Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus
Identifieur interne : 000723 ( Main/Exploration ); précédent : 000722; suivant : 000724Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus
Auteurs : Michael Worobey ; Guan-Zhu Han ; Andrew Rambaut [Royaume-Uni]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2014.
Abstract
The origin of the 1918 pandemic influenza A virus (IAV) and the reasons for its unusual severity are two of the foremost biomedical mysteries of the past century. We infer that the virus arose via reassortment between a preexisting human H1 IAV lineage and an avian virus. Phylogenetic, seroarcheological, and epidemiological evidence indicates those born earlier or later than ∼1880–1900 would have had some protection against the 1918 H1N1 virus, whereas many young adults born from ∼1880–1900 may have lacked such protection because of childhood exposure to an antigenically distinct H3N8 virus. Our findings suggest that better understanding of how initial exposure shapes lifetime immunity may enhance the prediction and control of future IAV pandemics and seasonal epidemics.
Url:
DOI: 10.1073/pnas.1324197111
PubMed: 24778238
PubMed Central: 4050607
Affiliations:
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We infer that the virus arose via reassortment between a preexisting human H1 IAV lineage and an avian virus. Phylogenetic, seroarcheological, and epidemiological evidence indicates those born earlier or later than ∼1880–1900 would have had some protection against the 1918 H1N1 virus, whereas many young adults born from ∼1880–1900 may have lacked such protection because of childhood exposure to an antigenically distinct H3N8 virus. Our findings suggest that better understanding of how initial exposure shapes lifetime immunity may enhance the prediction and control of future IAV pandemics and seasonal epidemics.</p></div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><noCountry><name sortKey="Han, Guan Zhu" sort="Han, Guan Zhu" uniqKey="Han G" first="Guan-Zhu" last="Han">Guan-Zhu Han</name><name sortKey="Worobey, Michael" sort="Worobey, Michael" uniqKey="Worobey M" first="Michael" last="Worobey">Michael Worobey</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Rambaut, Andrew" sort="Rambaut, Andrew" uniqKey="Rambaut A" first="Andrew" last="Rambaut">Andrew Rambaut</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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