Longitudinal and Integrative Biomodeling of Effector and Memory Immune Compartments after Inactivated Influenza Vaccination
Identifieur interne : 000781 ( Main/Exploration ); précédent : 000780; suivant : 000782Longitudinal and Integrative Biomodeling of Effector and Memory Immune Compartments after Inactivated Influenza Vaccination
Auteurs : O. Bonduelle [France] ; N. Yahia [France] ; S. Siberil [France] ; N. Benhabiles [France] ; F. Carrat [France] ; A. Krivine [France] ; F. Rozenberg [France] ; J. Dimitrov ; S. Kaveri ; A. Curjol [France] ; M. Tindel [France] ; M. Louet [France] ; F. Desert [France] ; O. Launay [France] ; P. Loulergue [France] ; G. Badre [France] ; C. Katlama [France] ; F. Bricaire [France] ; A. Samri [France] ; D. Rousset [France] ; S. Van Der Werf [France] ; S. Jauréguiberry [France] ; B. Combadiere [France]Source :
- Journal of Immunology [ 0022-1767 ] ; 2013-07-03.
Abstract
Most vaccines, including those against influenza, were developed by focusing solely on humoral response for protection. However, vaccination activates different adaptive compartments that might play a role in protection. We took advantage of the pandemic 2009 A(H1N1) influenza vaccination to conduct a longitudinal integrative multiparametric analysis of seven immune parameters in vaccinated subjects. A global analysis underlined the predominance of induction of humoral and CD4 T cell responses, whereas pandemic 2009 A(H1N1)-specific CD8 responses did not improve after vaccination. A principal component analysis and hierarchical clustering of individuals showed a differential upregulation of influenza vaccine-specific immunity including hemagglutination inhibition titers, IgA$^+$ and IgG$^+$ Ab-secreting cells, effector CD4 or CD8 T cell frequencies at day 21 among individuals, suggesting a fine-tuning of the immune parameters after vaccination. This is related to individual factors including the magnitude and quality of influenza-specific immune responses before vaccination. We propose a graphical delineation of immune determinants that would be essential for a better understanding of vaccine-induced immunity in vaccination strategies
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DOI: 10.4049/jimmunol.1203483
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Loulergue</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Badre, G" sort="Badre, G" uniqKey="Badre G" first="G." last="Badre">G. Badre</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-444301" status="VALID"> <orgName>AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris]</orgName> <desc> <address> <addrLine>Bâtiment Port-Royal - 53 Avenue de l'Observatoire 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Katlama, C" sort="Katlama, C" uniqKey="Katlama C" first="C." last="Katlama">C. Katlama</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-17930" status="VALID"> <orgName>Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière]</orgName> <desc> <address> <addrLine>47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Bricaire, F" sort="Bricaire, F" uniqKey="Bricaire F" first="F." last="Bricaire">F. Bricaire</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-17930" status="VALID"> <orgName>Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière]</orgName> <desc> <address> <addrLine>47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Samri, A" sort="Samri, A" uniqKey="Samri A" first="A." last="Samri">A. Samri</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Rousset, D" sort="Rousset, D" uniqKey="Rousset D" first="D." last="Rousset">D. Rousset</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-417138" status="OLD"> <idno type="IdRef">235658278</idno> <idno type="RNSR">200818198A</idno> <orgName>Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses</orgName> <orgName type="acronym">GMV-ARN (UMR_3569 / U-Pasteur_2)</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>Département de Virologie, 25-28 rue du docteur Roux, 75724 Paris cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/en/team/molecular-genetics-of-rna-viruses/</ref> </desc> <listRelation> <relation name="UMR_3569" active="#struct-441569" type="direct"></relation> <relation name="U-Pasteur_2" active="#struct-300301" type="direct"></relation> <relation active="#struct-300027" type="direct"></relation> </listRelation> <tutelles><tutelle name="UMR_3569" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="U-Pasteur_2" active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID"> <idno type="IdRef">027936643</idno> <idno type="ISNI">0000 0001 2353 6535</idno> <orgName>Institut Pasteur [Paris]</orgName> <date type="start">1887-06-04</date> <desc> <address> <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Van Der Werf, S" sort="Van Der Werf, S" uniqKey="Van Der Werf S" first="S." last="Van Der Werf">S. Van Der Werf</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-417138" status="OLD"> <idno type="IdRef">235658278</idno> <idno type="RNSR">200818198A</idno> <orgName>Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses</orgName> <orgName type="acronym">GMV-ARN (UMR_3569 / U-Pasteur_2)</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>Département de Virologie, 25-28 rue du docteur Roux, 75724 Paris cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/en/team/molecular-genetics-of-rna-viruses/</ref> </desc> <listRelation> <relation name="UMR_3569" active="#struct-441569" type="direct"></relation> <relation name="U-Pasteur_2" active="#struct-300301" type="direct"></relation> <relation active="#struct-300027" type="direct"></relation> </listRelation> <tutelles><tutelle