Conformation and Linkage Studies of Specific Oligosaccharides Related to H1N1, H5N1, and Human Flu for Developing the Second Tamiflu
Identifieur interne : 000734 ( Main/Exploration ); précédent : 000733; suivant : 000735Conformation and Linkage Studies of Specific Oligosaccharides Related to H1N1, H5N1, and Human Flu for Developing the Second Tamiflu
Auteurs : Eunsun YooSource :
- Biomolecules & Therapeutics [ 1976-9148 ] ; 2014.
Abstract
The interaction between viral HA (hemagglutinin) and oligosaccharide of the host plays an important role in the infection and transmission of avian and human flu viruses. Until now, this interaction has been classified by sialyl(α2-3) or sialyl(α2-6) linkage specificity of oligosaccharide moieties for avian or human virus, respectively. In the case of H5N1 and newly mutated flu viruses, classification based on the linkage type does not correlate with human infection and human-to-human transmission of these viruses. It is newly suggested that flu infection and transmission to humans require high affinity binding to the extended conformation with long length sialyl(α2-6)galactose containing oligosaccharides. On the other hand, the avian flu virus requires folded conformation with sialyl(α2-3) or short length sialyl(α2-6) containing trisaccharides. This suggests a potential future direction for the development of new species-specific antiviral drugs to prevent and treat pandemic flu.
Url:
DOI: 10.4062/biomolther.2014.005
PubMed: 24753813
PubMed Central: 3975476
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Conformation and Linkage Studies of Specific Oligosaccharides Related to H1N1, H5N1, and Human Flu for Developing the Second Tamiflu</title><author><name sortKey="Yoo, Eunsun" sort="Yoo, Eunsun" uniqKey="Yoo E" first="Eunsun" last="Yoo">Eunsun Yoo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24753813</idno><idno type="pmc">3975476</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975476</idno><idno type="RBID">PMC:3975476</idno><idno type="doi">10.4062/biomolther.2014.005</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000D08</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D08</idno><idno type="wicri:Area/Pmc/Curation">000D08</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D08</idno><idno type="wicri:Area/Pmc/Checkpoint">000521</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000521</idno><idno type="wicri:Area/Ncbi/Merge">000A36</idno><idno type="wicri:Area/Ncbi/Curation">000A36</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A36</idno><idno type="wicri:doubleKey">1976-9148:2014:Yoo E:conformation:and:linkage</idno><idno type="wicri:Area/Main/Merge">000735</idno><idno type="wicri:Area/Main/Curation">000734</idno><idno type="wicri:Area/Main/Exploration">000734</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Conformation and Linkage Studies of Specific Oligosaccharides Related to H1N1, H5N1, and Human Flu for Developing the Second Tamiflu</title><author><name sortKey="Yoo, Eunsun" sort="Yoo, Eunsun" uniqKey="Yoo E" first="Eunsun" last="Yoo">Eunsun Yoo</name></author></analytic><series><title level="j">Biomolecules & Therapeutics</title><idno type="ISSN">1976-9148</idno><idno type="eISSN">2005-4483</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The interaction between viral HA (hemagglutinin) and oligosaccharide of the host plays an important role in the infection and transmission of avian and human flu viruses. Until now, this interaction has been classified by sialyl(α2-3) or sialyl(α2-6) linkage specificity of oligosaccharide moieties for avian or human virus, respectively. In the case of H5N1 and newly mutated flu viruses, classification based on the linkage type does not correlate with human infection and human-to-human transmission of these viruses. It is newly suggested that flu infection and transmission to humans require high affinity binding to the extended conformation with long length sialyl(α2-6)galactose containing oligosaccharides. On the other hand, the avian flu virus requires folded conformation with sialyl(α2-3) or short length sialyl(α2-6) containing trisaccharides. This suggests a potential future direction for the development of new species-specific antiviral drugs to prevent and treat pandemic flu.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Babu, Ys" uniqKey="Babu Y">YS Babu</name></author><author><name sortKey="Chand, P" uniqKey="Chand P">P Chand</name></author><author><name sortKey="Bantia, S" uniqKey="Bantia S">S Bantia</name></author><author><name sortKey="Kotian, P" uniqKey="Kotian P">P Kotian</name></author><author><name sortKey="Dehghani, A" uniqKey="Dehghani A">A Dehghani</name></author><author><name sortKey="El Kattan, Y" uniqKey="El Kattan Y">Y El-Kattan</name></author><author><name sortKey="Lin, Th" uniqKey="Lin T">TH Lin</name></author><author><name sortKey="Hutchison, Tl" uniqKey="Hutchison T">TL Hutchison</name></author><author><name sortKey="Elliott, Aj" uniqKey="Elliott A">AJ Elliott</name></author><author><name sortKey="Parker, Cd" uniqKey="Parker C">CD 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uniqKey="Tisdale M">M Tisdale</name></author><author><name sortKey="Mckimm Breschkin, Jl" uniqKey="Mckimm Breschkin J">JL McKimm-Breschkin</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Yoo, Eunsun" sort="Yoo, Eunsun" uniqKey="Yoo E" first="Eunsun" last="Yoo">Eunsun Yoo</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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