Epitope specific T‐cell responses against influenza A in a healthy population
Identifieur interne : 000570 ( Main/Exploration ); précédent : 000569; suivant : 000571Epitope specific T‐cell responses against influenza A in a healthy population
Auteurs : Miloje Savic ; Jennifer L. Dembinski ; Yohan Kim ; Gro Tunheim ; Rebecca J. Cox ; Fredrik Oftung ; Bjoern Peters ; Siri MjaalandSource :
- Immunology [ 0019-2805 ] ; 2015.
Abstract
Pre‐existing human
Url:
DOI: 10.1111/imm.12548
PubMed: 26489873
PubMed Central: 4717245
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000050
- to stream Pmc, to step Curation: 000050
- to stream Pmc, to step Checkpoint: 000403
- to stream Ncbi, to step Merge: 000C35
- to stream Ncbi, to step Curation: 000C35
- to stream Ncbi, to step Checkpoint: 000C35
- to stream Main, to step Merge: 000571
- to stream Main, to step Curation: 000570
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Epitope specific T‐cell responses against influenza A in a healthy population</title>
<author><name sortKey="Savic, Miloje" sort="Savic, Miloje" uniqKey="Savic M" first="Miloje" last="Savic">Miloje Savic</name>
<affiliation><nlm:aff id="imm12548-aff-0001"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="imm12548-aff-0002"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dembinski, Jennifer L" sort="Dembinski, Jennifer L" uniqKey="Dembinski J" first="Jennifer L." last="Dembinski">Jennifer L. Dembinski</name>
<affiliation><nlm:aff id="imm12548-aff-0001"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="imm12548-aff-0002"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kim, Yohan" sort="Kim, Yohan" uniqKey="Kim Y" first="Yohan" last="Kim">Yohan Kim</name>
<affiliation><nlm:aff id="imm12548-aff-0003"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tunheim, Gro" sort="Tunheim, Gro" uniqKey="Tunheim G" first="Gro" last="Tunheim">Gro Tunheim</name>
<affiliation><nlm:aff id="imm12548-aff-0001"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="imm12548-aff-0002"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cox, Rebecca J" sort="Cox, Rebecca J" uniqKey="Cox R" first="Rebecca J." last="Cox">Rebecca J. Cox</name>
<affiliation><nlm:aff id="imm12548-aff-0002"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="imm12548-aff-0004"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Oftung, Fredrik" sort="Oftung, Fredrik" uniqKey="Oftung F" first="Fredrik" last="Oftung">Fredrik Oftung</name>
<affiliation><nlm:aff id="imm12548-aff-0001"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="imm12548-aff-0002"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peters, Bjoern" sort="Peters, Bjoern" uniqKey="Peters B" first="Bjoern" last="Peters">Bjoern Peters</name>
<affiliation><nlm:aff id="imm12548-aff-0003"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mjaaland, Siri" sort="Mjaaland, Siri" uniqKey="Mjaaland S" first="Siri" last="Mjaaland">Siri Mjaaland</name>
<affiliation><nlm:aff id="imm12548-aff-0001"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="imm12548-aff-0002"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26489873</idno>
<idno type="pmc">4717245</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717245</idno>
<idno type="RBID">PMC:4717245</idno>
<idno type="doi">10.1111/imm.12548</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000050</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000050</idno>
<idno type="wicri:Area/Pmc/Curation">000050</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000050</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000403</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000403</idno>
<idno type="wicri:Area/Ncbi/Merge">000C35</idno>
<idno type="wicri:Area/Ncbi/Curation">000C35</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000C35</idno>
<idno type="wicri:doubleKey">0019-2805:2015:Savic M:epitope:specific:t</idno>
<idno type="wicri:Area/Main/Merge">000571</idno>
<idno type="wicri:Area/Main/Curation">000570</idno>
<idno type="wicri:Area/Main/Exploration">000570</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Epitope specific T‐cell responses against influenza A in a healthy population</title>
<author><name sortKey="Savic, Miloje" sort="Savic, Miloje" uniqKey="Savic M" first="Miloje" last="Savic">Miloje Savic</name>
<affiliation><nlm:aff id="imm12548-aff-0001"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="imm12548-aff-0002"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dembinski, Jennifer L" sort="Dembinski, Jennifer L" uniqKey="Dembinski J" first="Jennifer L." last="Dembinski">Jennifer L. Dembinski</name>
<affiliation><nlm:aff id="imm12548-aff-0001"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="imm12548-aff-0002"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kim, Yohan" sort="Kim, Yohan" uniqKey="Kim Y" first="Yohan" last="Kim">Yohan Kim</name>
<affiliation><nlm:aff id="imm12548-aff-0003"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tunheim, Gro" sort="Tunheim, Gro" uniqKey="Tunheim G" first="Gro" last="Tunheim">Gro Tunheim</name>
<affiliation><nlm:aff id="imm12548-aff-0001"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="imm12548-aff-0002"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cox, Rebecca J" sort="Cox, Rebecca J" uniqKey="Cox R" first="Rebecca J." last="Cox">Rebecca J. Cox</name>
<affiliation><nlm:aff id="imm12548-aff-0002"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="imm12548-aff-0004"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Oftung, Fredrik" sort="Oftung, Fredrik" uniqKey="Oftung F" first="Fredrik" last="Oftung">Fredrik Oftung</name>
<affiliation><nlm:aff id="imm12548-aff-0001"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="imm12548-aff-0002"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peters, Bjoern" sort="Peters, Bjoern" uniqKey="Peters B" first="Bjoern" last="Peters">Bjoern Peters</name>
<affiliation><nlm:aff id="imm12548-aff-0003"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mjaaland, Siri" sort="Mjaaland, Siri" uniqKey="Mjaaland S" first="Siri" last="Mjaaland">Siri Mjaaland</name>
<affiliation><nlm:aff id="imm12548-aff-0001"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="imm12548-aff-0002"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Immunology</title>
<idno type="ISSN">0019-2805</idno>
<idno type="eISSN">1365-2567</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p>Pre‐existing human <styled-content style="fixed-case">CD</styled-content>
4<sup>+</sup>
and <styled-content style="fixed-case">CD</styled-content>
8<sup>+</sup>
T‐cell‐mediated immunity may be a useful correlate of protection against severe influenza disease. Identification and evaluation of common epitopes recognized by T cells with broad cross‐reactivity is therefore important to guide universal influenza vaccine development, and to monitor immunological preparedness against pandemics. We have retrieved an optimal combination of <styled-content style="fixed-case">MHC</styled-content>
class I and class <styled-content style="fixed-case">II</styled-content>
restricted epitopes from the Immune Epitope Database (<ext-link ext-link-type="uri" xlink:href="http://www.iedb.org">www.iedb.org</ext-link>
), by defining a fitness score function depending on prevalence, sequence conservancy and <styled-content style="fixed-case">HLA</styled-content>
super‐type coverage. Optimized libraries of <styled-content style="fixed-case">CD</styled-content>
4<sup>+</sup>
and <styled-content style="fixed-case">CD</styled-content>
8<sup>+</sup>
T‐cell epitopes were selected from influenza antigens commonly present in seasonal and pandemic influenza strains from 1934 to 2009. These epitope pools were used to characterize human T‐cell responses in healthy donors using interferon‐<italic>γ</italic>
ELISPOT assays. Upon stimulation, significant <styled-content style="fixed-case">CD</styled-content>
4<sup>+</sup>
and <styled-content style="fixed-case">CD</styled-content>
8<sup>+</sup>
T‐cell responses were induced, primarily recognizing epitopes from the conserved viral core proteins. Furthermore, the <styled-content style="fixed-case">CD</styled-content>
4<sup>+</sup>
and <styled-content style="fixed-case">CD</styled-content>
8<sup>+</sup>
T cells were phenotypically characterized regarding functionality, cytotoxic potential and memory phenotype using flow cytometry. Optimized sets of T‐cell peptide epitopes may be a useful tool to monitor the efficacy of clinical trials, the immune status of a population to predict immunological preparedness against pandemics, as well as being candidates for universal influenza vaccines.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Cox, Rebecca J" sort="Cox, Rebecca J" uniqKey="Cox R" first="Rebecca J." last="Cox">Rebecca J. Cox</name>
<name sortKey="Dembinski, Jennifer L" sort="Dembinski, Jennifer L" uniqKey="Dembinski J" first="Jennifer L." last="Dembinski">Jennifer L. Dembinski</name>
<name sortKey="Kim, Yohan" sort="Kim, Yohan" uniqKey="Kim Y" first="Yohan" last="Kim">Yohan Kim</name>
<name sortKey="Mjaaland, Siri" sort="Mjaaland, Siri" uniqKey="Mjaaland S" first="Siri" last="Mjaaland">Siri Mjaaland</name>
<name sortKey="Oftung, Fredrik" sort="Oftung, Fredrik" uniqKey="Oftung F" first="Fredrik" last="Oftung">Fredrik Oftung</name>
<name sortKey="Peters, Bjoern" sort="Peters, Bjoern" uniqKey="Peters B" first="Bjoern" last="Peters">Bjoern Peters</name>
<name sortKey="Savic, Miloje" sort="Savic, Miloje" uniqKey="Savic M" first="Miloje" last="Savic">Miloje Savic</name>
<name sortKey="Tunheim, Gro" sort="Tunheim, Gro" uniqKey="Tunheim G" first="Gro" last="Tunheim">Gro Tunheim</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000570 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000570 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:4717245 |texte= Epitope specific T‐cell responses against influenza A in a healthy population }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26489873" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a H2N2V1
This area was generated with Dilib version V0.6.33. |