nlm:aff id="aff7"><addr-line>Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Rome, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Vonesch, Nicoletta" sort="Vonesch, Nicoletta" uniqKey="Vonesch N" first="Nicoletta" last="Vonesch">Nicoletta Vonesch</name><affiliation wicri:level="3"><nlm:aff id="aff8"><addr-line>Department of Occupational Medicine, Italian Workers' Compensation Authority-Research Area (INAIL), Monteporzio Catone, Rome, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Occupational Medicine, Italian Workers' Compensation Authority-Research Area (INAIL), Monteporzio Catone, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Pigs play a key epidemiologic role in the ecology of influenza A viruses (IAVs) emerging from animal hosts and transmitted to humans. Between 2008 and 2010, we investigated the health risk of occupational exposure to swine influenza viruses (SIVs) in Italy, during the emergence and spread of the 2009 H1N1 pandemic (H1N1pdm) virus.</p></sec><sec><title>Methodology/Principal Findings</title><p>Serum samples from 123 swine workers (SWs) and 379 control subjects (Cs), not exposed to pig herds, were tested by haemagglutination inhibition (HI) assay against selected SIVs belonging to H1N1 (swH1N1), H1N2 (swH1N2) and H3N2 (swH3N2) subtypes circulating in the study area. Potential cross-reactivity between swine and human IAVs was evaluated by testing sera against recent, pandemic and seasonal, human influenza viruses (H1N1 and H3N2 antigenic subtypes). Samples tested against swH1N1 and H1N1pdm viruses were categorized into sera collected before (n. 84 SWs; n. 234 Cs) and after (n. 39 SWs; n. 145 Cs) the pandemic peak. HI-antibody titers ≥10 were considered positive. In both pre-pandemic and post-pandemic peak subperiods, SWs showed significantly higher swH1N1 seroprevalences when compared with Cs (52.4% vs. 4.7% and 59% vs. 9.7%, respectively). Comparable HI results were obtained against H1N1pdm antigen (58.3% vs. 7.7% and 59% vs. 31.7%, respectively). No differences were found between HI seroreactivity detected in SWs and Cs against swH1N2 (33.3% vs. 40.4%) and swH3N2 (51.2 vs. 55.4%) viruses. These findings indicate the occurrence of swH1N1 transmission from pigs to Italian SWs.</p></sec><sec><title>Conclusion/Significance</title><p>A significant increase of H1N1pdm seroprevalences occurred in the post-pandemic peak subperiod in the Cs (p<0.001) whereas SWs showed no differences between the two subperiods, suggesting a possible occurrence of cross-protective immunity related to previous swH1N1 infections. These data underline the importance of risk assessment and occupational health surveillance activities aimed at early detection and control of SIVs with pandemic potential in humans.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Neumann, G" uniqKey="Neumann G">G Neumann</name></author><author><name sortKey="Noda, T" uniqKey="Noda T">T Noda</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Bean, Wj" uniqKey="Bean W">WJ Bean</name></author><author><name sortKey="Gorman, Ot" uniqKey="Gorman O">OT Gorman</name></author><author><name sortKey="Chambers, Tm" uniqKey="Chambers T">TM Chambers</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nichol, St" uniqKey="Nichol S">ST Nichol</name></author><author><name sortKey="Arikawa, J" uniqKey="Arikawa J">J Arikawa</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moreno, A" uniqKey="Moreno A">A Moreno</name></author><author><name sortKey="Di Trani, L" uniqKey="Di Trani L">L Di Trani</name></author><author><name sortKey="Faccini, S" uniqKey="Faccini S">S Faccini</name></author><author><name sortKey="Vaccari, G" uniqKey="Vaccari G">G Vaccari</name></author><author><name sortKey="Nigrelli, D" uniqKey="Nigrelli D">D Nigrelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kyriakis, Cs" uniqKey="Kyriakis C">CS Kyriakis</name></author><author><name sortKey="Brown, Ih" uniqKey="Brown I">IH Brown</name></author><author><name sortKey="Foni, E" uniqKey="Foni E">E Foni</name></author><author><name sortKey="Kuntz Simon, G" uniqKey="Kuntz Simon G">G Kuntz-Simon</name></author><author><name sortKey="Maldonado, J" uniqKey="Maldonado