Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling
Identifieur interne : 000081 ( Main/Exploration ); précédent : 000080; suivant : 000082Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling
Auteurs : Fanhua Wei [République populaire de Chine] ; Zhimin Jiang [République populaire de Chine] ; Honglei Sun [République populaire de Chine] ; Juan Pu [République populaire de Chine] ; Yipeng Sun [République populaire de Chine] ; Mingyang Wang [République populaire de Chine] ; Qi Tong [République populaire de Chine] ; Yuhai Bi [République populaire de Chine] ; Xiaojing Ma [République populaire de Chine, États-Unis] ; George Fu Gao [République populaire de Chine] ; Jinhua Liu [République populaire de Chine]Source :
- PLoS Pathogens [ 1553-7366 ] ; 2019.
Abstract
Type I interferons (IFNs) play a critical role in host defense against influenza virus infection, and the mechanism of influenza virus to evade type I IFNs responses remains to be fully understood. Here, we found that progranulin (PGRN) was significantly increased both
Url:
DOI: 10.1371/journal.ppat.1008062
PubMed: 31585000
PubMed Central: 6795447
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000B95
- to stream Pmc, to step Curation: 000B95
- to stream Pmc, to step Checkpoint: 000062
- to stream Ncbi, to step Merge: 001014
- to stream Ncbi, to step Curation: 001014
- to stream Ncbi, to step Checkpoint: 001014
- to stream Main, to step Merge: 000081
- to stream Main, to step Curation: 000081
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling</title>
<author><name sortKey="Wei, Fanhua" sort="Wei, Fanhua" uniqKey="Wei F" first="Fanhua" last="Wei">Fanhua Wei</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>College of Agriculture, Ningxia University, Yinchuan, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Agriculture, Ningxia University, Yinchuan</wicri:regionArea>
<wicri:noRegion>Yinchuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jiang, Zhimin" sort="Jiang, Zhimin" uniqKey="Jiang Z" first="Zhimin" last="Jiang">Zhimin Jiang</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sun, Honglei" sort="Sun, Honglei" uniqKey="Sun H" first="Honglei" last="Sun">Honglei Sun</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pu, Juan" sort="Pu, Juan" uniqKey="Pu J" first="Juan" last="Pu">Juan Pu</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sun, Yipeng" sort="Sun, Yipeng" uniqKey="Sun Y" first="Yipeng" last="Sun">Yipeng Sun</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Mingyang" sort="Wang, Mingyang" uniqKey="Wang M" first="Mingyang" last="Wang">Mingyang Wang</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tong, Qi" sort="Tong, Qi" uniqKey="Tong Q" first="Qi" last="Tong">Qi Tong</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bi, Yuhai" sort="Bi, Yuhai" uniqKey="Bi Y" first="Yuhai" last="Bi">Yuhai Bi</name>
<affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ma, Xiaojing" sort="Ma, Xiaojing" uniqKey="Ma X" first="Xiaojing" last="Ma">Xiaojing Ma</name>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff005"><addr-line>Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gao, George Fu" sort="Gao, George Fu" uniqKey="Gao G" first="George Fu" last="Gao">George Fu Gao</name>
<affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Jinhua" sort="Liu, Jinhua" uniqKey="Liu J" first="Jinhua" last="Liu">Jinhua Liu</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31585000</idno>
<idno type="pmc">6795447</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795447</idno>
<idno type="RBID">PMC:6795447</idno>
<idno type="doi">10.1371/journal.ppat.1008062</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000B95</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B95</idno>
<idno type="wicri:Area/Pmc/Curation">000B95</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B95</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000062</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000062</idno>
<idno type="wicri:Area/Ncbi/Merge">001014</idno>
<idno type="wicri:Area/Ncbi/Curation">001014</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001014</idno>
<idno type="wicri:doubleKey">1553-7366:2019:Wei F:induction:of:pgrn</idno>
<idno type="wicri:Area/Main/Merge">000081</idno>
