Highly Pathogenic Avian Influenza H5 Hemagglutinin Fused with the A Subunit of Type IIb Escherichia coli Heat Labile Enterotoxin Elicited Protective Immunity and Neutralization by Intranasal Immunization in Mouse and Chicken Models
Identifieur interne : 000086 ( Main/Exploration ); précédent : 000085; suivant : 000087Highly Pathogenic Avian Influenza H5 Hemagglutinin Fused with the A Subunit of Type IIb Escherichia coli Heat Labile Enterotoxin Elicited Protective Immunity and Neutralization by Intranasal Immunization in Mouse and Chicken Models
Auteurs : Neos Tang ; Shi-Wei Lin ; Ting-Hsuan Chen ; Jia-Tsrong Jan ; Hung-Yi Wu ; Suh-Chin Wu [Taïwan]Source :
- Vaccines [ 2076-393X ] ; 2019.
Abstract
Highly pathogenic avian influenza viruses are classified by the World Organization for Animal Health (OIE) as causes of devastating avian diseases. This study aimed to develop type IIb
Url:
DOI: 10.3390/vaccines7040193
PubMed: 31766677
PubMed Central: 6963717
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Highly Pathogenic Avian Influenza H5 Hemagglutinin Fused with the A Subunit of Type IIb <italic>Escherichia coli</italic> Heat Labile Enterotoxin Elicited Protective Immunity and Neutralization by Intranasal Immunization in Mouse and Chicken Models</title><author><name sortKey="Tang, Neos" sort="Tang, Neos" uniqKey="Tang N" first="Neos" last="Tang">Neos Tang</name><affiliation><nlm:aff id="af1-vaccines-07-00193">Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan;<email>tomtang1107@gmail.com</email> (N.T.);<email>wxes9350409@gmail.com</email> (S.-W.L.);<email>sadam1114@gmail.com</email> (T.-H.C.)</nlm:aff></affiliation></author><author><name sortKey="Lin, Shi Wei" sort="Lin, Shi Wei" uniqKey="Lin S" first="Shi-Wei" last="Lin">Shi-Wei Lin</name><affiliation><nlm:aff id="af1-vaccines-07-00193">Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan;<email>tomtang1107@gmail.com</email> (N.T.);<email>wxes9350409@gmail.com</email> (S.-W.L.);<email>sadam1114@gmail.com</email> (T.-H.C.)</nlm:aff></affiliation></author><author><name sortKey="Chen, Ting Hsuan" sort="Chen, Ting Hsuan" uniqKey="Chen T" first="Ting-Hsuan" last="Chen">Ting-Hsuan Chen</name><affiliation><nlm:aff id="af1-vaccines-07-00193">Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan;<email>tomtang1107@gmail.com</email> (N.T.);<email>wxes9350409@gmail.com</email> (S.-W.L.);<email>sadam1114@gmail.com</email> (T.-H.C.)</nlm:aff></affiliation></author><author><name sortKey="Jan, Jia Tsrong" sort="Jan, Jia Tsrong" uniqKey="Jan J" first="Jia-Tsrong" last="Jan">Jia-Tsrong Jan</name><affiliation><nlm:aff id="af2-vaccines-07-00193">Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan;<email>tsrong33@gate.sinica.edu.tw</email></nlm:aff></affiliation></author><author><name sortKey="Wu, Hung Yi" sort="Wu, Hung Yi" uniqKey="Wu H" first="Hung-Yi" last="Wu">Hung-Yi Wu</name><affiliation><nlm:aff id="af3-vaccines-07-00193">Graduate Institute of Veterinary Pathobiology, National Chung Hsing University, Taichung 402, Taiwan;<email>hwu2@dragon.nchu.edu.tw</email></nlm:aff></affiliation></author><author><name sortKey="Wu, Suh Chin" sort="Wu, Suh Chin" uniqKey="Wu S" first="Suh-Chin" last="Wu">Suh-Chin Wu</name><affiliation><nlm:aff id="af1-vaccines-07-00193">Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan;<email>tomtang1107@gmail.com</email> (N.T.);<email>wxes9350409@gmail.com</email> (S.-W.L.);<email>sadam1114@gmail.com</email> (T.-H.C.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-vaccines-07-00193">Department of Medical Science, National Tsing Hua University, Hsinchu 30013, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Science, National Tsing Hua University, Hsinchu 30013</wicri:regionArea><wicri:noRegion>Hsinchu 30013</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31766677</idno><idno type="pmc">6963717</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963717</idno><idno type="RBID">PMC:6963717</idno><idno type="doi">10.3390/vaccines7040193</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000C34</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C34</idno><idno type="wicri:Area/Pmc/Curation">000C34</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C34</idno><idno type="wicri:Area/Pmc/Checkpoint">000067</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000067</idno><idno type="wicri:Area/Ncbi/Merge">001030</idno><idno type="wicri:Area/Ncbi/Curation">001030</idno><idno type="wicri:Area/Ncbi/Checkpoint">001030</idno><idno type="wicri:Area/Main/Merge">000086</idno><idno type="wicri:Area/Main/Curation">000086</idno><idno type="wicri:Area/Main/Exploration">000086</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Highly Pathogenic Avian Influenza H5 Hemagglutinin Fused with the A Subunit of Type IIb <italic>Escherichia coli</italic> Heat Labile Enterotoxin Elicited Protective Immunity and Neutralization by Intranasal Immunization in Mouse and Chicken Models</title><author><name sortKey="Tang, Neos" sort="Tang, Neos" uniqKey="Tang N" first="Neos" last="Tang">Neos Tang</name><affiliation><nlm:aff id="af1-vaccines-07-00193">Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan;<email>tomtang1107@gmail.com</email> (N.T.);<email>wxes9350409@gmail.com</email> (S.