name="UMR_3569" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="U-Pasteur_2" active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID"> <idno type="IdRef">027936643</idno> <idno type="ISNI">0000 0001 2353 6535</idno> <orgName>Institut Pasteur [Paris]</orgName> <date type="start">1887-06-04</date> <desc> <address> <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Jaureguiberry, S" sort="Jaureguiberry, S" uniqKey="Jaureguiberry S" first="S." last="Jauréguiberry">S. Jauréguiberry</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-507629" status="INCOMING"> <orgName>Hôpital La Pitie Salpetriere</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Combadiere, B" sort="Combadiere, B" uniqKey="Combadiere B" first="B." last="Combadiere">B. Combadiere</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-246601" status="OLD"> <idno type="RNSR">201420916D</idno> <orgName>Centre d'Immunologie et de Maladies Infectieuses</orgName> <orgName type="acronym">CIMI</orgName> <desc> <address> <addrLine>91 Boulevard de l'hôpital 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.cimi-paris.upmc.fr</ref> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation name="U1135" active="#struct-303623" type="direct"></relation> <relation name="ERL8255" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="OLD"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc> </org></tutelle><tutelle name="U1135" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle name="ERL8255" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></analytic><idno type="DOI">10.4049/jimmunol.1203483</idno><series><title level="j">Journal of Immunology</title><idno type="ISSN">0022-1767</idno><imprint><date type="datePub">2013-07-03</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>Most vaccines, including those against influenza, were developed by focusing solely on humoral response for protection. However, vaccination activates different adaptive compartments that might play a role in protection. We took advantage of the pandemic 2009 A(H1N1) influenza vaccination to conduct a longitudinal integrative multiparametric analysis of seven immune parameters in vaccinated subjects. A global analysis underlined the predominance of induction of humoral and CD4 T cell responses, whereas pandemic 2009 A(H1N1)-specific CD8 responses did not improve after vaccination. A principal component analysis and hierarchical clustering of individuals showed a differential upregulation of influenza vaccine-specific immunity including hemagglutination inhibition titers, IgA$^+$ and IgG$^+$ Ab-secreting cells, effector CD4 or CD8 T cell frequencies at day 21 among individuals, suggesting a fine-tuning of the immune parameters after vaccination. This is related to individual factors including the magnitude and quality of influenza-specific immune responses before vaccination. We propose a graphical delineation of immune determinants that would be essential for a better understanding of vaccine-induced immunity in vaccination strategies</p> </div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Dimitrov, J" sort="Dimitrov, J" uniqKey="Dimitrov J" first="J." last="Dimitrov">J. Dimitrov</name><name sortKey="Kaveri, S" sort="Kaveri, S" uniqKey="Kaveri S" first="S." last="Kaveri">S. Kaveri</name></noCountry><country name="France"><noRegion><name sortKey="Bonduelle, O" sort="Bonduelle, O" uniqKey="Bonduelle O" first="O." last="Bonduelle">O. Bonduelle</name></noRegion><name sortKey="Badre, G" sort="Badre, G" uniqKey="Badre G" first="G." last="Badre">G. Badre</name><name sortKey="Benhabiles, N" sort="Benhabiles, N" uniqKey="Benhabiles N" first="N." last="Benhabiles">N. Benhabiles</name><name sortKey="Bricaire, F" sort="Bricaire, F" uniqKey="Bricaire F" first="F." last="Bricaire">F. Bricaire</name><name sortKey="Carrat, F" sort="Carrat, F" uniqKey="Carrat F" first="F." last="Carrat">F. Carrat</name><name sortKey="Combadiere, B" sort="Combadiere, B" uniqKey="Combadiere B" first="B." last="Combadiere">B. Combadiere</name><name sortKey="Curjol, A" sort="Curjol, A" uniqKey="Curjol A" first="A." last="Curjol">A. Curjol</name><name sortKey="Desert, F" sort="Desert, F" uniqKey="Desert F" first="F." last="Desert">F. Desert</name><name sortKey="Jaureguiberry, S" sort="Jaureguiberry, S" uniqKey="Jaureguiberry S" first="S." last="Jauréguiberry">S. Jauréguiberry</name><name sortKey="Katlama, C" sort="Katlama, C" uniqKey="Katlama C" first="C." last="Katlama">C. Katlama</name><name sortKey="Krivine, A" sort="Krivine, A" uniqKey="Krivine A" first="A." last="Krivine">A. Krivine</name><name sortKey="Launay, O" sort="Launay, O" uniqKey="Launay O" first="O." last="Launay">O. Launay</name><name sortKey="Louet, M" sort="Louet, M" uniqKey="Louet M" first="M." last="Louet">M. Louet</name><name sortKey="Loulergue, P" sort="Loulergue, P" uniqKey="Loulergue P" first="P." last="Loulergue">P. Loulergue</name><name sortKey="Rousset, D" sort="Rousset, D" uniqKey="Rousset D" first="D." last="Rousset">D. Rousset</name><name sortKey="Rozenberg, F" sort="Rozenberg, F" uniqKey="Rozenberg F" first="F." last="Rozenberg">F. Rozenberg</name><name sortKey="Samri, A" sort="Samri, A" uniqKey="Samri A" first="A." last="Samri">A. Samri</name><name sortKey="Siberil, S" sort="Siberil, S" uniqKey="Siberil S" first="S." last="Siberil">S. Siberil</name><name sortKey="Tindel, M" sort="Tindel, M" uniqKey="Tindel M" first="M." last="Tindel">M. Tindel</name><name sortKey="Van Der Werf, S" sort="Van Der Werf, S" uniqKey="Van Der Werf S" first="S." last="Van Der Werf">S. Van Der Werf</name><name sortKey="Yahia, N" sort="Yahia, N" uniqKey="Yahia N" first="N." last="Yahia">N. Yahia</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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