High Antibody-Dependent Cellular Cytotoxicity Antibody Titers to H5N1 and H7N9 Avian Influenza A Viruses in Healthy US Adults and Older Children
Identifieur interne : 000559 ( Main/Exploration ); précédent : 000558; suivant : 000560High Antibody-Dependent Cellular Cytotoxicity Antibody Titers to H5N1 and H7N9 Avian Influenza A Viruses in Healthy US Adults and Older Children
Auteurs : Masanori Terajima ; Mary Dawn T. Co ; John Cruz ; Francis A. EnnisSource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2015.
Abstract
Human influenza is a highly contagious acute respiratory illness that is responsible for significant morbidity and excess mortality worldwide. In addition to neutralizing antibodies, there are antibodies that bind to influenza virus–infected cells and mediate lysis of the infected cells by natural killer (NK) cells (antibody-dependent cellular cytotoxicity [ADCC]) or complement (complement-dependent lysis [CDL]). We analyzed sera obtained from 16 healthy adults (18–63 years of age), 52 children (2–17 years of age), and 10 infants (0.75–1 year of age) in the United States, who were unlikely to have been exposed to the avian H7N9 subtype of influenza A virus, by ADCC and CDL assays. As expected, none of these sera had detectable levels of hemagglutination-inhibiting antibodies against the H7N9 virus, but we unexpectedly found high titers of ADCC antibodies to the H7N9 subtype virus in all sera from adults and children aged ≥8 years.
Url:
DOI: 10.1093/infdis/jiv181
PubMed: 25795791
PubMed Central: 4668882
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000018
- to stream Pmc, to step Curation: 000018
- to stream Pmc, to step Checkpoint: 000395
- to stream Ncbi, to step Merge: 000B48
- to stream Ncbi, to step Curation: 000B48
- to stream Ncbi, to step Checkpoint: 000B48
- to stream Main, to step Merge: 000560
- to stream Main, to step Curation: 000559
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">High Antibody-Dependent Cellular Cytotoxicity Antibody Titers to H5N1 and H7N9 Avian Influenza A Viruses in Healthy US Adults and Older Children</title><author><name sortKey="Terajima, Masanori" sort="Terajima, Masanori" uniqKey="Terajima M" first="Masanori" last="Terajima">Masanori Terajima</name></author><author><name sortKey="Co, Mary Dawn T" sort="Co, Mary Dawn T" uniqKey="Co M" first="Mary Dawn T." last="Co">Mary Dawn T. Co</name></author><author><name sortKey="Cruz, John" sort="Cruz, John" uniqKey="Cruz J" first="John" last="Cruz">John Cruz</name></author><author><name sortKey="Ennis, Francis A" sort="Ennis, Francis A" uniqKey="Ennis F" first="Francis A." last="Ennis">Francis A. Ennis</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25795791</idno><idno type="pmc">4668882</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668882</idno><idno type="RBID">PMC:4668882</idno><idno type="doi">10.1093/infdis/jiv181</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000018</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000018</idno><idno type="wicri:Area/Pmc/Curation">000018</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000018</idno><idno type="wicri:Area/Pmc/Checkpoint">000395</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000395</idno><idno type="wicri:Area/Ncbi/Merge">000B48</idno><idno type="wicri:Area/Ncbi/Curation">000B48</idno><idno type="wicri:Area/Ncbi/Checkpoint">000B48</idno><idno type="wicri:doubleKey">0022-1899:2015:Terajima M:high:antibody:dependent</idno><idno type="wicri:Area/Main/Merge">000560</idno><idno type="wicri:Area/Main/Curation">000559</idno><idno type="wicri:Area/Main/Exploration">000559</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">High Antibody-Dependent Cellular Cytotoxicity Antibody Titers to H5N1 and H7N9 Avian Influenza A Viruses in Healthy US Adults and Older Children</title><author><name sortKey="Terajima, Masanori" sort="Terajima, Masanori" uniqKey="Terajima M" first="Masanori" last="Terajima">Masanori Terajima</name></author><author><name sortKey="Co, Mary Dawn T" sort="Co, Mary Dawn T" uniqKey="Co M" first="Mary Dawn T." last="Co">Mary Dawn T. Co</name></author><author><name sortKey="Cruz, John" sort="Cruz, John" uniqKey="Cruz J" first="John" last="Cruz">John Cruz</name></author><author><name sortKey="Ennis, Francis A" sort="Ennis, Francis A" uniqKey="Ennis F" first="Francis A." last="Ennis">Francis A. Ennis</name></author></analytic><series><title level="j">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Human influenza is a highly contagious acute respiratory illness that is responsible for significant morbidity and excess mortality worldwide. In addition to neutralizing antibodies, there are antibodies that bind to influenza virus–infected cells and mediate lysis of the infected cells by natural killer (NK) cells (antibody-dependent cellular cytotoxicity [ADCC]) or complement (complement-dependent lysis [CDL]). We analyzed sera obtained from 16 healthy adults (18–63 years of age), 52 children (2–17 years of age), and 10 infants (0.75–1 year of age) in the United States, who were unlikely to have been exposed to the avian H7N9 subtype of influenza A virus, by ADCC and CDL assays. As expected, none of these sera had detectable levels of hemagglutination-inhibiting antibodies against the H7N9 virus, but we unexpectedly found high titers of ADCC antibodies to the H7N9 subtype virus in all sera from adults and children aged ≥8 years.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Co, Mary Dawn T" sort="Co, Mary Dawn T" uniqKey="Co M" first="Mary Dawn T." last="Co">Mary Dawn T. Co</name><name sortKey="Cruz, John" sort="Cruz, John" uniqKey="Cruz J" first="John" last="Cruz">John Cruz</name><name sortKey="Ennis, Francis A" sort="Ennis, Francis A" uniqKey="Ennis F" first="Francis A." last="Ennis">Francis A. Ennis</name><name sortKey="Terajima, Masanori" sort="Terajima, Masanori" uniqKey="Terajima M" first="Masanori" last="Terajima">Masanori Terajima</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000559 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000559 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4668882
|texte= High Antibody-Dependent Cellular Cytotoxicity Antibody Titers to H5N1 and H7N9 Avian Influenza A Viruses in Healthy US Adults and Older Children
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25795791" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |