Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic
Identifieur interne : 000168 ( Main/Exploration ); précédent : 000167; suivant : 000169Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic
Auteurs : Alain Gagnon [Canada] ; Enrique Acosta [Canada] ; Stacey Hallman [Canada] ; Robert Bourbeau [Canada] ; Lisa Y. Dillon [Canada] ; Nadine Ouellette [Canada] ; David J. D. Earn [Canada] ; D. Ann Herring [Canada] ; Kris Inwood [Canada] ; Joaquin Madrenas [États-Unis] ; Matthew S. Miller [Canada]Source :
- mBio [ 2150-7511 ] ; 2018.
Descripteurs français
- KwdFr :
- Facteurs de risque, Grippe humaine (immunologie), Grippe humaine (mortalité), Grippe humaine (virologie), Humains, Mexique (épidémiologie), Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H2N2 du virus de la grippe A (immunologie), Susceptibilité à une maladie, États-Unis d'Amérique (épidémiologie).
- MESH :
- immunologie : Grippe humaine, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A.
- mortalité : Grippe humaine.
- virologie : Grippe humaine.
- épidémiologie : Mexique, États-Unis d'Amérique.
- Facteurs de risque, Humains, Susceptibilité à une maladie.
English descriptors
- KwdEn :
- MESH :
- epidemiology : Mexico, United States.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza, Human.
- mortality : Influenza, Human.
- virology : Influenza, Human.
- Disease Susceptibility, Humans, Risk Factors.
Abstract
Recent outbreaks of H5, H7, and H9 influenza A viruses in humans have served as a vivid reminder of the potentially devastating effects that a novel pandemic could exert on the modern world. Those who have survived infections with influenza viruses in the past have been protected from subsequent antigenically similar pandemics through adaptive immunity. For example, during the 2009 H1N1 “swine flu” pandemic, those exposed to H1N1 viruses that circulated between 1918 and the 1940s were at a decreased risk for mortality as a result of their previous immunity. It is also generally thought that past exposures to antigenically dissimilar strains of influenza virus may also be beneficial due to cross-reactive cellular immunity. However, cohorts born during prior heterosubtypic pandemics have previously experienced elevated risk of death relative to surrounding cohorts of the same population. Indeed, individuals born during the 1890 H3Nx pandemic experienced the highest levels of excess mortality during the 1918 “Spanish flu.” Applying Serfling models to monthly mortality and influenza circulation data between October 1997 and July 2014 in the United States and Mexico, we show corresponding peaks in excess mortality during the 2009 H1N1 “swine flu” pandemic and during the resurgent 2013–2014 H1N1 outbreak for those born at the time of the 1957 H2N2 “Asian flu” pandemic. We suggest that the phenomenon observed in 1918 is not unique and points to exposure to pandemic influenza early in life as a risk factor for mortality during subsequent heterosubtypic pandemics.
Url:
DOI: 10.1128/mBio.02091-17
PubMed: 29339427
PubMed Central: 5770550
Affiliations:
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Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Disease Susceptibility</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza A Virus, H2N2 Subtype (immunology)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (mortality)</term>
<term>Influenza, Human (virology)</term>
<term>Mexico (epidemiology)</term>
<term>Risk Factors</term>
<term>United States (epidemiology)</term>
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<term>Grippe humaine (immunologie)</term>
<term>Grippe humaine (mortalité)</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Mexique (épidémiologie)</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
<term>Sous-type H2N2 du virus de la grippe A (immunologie)</term>
<term>Susceptibilité à une maladie</term>
<term>États-Unis d'Amérique (épidémiologie)</term>
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<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
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<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Mexique</term>
<term>États-Unis d'Amérique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Disease Susceptibility</term>
<term>Humans</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Facteurs de risque</term>
<term>Humains</term>
<term>Susceptibilité à une maladie</term>
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>Recent outbreaks of H5, H7, and H9 influenza A viruses in humans have served as a vivid reminder of the potentially devastating effects that a novel pandemic could exert on the modern world. Those who have survived infections with influenza viruses in the past have been protected from subsequent antigenically similar pandemics through adaptive immunity. For example, during the 2009 H1N1 “swine flu” pandemic, those exposed to H1N1 viruses that circulated between 1918 and the 1940s were at a decreased risk for mortality as a result of their previous immunity. It is also generally thought that past exposures to antigenically dissimilar strains of influenza virus may also be beneficial due to cross-reactive cellular immunity. However, cohorts born during prior heterosubtypic pandemics have previously experienced elevated risk of death relative to surrounding cohorts of the same population. Indeed, individuals born during the 1890 H3Nx pandemic experienced the highest levels of excess mortality during the 1918 “Spanish flu.” Applying Serfling models to monthly mortality and influenza circulation data between October 1997 and July 2014 in the United States and Mexico, we show corresponding peaks in excess mortality during the 2009 H1N1 “swine flu” pandemic and during the resurgent 2013–2014 H1N1 outbreak for those born at the time of the 1957 H2N2 “Asian flu” pandemic. We suggest that the phenomenon observed in 1918 is not unique and points to exposure to pandemic influenza early in life as a risk factor for mortality during subsequent heterosubtypic pandemics.</p>
</div>
</front>
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<name sortKey="Ouellette, Nadine" sort="Ouellette, Nadine" uniqKey="Ouellette N" first="Nadine" last="Ouellette">Nadine Ouellette</name>
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<country name="États-Unis"><region name="Californie"><name sortKey="Madrenas, Joaquin" sort="Madrenas, Joaquin" uniqKey="Madrenas J" first="Joaquin" last="Madrenas">Joaquin Madrenas</name>
</region>
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