Ethanolic Extract of Melia Fructus Has Anti-influenza A Virus Activity by Affecting Viral Entry and Viral RNA Polymerase
Identifieur interne : 000319 ( Main/Exploration ); précédent : 000318; suivant : 000320Ethanolic Extract of Melia Fructus Has Anti-influenza A Virus Activity by Affecting Viral Entry and Viral RNA Polymerase
Auteurs : Young-Hee Jin ; Jang-Gi Choi ; Won-Kyung Cho ; Jin Yeul MaSource :
- Frontiers in Microbiology [ 1664-302X ] ; 2017.
Abstract
Meliae Fructus (MF) is the dried ripe fruit of
Url:
DOI: 10.3389/fmicb.2017.00476
PubMed: 28400751
PubMed Central: 5368190
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ethanolic Extract of Melia Fructus Has Anti-influenza A Virus Activity by Affecting Viral Entry and Viral RNA Polymerase</title><author><name sortKey="Jin, Young Hee" sort="Jin, Young Hee" uniqKey="Jin Y" first="Young-Hee" last="Jin">Young-Hee Jin</name></author><author><name sortKey="Choi, Jang Gi" sort="Choi, Jang Gi" uniqKey="Choi J" first="Jang-Gi" last="Choi">Jang-Gi Choi</name></author><author><name sortKey="Cho, Won Kyung" sort="Cho, Won Kyung" uniqKey="Cho W" first="Won-Kyung" last="Cho">Won-Kyung Cho</name></author><author><name sortKey="Ma, Jin Yeul" sort="Ma, Jin Yeul" uniqKey="Ma J" first="Jin Yeul" last="Ma">Jin Yeul Ma</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28400751</idno><idno type="pmc">5368190</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368190</idno><idno type="RBID">PMC:5368190</idno><idno type="doi">10.3389/fmicb.2017.00476</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000969</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000969</idno><idno type="wicri:Area/Pmc/Curation">000969</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000969</idno><idno type="wicri:Area/Pmc/Checkpoint">000239</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000239</idno><idno type="wicri:Area/Ncbi/Merge">000D68</idno><idno type="wicri:Area/Ncbi/Curation">000D68</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D68</idno><idno type="wicri:Area/Main/Merge">000319</idno><idno type="wicri:Area/Main/Curation">000319</idno><idno type="wicri:Area/Main/Exploration">000319</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Ethanolic Extract of Melia Fructus Has Anti-influenza A Virus Activity by Affecting Viral Entry and Viral RNA Polymerase</title><author><name sortKey="Jin, Young Hee" sort="Jin, Young Hee" uniqKey="Jin Y" first="Young-Hee" last="Jin">Young-Hee Jin</name></author><author><name sortKey="Choi, Jang Gi" sort="Choi, Jang Gi" uniqKey="Choi J" first="Jang-Gi" last="Choi">Jang-Gi Choi</name></author><author><name sortKey="Cho, Won Kyung" sort="Cho, Won Kyung" uniqKey="Cho W" first="Won-Kyung" last="Cho">Won-Kyung Cho</name></author><author><name sortKey="Ma, Jin Yeul" sort="Ma, Jin Yeul" uniqKey="Ma J" first="Jin Yeul" last="Ma">Jin Yeul Ma</name></author></analytic><series><title level="j">Frontiers in Microbiology</title><idno type="eISSN">1664-302X</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Meliae Fructus (MF) is the dried ripe fruit of <italic>Melia toosendan</italic> Siebold et Zuccarini, Meliaceae family. MF is widely used in traditional medicine to treat inflammation and helminthic infection and has anti-bacterial, anti-oxidant, anti-cancer, anti-inflammatory, and analgesic activities. However, potential anti-influenza properties of MF have yet to be investigated. We determined whether an ethanolic extract of MF (EMF) has anti-viral activity via an EMF pre-, co-, and post-treatment assay, using the Influenza A/PR/8/34 and H3N2 virus on Madin-Darby canine kidney (MDCK) cells. The EMF had anti-influenza virus activity in pre- and co-treated cells in a dose-dependent manner, but not in post-treated cell. EMF inhibited the activity of hemagglutinin (HA) and neuraminidase (NA) of influenza virus. EMF inhibited viral HA, nucleoprotein (NP), matrix protein 2 (M2), non-structural protein 1 (NS1), polymerase acidic protein (PA), polymerase basic protein 1 (PB1), and polymerase basic protein 2 (PB2) mRNA synthesis at 5 h post infection (hpi), however, the levels of PA, PB1, and PB2 mRNA were increased in pre- and co-EMF treated cells compared with control virus-infected and EMF post-treated cells at 18 hpi. The level of M2 protein expression was also decreased upon pre- and co-treatment with EMF. The PA protein was accumulated and localized in not only the nucleus but also the cytoplasm of virus-infected MDCK cells at 18 hpi. Pre-EMF treatment inhibited the expression of pAKT, which is induced by influenza virus infection, at the stage of virus entry. We also found that treatment of EMF up-regulated the antiviral protein Mx1, which may play a partial role in inhibiting influenza virus infection in pre- and co-EMF treated MDCK cells. In summary, these results strongly suggested that an ethanolic extract of Meliae Fructus inhibited influenza A virus infection by affecting viral entry, PA proteins of the RNA polymerase complex, and Mx1 induction and may be a potential and novel anti-influenza agent.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Balish, A L" uniqKey="Balish A">A. L. Balish</name></author><author><name sortKey="Katz, J M" uniqKey="Katz J">J. M. Katz</name></author><author><name sortKey="Klimov, A I" uniqKey="Klimov A">A. I. Klimov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E. De Clercq</name></author><author><name sortKey="Neyts, J" uniqKey="Neyts J">J. Neyts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ehrhardt, C" uniqKey="Ehrhardt C">C. Ehrhardt</name></author><author><name sortKey="Marjuki, H" uniqKey="Marjuki H">H. 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Min</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Cho, Won Kyung" sort="Cho, Won Kyung" uniqKey="Cho W" first="Won-Kyung" last="Cho">Won-Kyung Cho</name><name sortKey="Choi, Jang Gi" sort="Choi, Jang Gi" uniqKey="Choi J" first="Jang-Gi" last="Choi">Jang-Gi Choi</name><name sortKey="Jin, Young Hee" sort="Jin, Young Hee" uniqKey="Jin Y" first="Young-Hee" last="Jin">Young-Hee Jin</name><name sortKey="Ma, Jin Yeul" sort="Ma, Jin Yeul" uniqKey="Ma J" first="Jin Yeul" last="Ma">Jin Yeul Ma</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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