J">J Maldonado</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moreno, A" uniqKey="Moreno A">A Moreno</name></author><author><name sortKey="Chiapponi, C" uniqKey="Chiapponi C">C Chiapponi</name></author><author><name sortKey="Boniotti, Mb" uniqKey="Boniotti M">MB Boniotti</name></author><author><name sortKey="Sozzi, E" uniqKey="Sozzi E">E Sozzi</name></author><author><name sortKey="Foni, E" uniqKey="Foni E">E Foni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pensaert, M" uniqKey="Pensaert M">M Pensaert</name></author><author><name sortKey="Ottis, K" uniqKey="Ottis K">K Ottis</name></author><author><name sortKey="Vandeputte, J" uniqKey="Vandeputte J">J Vandeputte</name></author><author><name sortKey="Kaplan, Mm" uniqKey="Kaplan M">MM Kaplan</name></author><author><name sortKey="Bachmann, Pa" uniqKey="Bachmann P">PA Bachmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Castrucci, Mr" uniqKey="Castrucci M">MR Castrucci</name></author><author><name sortKey="Donatelli, I" uniqKey="Donatelli I">I Donatelli</name></author><author><name sortKey="Sidoli, L" uniqKey="Sidoli L">L Sidoli</name></author><author><name sortKey="Barigazzi, G" uniqKey="Barigazzi G">G Barigazzi</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, Ih" uniqKey="Brown I">IH Brown</name></author><author><name sortKey="Harris, Pa" uniqKey="Harris P">PA Harris</name></author><author><name sortKey="Mccauley, Jw" uniqKey="Mccauley J">JW McCauley</name></author><author><name sortKey="Alexander, Dj" uniqKey="Alexander D">DJ Alexander</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Myers, Kp" uniqKey="Myers K">KP Myers</name></author><author><name sortKey="Olsen, Cw" uniqKey="Olsen C">CW Olsen</name></author><author><name sortKey="Gray, Gc" uniqKey="Gray G">GC Gray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olsen, Cw" uniqKey="Olsen C">CW Olsen</name></author><author><name sortKey="Brammer, L" uniqKey="Brammer L">L Brammer</name></author><author><name sortKey="Easterday, Bc" uniqKey="Easterday B">BC Easterday</name></author><author><name sortKey="Arden, N" uniqKey="Arden N">N Arden</name></author><author><name sortKey="Belay, E" uniqKey="Belay E">E Belay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ayora Talavera, G" uniqKey="Ayora Talavera G">G Ayora-Talavera</name></author><author><name sortKey="Cadavieco Burgos, Jm" uniqKey="Cadavieco Burgos J">JM Cadavieco-Burgos</name></author><author><name sortKey="Canul Armas, Ab" uniqKey="Canul Armas A">AB Canul-Armas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Myers, Kp" uniqKey="Myers K">KP Myers</name></author><author><name sortKey="Olsen, Cw" uniqKey="Olsen C">CW Olsen</name></author><author><name sortKey="Setterquist, Sf" uniqKey="Setterquist S">SF Setterquist</name></author><author><name sortKey="Capuano, Aw" uniqKey="Capuano A">AW Capuano</name></author><author><name sortKey="Donham, Kj" uniqKey="Donham K">KJ Donham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramirez, A" uniqKey="Ramirez A">A Ramirez</name></author><author><name sortKey="Capuano, Aw" uniqKey="Capuano A">AW Capuano</name></author><author><name sortKey="Wellman, Da" uniqKey="Wellman D">DA Wellman</name></author><author><name sortKey="Lesher, Ka" uniqKey="Lesher K">KA Lesher</name></author><author><name sortKey="Setterquist, Sf" uniqKey="Setterquist S">SF Setterquist</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gray, Gc" uniqKey="Gray G">GC Gray</name></author><author><name sortKey="Mccarthy, T" uniqKey="Mccarthy T">T McCarthy</name></author><author><name sortKey="Capuano, Aw" uniqKey="Capuano A">AW Capuano</name></author><author><name sortKey="Setterquist, Sf" uniqKey="Setterquist S">SF Setterquist</name></author><author><name sortKey="Olsen, Cw" uniqKey="Olsen C">CW Olsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Terebuh, P" uniqKey="Terebuh P">P Terebuh</name></author><author><name sortKey="Olsen, Cw" uniqKey="Olsen C">CW Olsen</name></author><author><name sortKey="Wright, J" uniqKey="Wright J">J Wright</name></author><author><name sortKey="Klimov, A" uniqKey="Klimov A">A Klimov</name></author><author><name sortKey="Karasin, A" uniqKey="Karasin A">A Karasin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="L Pez Robles, G" uniqKey="L Pez Robles G">G López-Robles</name></author><author><name sortKey="Montalvo Corral, M" uniqKey="Montalvo Corral M">M Montalvo-Corral</name></author><author><name sortKey="Caire Juvera, G" uniqKey="Caire Juvera G">G Caire-Juvera</name></author><author><name sortKey="Ayora Talavera, G" uniqKey="Ayora Talavera G">G Ayora-Talavera</name></author><author><name sortKey="Hernandez, J" uniqKey="Hernandez J">J Hernández</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Campitelli, L" uniqKey="Campitelli L">L Campitelli</name></author><author><name sortKey="Donatelli, I" uniqKey="Donatelli I">I Donatelli</name></author><author><name sortKey="Foni, E" uniqKey="Foni E">E Foni</name></author><author><name sortKey="Castrucci, Mr" uniqKey="Castrucci M">MR Castrucci</name></author><author><name sortKey="Fabiani, C" uniqKey="Fabiani C">C Fabiani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerloff, Na" uniqKey="Gerloff N">NA Gerloff</name></author><author><name sortKey="Kremer, Jr" uniqKey="Kremer J">JR Kremer</name></author><author><name sortKey="Charpentier, E" uniqKey="Charpentier E">E Charpentier</name></author><author><name sortKey="Sausy, A" uniqKey="Sausy A">A Sausy</name></author><author><name sortKey="Olinger, Cm" uniqKey="Olinger C">CM Olinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krumbholz, A" uniqKey="Krumbholz A">A Krumbholz</name></author><author><name sortKey="Lange, J" uniqKey="Lange J">J Lange</name></author><author><name sortKey="Durrwald, R" uniqKey="Durrwald R">R Dürrwald</name></author><author><name sortKey="Hoyer, H" uniqKey="Hoyer H">H Hoyer</name></author><author><name sortKey="Bengsch, S" uniqKey="Bengsch S">S Bengsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kitikoon, P" uniqKey="Kitikoon P">P Kitikoon</name></author><author><name sortKey="Sreta, D" uniqKey="Sreta D">D Sreta</name></author><author><name sortKey="Tuanudom, R" uniqKey="Tuanudom R">R Tuanudom</name></author><author><name sortKey="Amonsin, A" uniqKey="Amonsin A">A Amonsin</name></author><author><name sortKey="Suradhat, S" uniqKey="Suradhat S">S Suradhat</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Medina, Ra" uniqKey="Medina R">RA Medina</name></author><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A García-Sastre</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Maiorano, G" uniqKey="Maiorano G">G Maiorano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kyriakis, Cs" uniqKey="Kyriakis C">CS Kyriakis</name></author><author><name sortKey="Olsen, Cw" uniqKey="Olsen C">CW Olsen</name></author><author><name sortKey="Carman, S" uniqKey="Carman S">S Carman</name></author><author><name sortKey="Brown, Ih" uniqKey="Brown I">IH Brown</name></author><author><name sortKey="Brookes, Sm" uniqKey="Brookes S">SM Brookes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, E" uniqKey="Miller E">E Miller</name></author><author><name sortKey="Hoschler, K" uniqKey="Hoschler K">K Hoschler</name></author><author><name sortKey="Hardelid, P" uniqKey="Hardelid P">P Hardelid</name></author><author><name sortKey="Stanford, E" uniqKey="Stanford E">E Stanford</name></author><author><name sortKey="Andrews, N" uniqKey="Andrews N">N Andrews</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Dudareva, S" uniqKey="Dudareva S">S Dudareva</name></author><author><name sortKey="Schweiger, B" uniqKey="Schweiger B">B Schweiger</name></author><author><name sortKey="Thamm, M" uniqKey="Thamm M">M Thamm</name></author><author><name sortKey="Hohle, M" uniqKey="Hohle M">M Höhle</name></author><author><name sortKey="Stark, K" uniqKey="Stark K">K Stark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gray, Gc" uniqKey="Gray G">GC Gray</name></author><author><name sortKey="Baker, Ws" uniqKey="Baker W">WS Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gray, Gc" uniqKey="Gray G">GC Gray</name></author><author><name sortKey="Trampel, Dw" uniqKey="Trampel D">DW Trampel</name></author><author><name sortKey="Roth, Ja" uniqKey="Roth J">JA Roth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perera, Ra" uniqKey="Perera R">RA Perera</name></author><author><name sortKey="Riley, S" uniqKey="Riley S">S Riley</name></author><author><name sortKey="Ma, Sk" uniqKey="Ma S">SK Ma</name></author><author><name sortKey="Zhu, Hc" uniqKey="Zhu H">HC Zhu</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vincent, Al" uniqKey="Vincent A">AL Vincent</name></author><author><name sortKey="Lager, Km" uniqKey="Lager K">KM Lager</name></author><author><name sortKey="Faaberg, Ks" uniqKey="Faaberg K">KS Faaberg</name></author><author><name sortKey="Harland, M" uniqKey="Harland M">M Harland</name></author><author><name sortKey="Zanella, El" uniqKey="Zanella E">EL Zanella</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kash, Jc" uniqKey="Kash J">JC Kash</name></author><author><name sortKey="Qi, L" uniqKey="Qi L">L Qi</name></author><author><name sortKey="Dugan, Vg" uniqKey="Dugan V">VG Dugan</name></author><author><name sortKey="Jagger, Bw" uniqKey="Jagger B">BW Jagger</name></author><author><name sortKey="Hrabal, Rj" uniqKey="Hrabal R">RJ Hrabal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, Pg" uniqKey="Thomas P">PG Thomas</name></author><author><name sortKey="Keating, R" uniqKey="Keating R">R Keating</name></author><author><name sortKey="Hulse Post, Dj" uniqKey="Hulse Post D">DJ Hulse-Post</name></author><author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><region name="Latium"><name sortKey="De Marco, Maria A" sort="De Marco, Maria A" uniqKey="De Marco M" first="Maria A." last="De Marco">Maria A. De Marco</name></region><name sortKey="Arici, Cecilia" sort="Arici, Cecilia" uniqKey="Arici C" first="Cecilia" last="Arici">Cecilia Arici</name><name sortKey="Bonfanti, Lebana" sort="Bonfanti, Lebana" uniqKey="Bonfanti L" first="Lebana" last="Bonfanti">Lebana Bonfanti</name><name sortKey="Boni, Arianna" sort="Boni, Arianna" uniqKey="Boni A" first="Arianna" last="Boni">Arianna Boni</name><name sortKey="Calzoletti, Laura" sort="Calzoletti, Laura" uniqKey="Calzoletti L" first="Laura" last="Calzoletti">Laura Calzoletti</name><name sortKey="Carta, Angela" sort="Carta, Angela" uniqKey="Carta A" first="Angela" last="Carta">Angela Carta</name><name sortKey="Castrucci, Maria R" sort="Castrucci, Maria R" uniqKey="Castrucci M" first="Maria R." last="Castrucci">Maria R. Castrucci</name><name sortKey="Cesana, Bruno M" sort="Cesana, Bruno M" uniqKey="Cesana B" first="Bruno M." last="Cesana">Bruno M. Cesana</name><name sortKey="Cordioli, Paolo" sort="Cordioli, Paolo" uniqKey="Cordioli P" first="Paolo" last="Cordioli">Paolo Cordioli</name><name sortKey="De Marco, Maria A" sort="De Marco, Maria A" uniqKey="De Marco M" first="Maria A." last="De Marco">Maria A. De Marco</name><name sortKey="Di Carlo, Antonio Scotto" sort="Di Carlo, Antonio Scotto" uniqKey="Di Carlo A" first="Antonio Scotto" last="Di Carlo">Antonio Scotto Di Carlo</name><name sortKey="Di Trani, Livia" sort="Di Trani, Livia" uniqKey="Di Trani L" first="Livia" last="Di Trani">Livia Di Trani</name><name sortKey="Donatelli, Isabella" sort="Donatelli, Isabella" uniqKey="Donatelli I" first="Isabella" last="Donatelli">Isabella Donatelli</name><name sortKey="Moreno, Ana" sort="Moreno, Ana" uniqKey="Moreno A" first="Ana" last="Moreno">Ana Moreno</name><name sortKey="Peri, Vittoria M" sort="Peri, Vittoria M" uniqKey="Peri V" first="Vittoria M." last="Peri">Vittoria M. Peri</name><name sortKey="Porru, Stefano" sort="Porru, Stefano" uniqKey="Porru S" first="Stefano" last="Porru">Stefano Porru</name><name sortKey="Tomao, Paola" sort="Tomao, Paola" uniqKey="Tomao P" first="Paola" last="Tomao">Paola Tomao</name><name sortKey="Vonesch, Nicoletta" sort="Vonesch, Nicoletta" uniqKey="Vonesch N" first="Nicoletta" last="Vonesch">Nicoletta Vonesch</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000892 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000892 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3585202
|texte= Evidence of Cross-Reactive Immunity to 2009 Pandemic Influenza A Virus in Workers Seropositive to Swine H1N1 Influenza Viruses Circulating in Italy
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23469029" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |