H2N2V1, Main, Exploration, bibRecord, 000732

Cross-immunity and age patterns of influenza A(H5N1) infection

Identifieur interne : 000732 ( Main/Exploration ); précédent : 000731; suivant : 000733

Cross-immunity and age patterns of influenza A(H5N1) infection

Auteurs : A. J. Kucharski ; W. J. Edmunds

Source :

Epidemiology and Infection [ 0950-2688 ] ; 2014.

RBID : PMC:4411649

Abstract

SUMMARY

The age distribution of influenza A(H5N1) cases reported during 2006–2013 varied substantially between countries. As well as underlying demographic profiles, it is possible that cross-immunity contributed to the age distribution of reported cases: seasonal influenza A(H1N1) and avian influenza A(H5N1) share the same neuraminidase subtype, N1. Using a mechanistic model, we measured the extent to which population age distribution and heterosubtypic cross-immunity could explain the observed age patterns in Cambodia, China, Egypt, Indonesia and Vietnam. Our results support experimental evidence that prior infection with H1N1 confers partial cross-immunity to H5N1, and suggest that more than 50% of spillover events did not lead to reported cases of infection as a result. We also identified age groups that have additional risk factors for influenza A(H5N1) not captured by demography or infection history.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411649

DOI: 10.1017/S0950268814001976
PubMed: 25115493
PubMed Central: 4411649

Affiliations:

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Cross-immunity and age patterns of influenza A(H5N1) infection

Cross-immunity and age patterns of influenza A(H5N1) infection

Source :

Abstract

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