-W.L.);<email>sadam1114@gmail.com</email> (T.-H.C.)</nlm:aff></affiliation></author><author><name sortKey="Lin, Shi Wei" sort="Lin, Shi Wei" uniqKey="Lin S" first="Shi-Wei" last="Lin">Shi-Wei Lin</name><affiliation><nlm:aff id="af1-vaccines-07-00193">Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan;<email>tomtang1107@gmail.com</email> (N.T.);<email>wxes9350409@gmail.com</email> (S.-W.L.);<email>sadam1114@gmail.com</email> (T.-H.C.)</nlm:aff></affiliation></author><author><name sortKey="Chen, Ting Hsuan" sort="Chen, Ting Hsuan" uniqKey="Chen T" first="Ting-Hsuan" last="Chen">Ting-Hsuan Chen</name><affiliation><nlm:aff id="af1-vaccines-07-00193">Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan;<email>tomtang1107@gmail.com</email> (N.T.);<email>wxes9350409@gmail.com</email> (S.-W.L.);<email>sadam1114@gmail.com</email> (T.-H.C.)</nlm:aff></affiliation></author><author><name sortKey="Jan, Jia Tsrong" sort="Jan, Jia Tsrong" uniqKey="Jan J" first="Jia-Tsrong" last="Jan">Jia-Tsrong Jan</name><affiliation><nlm:aff id="af2-vaccines-07-00193">Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan;<email>tsrong33@gate.sinica.edu.tw</email></nlm:aff></affiliation></author><author><name sortKey="Wu, Hung Yi" sort="Wu, Hung Yi" uniqKey="Wu H" first="Hung-Yi" last="Wu">Hung-Yi Wu</name><affiliation><nlm:aff id="af3-vaccines-07-00193">Graduate Institute of Veterinary Pathobiology, National Chung Hsing University, Taichung 402, Taiwan;<email>hwu2@dragon.nchu.edu.tw</email></nlm:aff></affiliation></author><author><name sortKey="Wu, Suh Chin" sort="Wu, Suh Chin" uniqKey="Wu S" first="Suh-Chin" last="Wu">Suh-Chin Wu</name><affiliation><nlm:aff id="af1-vaccines-07-00193">Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan;<email>tomtang1107@gmail.com</email> (N.T.);<email>wxes9350409@gmail.com</email> (S.-W.L.);<email>sadam1114@gmail.com</email> (T.-H.C.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-vaccines-07-00193">Department of Medical Science, National Tsing Hua University, Hsinchu 30013, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Science, National Tsing Hua University, Hsinchu 30013</wicri:regionArea><wicri:noRegion>Hsinchu 30013</wicri:noRegion></affiliation></author></analytic><series><title level="j">Vaccines</title><idno type="eISSN">2076-393X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Highly pathogenic avian influenza viruses are classified by the World Organization for Animal Health (OIE) as causes of devastating avian diseases. This study aimed to develop type IIb <italic>Escherichia</italic><italic>coli</italic> heat-labile enterotoxin (LTIIb) as novel mucosal adjuvants for mucosal vaccine development. The fusion protein of H5 and LTIIb-A subunit was expressed and purified for mouse and chicken intranasal immunizations. Intranasal immunization with the H5-LTIIb-A fusion protein in mice elicited potent neutralizing antibodies in sera and bronchoalveolar lavage fluids, induced stronger Th1 and Th17 cellular responses in spleen and cervical lymph nodes, and improved protection against H5N1 influenza virus challenge. More interestingly, intranasal immunization with the H5-LTIIb-A fusion protein in chickens elicited high titers of IgY, IgA, hemagglutinin inhibition (HAI), and neutralizing antibodies in their antisera. 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Ross</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><noCountry><name sortKey="Chen, Ting Hsuan" sort="Chen, Ting Hsuan" uniqKey="Chen T" first="Ting-Hsuan" last="Chen">Ting-Hsuan Chen</name><name sortKey="Jan, Jia Tsrong" sort="Jan, Jia Tsrong" uniqKey="Jan J" first="Jia-Tsrong" last="Jan">Jia-Tsrong Jan</name><name sortKey="Lin, Shi Wei" sort="Lin, Shi Wei" uniqKey="Lin S" first="Shi-Wei" last="Lin">Shi-Wei Lin</name><name sortKey="Tang, Neos" sort="Tang, Neos" uniqKey="Tang N" first="Neos" last="Tang">Neos Tang</name><name sortKey="Wu, Hung Yi" sort="Wu, Hung Yi" uniqKey="Wu H" first="Hung-Yi" last="Wu">Hung-Yi Wu</name></noCountry><country name="Taïwan"><noRegion><name sortKey="Wu, Suh Chin" sort="Wu, Suh Chin" uniqKey="Wu S" first="Suh-Chin" last="Wu">Suh-Chin Wu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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