<idno type="wicri:Area/Main/Curation">000081</idno>
<idno type="wicri:Area/Main/Exploration">000081</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling</title>
<author><name sortKey="Wei, Fanhua" sort="Wei, Fanhua" uniqKey="Wei F" first="Fanhua" last="Wei">Fanhua Wei</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>College of Agriculture, Ningxia University, Yinchuan, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Agriculture, Ningxia University, Yinchuan</wicri:regionArea>
<wicri:noRegion>Yinchuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jiang, Zhimin" sort="Jiang, Zhimin" uniqKey="Jiang Z" first="Zhimin" last="Jiang">Zhimin Jiang</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sun, Honglei" sort="Sun, Honglei" uniqKey="Sun H" first="Honglei" last="Sun">Honglei Sun</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pu, Juan" sort="Pu, Juan" uniqKey="Pu J" first="Juan" last="Pu">Juan Pu</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sun, Yipeng" sort="Sun, Yipeng" uniqKey="Sun Y" first="Yipeng" last="Sun">Yipeng Sun</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Mingyang" sort="Wang, Mingyang" uniqKey="Wang M" first="Mingyang" last="Wang">Mingyang Wang</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tong, Qi" sort="Tong, Qi" uniqKey="Tong Q" first="Qi" last="Tong">Qi Tong</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bi, Yuhai" sort="Bi, Yuhai" uniqKey="Bi Y" first="Yuhai" last="Bi">Yuhai Bi</name>
<affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ma, Xiaojing" sort="Ma, Xiaojing" uniqKey="Ma X" first="Xiaojing" last="Ma">Xiaojing Ma</name>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff005"><addr-line>Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gao, George Fu" sort="Gao, George Fu" uniqKey="Gao G" first="George Fu" last="Gao">George Fu Gao</name>
<affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Jinhua" sort="Liu, Jinhua" uniqKey="Liu J" first="Jinhua" last="Liu">Jinhua Liu</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS Pathogens</title>
<idno type="ISSN">1553-7366</idno>
<idno type="eISSN">1553-7374</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Type I interferons (IFNs) play a critical role in host defense against influenza virus infection, and the mechanism of influenza virus to evade type I IFNs responses remains to be fully understood. Here, we found that progranulin (PGRN) was significantly increased both <italic>in vitro</italic>
and <italic>in vivo</italic>
during influenza virus infection. Using a PGRN knockdown assay and PGRN-deficient mice model, we demonstrated that influenza virus-inducing PGRN negatively regulated type I IFNs production by inhibiting the activation of NF-κB and IRF3 signaling. Furthermore, we showed that PGRN directly interacted with NF-κB essential modulator (NEMO) via its Grn CDE domains. We also verified that PGRN recruited A20 to deubiquitinate K63-linked polyubiquitin chains on NEMO at K264. In addition, we found that macrophage played a major source of PGRN during influenza virus infection, and PGRN neutralizing antibodies could protect against influenza virus-induced lethality in mice. Our data identify a PGRN-mediated IFN evasion pathway exploited by influenza virus with implication in antiviral applications. These findings also provide insights into the functions and crosstalk of PGRN in innate immunity.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kilbourne, Ed" uniqKey="Kilbourne E">ED Kilbourne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Petrie, Jg" uniqKey="Petrie J">JG Petrie</name>
</author>
<author><name sortKey="Lauring, As" uniqKey="Lauring A">AS Lauring</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pu, J" uniqKey="Pu J">J Pu</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name>
</author>
<author><name sortKey="Yin, Y" uniqKey="Yin Y">Y Yin</name>
</author>
<author><name sortKey="Zhang, G" uniqKey="Zhang G">G Zhang</name>
</author>
<author><name sortKey="Carter, Ra" uniqKey="Carter R">RA Carter</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
<author><name sortKey="Yuan, H" uniqKey="Yuan H">H Yuan</name>
</author>
<author><name sortKey="Gao, R" uniqKey="Gao R">R Gao</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name>
</author>
<author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name>
</author>
<author><name sortKey="Xiong, Y" uniqKey="Xiong Y">Y Xiong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hrabal, R" uniqKey="Hrabal R">R Hrabal</name>
</author>
<author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name>
</author>
<author><name sortKey="James, S" uniqKey="James S">S James</name>
</author>
<author><name sortKey="Bennett, Hp" uniqKey="Bennett H">HP Bennett</name>
</author>
<author><name sortKey="Ni, F" uniqKey="Ni F">F Ni</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chitramuthu, Bp" uniqKey="Chitramuthu B">BP Chitramuthu</name>
</author>
<author><name sortKey="Bennett, Hpj" uniqKey="Bennett H">HPJ Bennett</name>
</author>
<author><name sortKey="Bateman, A" uniqKey="Bateman A">A Bateman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kessenbrock, K" uniqKey="Kessenbrock K">K Kessenbrock</name>
</author>
<author><name sortKey="Frohlich, L" uniqKey="Frohlich L">L Frohlich</name>
</author>
<author><name sortKey="Sixt, M" uniqKey="Sixt M">M Sixt</name>
</author>
<author><name sortKey="Lammermann, T" uniqKey="Lammermann T">T Lammermann</name>
</author>
<author><name sortKey="Pfister, H" uniqKey="Pfister H">H Pfister</name>
</author>
<author><name sortKey="Bateman, A" uniqKey="Bateman A">A Bateman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhu, J" uniqKey="Zhu J">J Zhu</name>
</author>
<author><name sortKey="Nathan, C" uniqKey="Nathan C">C Nathan</name>
</author>
<author><name sortKey="Jin, W" uniqKey="Jin W">W Jin</name>
</author>
<author><name sortKey="Sim, D" uniqKey="Sim D">D Sim</name>
</author>
<author><name sortKey="Ashcroft, Gs" uniqKey="Ashcroft G">GS Ashcroft</name>
</author>
<author><name sortKey="Wahl, Sm" uniqKey="Wahl S">SM Wahl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="He, Z" uniqKey="He Z">Z He</name>
</author>
<author><name sortKey="Ong, Ch" uniqKey="Ong C">CH Ong</name>
</author>
<author><name sortKey="Halper, J" uniqKey="Halper J">J Halper</name>
</author>
<author><name sortKey="Bateman, A" uniqKey="Bateman A">A Bateman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tang, W" uniqKey="Tang W">W Tang</name>
</author>
<author><name sortKey="Lu, Y" uniqKey="Lu Y">Y Lu</name>
</author>
<author><name sortKey="Tian, Qy" uniqKey="Tian Q">QY Tian</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Guo, Fj" uniqKey="Guo F">FJ Guo</name>
</author>
<author><name sortKey="Liu, Gy" uniqKey="Liu G">GY Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yin, F" uniqKey="Yin F">F Yin</name>
</author>
<author><name sortKey="Banerjee, R" uniqKey="Banerjee R">R Banerjee</name>
</author>
<author><name sortKey="Thomas, B" uniqKey="Thomas B">B Thomas</name>
</author>
<author><name sortKey="Zhou, P" uniqKey="Zhou P">P Zhou</name>
</author>
<author><name sortKey="Qian, L" uniqKey="Qian L">L Qian</name>
</author>
<author><name sortKey="Jia, T" uniqKey="Jia T">T Jia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cruts, M" uniqKey="Cruts M">M Cruts</name>
</author>
<author><name sortKey="Gijselinck, I" uniqKey="Gijselinck I">I Gijselinck</name>
</author>
<author><name sortKey="Van Der Zee, J" uniqKey="Van Der Zee J">J van der Zee</name>
</author>
<author><name sortKey="Engelborghs, S" uniqKey="Engelborghs S">S Engelborghs</name>
</author>
<author><name sortKey="Wils, H" uniqKey="Wils H">H Wils</name>
</author>
<author><name sortKey="Pirici, D" uniqKey="Pirici D">D Pirici</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baker, M" uniqKey="Baker M">M Baker</name>
</author>
<author><name sortKey="Mackenzie, Ir" uniqKey="Mackenzie I">IR Mackenzie</name>
</author>
<author><name sortKey="Pickering Brown, Sm" uniqKey="Pickering Brown S">SM Pickering-Brown</name>
</author>
<author><name sortKey="Gass, J" uniqKey="Gass J">J Gass</name>
</author>
<author><name sortKey="Rademakers, R" uniqKey="Rademakers R">R Rademakers</name>
</author>
<author><name sortKey="Lindholm, C" uniqKey="Lindholm C">C Lindholm</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jian, J" uniqKey="Jian J">J Jian</name>
</author>
<author><name sortKey="Tian, Qy" uniqKey="Tian Q">QY Tian</name>
</author>
<author><name sortKey="Hettinghouse, A" uniqKey="Hettinghouse A">A Hettinghouse</name>
</author>
<author><name sortKey="Zhao, S" uniqKey="Zhao S">S Zhao</name>
</author>
<author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name>
</author>
<author><name sortKey="Wei, J" uniqKey="Wei J">J Wei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brandes, M" uniqKey="Brandes M">M Brandes</name>
</author>
<author><name sortKey="Klauschen, F" uniqKey="Klauschen F">F Klauschen</name>
</author>
<author><name sortKey="Kuchen, S" uniqKey="Kuchen S">S Kuchen</name>
</author>
<author><name sortKey="Germain, Rn" uniqKey="Germain R">RN Germain</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gong, Y" uniqKey="Gong Y">Y Gong</name>
</author>
<author><name sortKey="Zhan, T" uniqKey="Zhan T">T Zhan</name>
</author>
<author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name>
</author>
<author><name sortKey="Zhang, G" uniqKey="Zhang G">G Zhang</name>
</author>
<author><name sortKey="Tan, B" uniqKey="Tan B">B Tan</name>
</author>
<author><name sortKey="Yang, X" uniqKey="Yang X">X Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Suh, Hs" uniqKey="Suh H">HS Suh</name>
</author>
<author><name sortKey="Lo, Y" uniqKey="Lo Y">Y Lo</name>
</author>
<author><name sortKey="Choi, N" uniqKey="Choi N">N Choi</name>
</author>
<author><name sortKey="Letendre, S" uniqKey="Letendre S">S Letendre</name>
</author>
<author><name sortKey="Lee, Sc" uniqKey="Lee S">SC Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gong, Z" uniqKey="Gong Z">Z Gong</name>
</author>
<author><name sortKey="Lv, H" uniqKey="Lv H">H Lv</name>
</author>
<author><name sortKey="Ding, H" uniqKey="Ding H">H Ding</name>
</author>
<author><name sortKey="Han, J" uniqKey="Han J">J Han</name>
</author>
<author><name sortKey="Sun, J" uniqKey="Sun J">J Sun</name>
</author>
<author><name sortKey="Chai, C" uniqKey="Chai C">C Chai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name>
</author>
<author><name sortKey="Liang, W" uniqKey="Liang W">W Liang</name>
</author>
<author><name sortKey="Yang, S" uniqKey="Yang S">S Yang</name>
</author>
<author><name sortKey="Wu, N" uniqKey="Wu N">N Wu</name>
</author>
<author><name sortKey="Gao, H" uniqKey="Gao H">H Gao</name>
</author>
<author><name sortKey="Sheng, J" uniqKey="Sheng J">J Sheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lupfer, C" uniqKey="Lupfer C">C Lupfer</name>
</author>
<author><name sortKey="Thomas, Pg" uniqKey="Thomas P">PG Thomas</name>
</author>
<author><name sortKey="Anand, Pk" uniqKey="Anand P">PK Anand</name>
</author>
<author><name sortKey="Vogel, P" uniqKey="Vogel P">P Vogel</name>
</author>
<author><name sortKey="Milasta, S" uniqKey="Milasta S">S Milasta</name>
</author>
<author><name sortKey="Martinez, J" uniqKey="Martinez J">J Martinez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Song, Z" uniqKey="Song Z">Z Song</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name>
</author>
<author><name sortKey="Xu, F" uniqKey="Xu F">F Xu</name>
</author>
<author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name>
</author>
<author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xing, J" uniqKey="Xing J">J Xing</name>
</author>
<author><name sortKey="Weng, L" uniqKey="Weng L">L Weng</name>
</author>
<author><name sortKey="Yuan, B" uniqKey="Yuan B">B Yuan</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Jia, L" uniqKey="Jia L">L Jia</name>
</author>
<author><name sortKey="Jin, R" uniqKey="Jin R">R Jin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Park, B" uniqKey="Park B">B Park</name>
</author>
<author><name sortKey="Buti, L" uniqKey="Buti L">L Buti</name>
</author>
<author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name>
</author>
<author><name sortKey="Matsuwaki, T" uniqKey="Matsuwaki T">T Matsuwaki</name>
</author>
<author><name sortKey="Spooner, E" uniqKey="Spooner E">E Spooner</name>
</author>
<author><name sortKey="Brinkmann, Mm" uniqKey="Brinkmann M">MM Brinkmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Suh, Hs" uniqKey="Suh H">HS Suh</name>
</author>
<author><name sortKey="Gelman, Bb" uniqKey="Gelman B">BB Gelman</name>
</author>
<author><name sortKey="Lee, Sc" uniqKey="Lee S">SC Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wei, F" uniqKey="Wei F">F Wei</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Jian, J" uniqKey="Jian J">J Jian</name>
</author>
<author><name sortKey="Mundra, Jj" uniqKey="Mundra J">JJ Mundra</name>
</author>
<author><name sortKey="Tian, Q" uniqKey="Tian Q">Q Tian</name>
</author>
<author><name sortKey="Lin, J" uniqKey="Lin J">J Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nielsen, Sr" uniqKey="Nielsen S">SR Nielsen</name>
</author>
<author><name sortKey="Quaranta, V" uniqKey="Quaranta V">V Quaranta</name>
</author>
<author><name sortKey="Linford, A" uniqKey="Linford A">A Linford</name>
</author>
<author><name sortKey="Emeagi, P" uniqKey="Emeagi P">P Emeagi</name>
</author>
<author><name sortKey="Rainer, C" uniqKey="Rainer C">C Rainer</name>
</author>
<author><name sortKey="Santos, A" uniqKey="Santos A">A Santos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Rooijen, N" uniqKey="Van Rooijen N">N van Rooijen</name>
</author>
<author><name sortKey="Sanders, A" uniqKey="Sanders A">A Sanders</name>
</author>
<author><name sortKey="Van Den Berg, Tk" uniqKey="Van Den Berg T">TK van den Berg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bem, Ra" uniqKey="Bem R">RA Bem</name>
</author>
<author><name sortKey="Farnand, Aw" uniqKey="Farnand A">AW Farnand</name>
</author>
<author><name sortKey="Wong, V" uniqKey="Wong V">V Wong</name>
</author>
<author><name sortKey="Koski, A" uniqKey="Koski A">A Koski</name>
</author>
<author><name sortKey="Rosenfeld, Me" uniqKey="Rosenfeld M">ME Rosenfeld</name>
</author>
<author><name sortKey="Van Rooijen, N" uniqKey="Van Rooijen N">N van Rooijen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tate, Md" uniqKey="Tate M">MD Tate</name>
</author>
<author><name sortKey="Pickett, Dl" uniqKey="Pickett D">DL Pickett</name>
</author>
<author><name sortKey="Van Rooijen, N" uniqKey="Van Rooijen N">N van Rooijen</name>
</author>
<author><name sortKey="Brooks, Ag" uniqKey="Brooks A">AG Brooks</name>
</author>
<author><name sortKey="Reading, Pc" uniqKey="Reading P">PC Reading</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luo, Q" uniqKey="Luo Q">Q Luo</name>
</author>
<author><name sortKey="Yan, X" uniqKey="Yan X">X Yan</name>
</author>
<author><name sortKey="Tu, H" uniqKey="Tu H">H Tu</name>
</author>
<author><name sortKey="Yin, Y" uniqKey="Yin Y">Y Yin</name>
</author>
<author><name sortKey="Cao, J" uniqKey="Cao J">J Cao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Iwasaki, A" uniqKey="Iwasaki A">A Iwasaki</name>
</author>
<author><name sortKey="Pillai, Ps" uniqKey="Pillai P">PS Pillai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhong, B" uniqKey="Zhong B">B Zhong</name>
</author>
<author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name>
</author>
<author><name sortKey="Li, S" uniqKey="Li S">S Li</name>
</author>
<author><name sortKey="Wang, Yy" uniqKey="Wang Y">YY Wang</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Diao, F" uniqKey="Diao F">F Diao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krabbe, G" uniqKey="Krabbe G">G Krabbe</name>
</author>
<author><name sortKey="Minami, Ss" uniqKey="Minami S">SS Minami</name>
</author>
<author><name sortKey="Etchegaray, Ji" uniqKey="Etchegaray J">JI Etchegaray</name>
</author>
<author><name sortKey="Taneja, P" uniqKey="Taneja P">P Taneja</name>
</author>
<author><name sortKey="Djukic, B" uniqKey="Djukic B">B Djukic</name>
</author>
<author><name sortKey="Davalos, D" uniqKey="Davalos D">D Davalos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carrero, Ja" uniqKey="Carrero J">JA Carrero</name>
</author>
<author><name sortKey="Calderon, B" uniqKey="Calderon B">B Calderon</name>
</author>
<author><name sortKey="Unanue, Er" uniqKey="Unanue E">ER Unanue</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Auerbuch, V" uniqKey="Auerbuch V">V Auerbuch</name>
</author>
<author><name sortKey="Brockstedt, Dg" uniqKey="Brockstedt D">DG Brockstedt</name>
</author>
<author><name sortKey="Meyer Morse, N" uniqKey="Meyer Morse N">N Meyer-Morse</name>
</author>
<author><name sortKey="O Iordan, M" uniqKey="O Iordan M">M O’Riordan</name>
</author>
<author><name sortKey="Portnoy, Da" uniqKey="Portnoy D">DA Portnoy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="O Onnell, Rm" uniqKey="O Onnell R">RM O’Connell</name>
</author>
<author><name sortKey="Saha, Sk" uniqKey="Saha S">SK Saha</name>
</author>
<author><name sortKey="Vaidya, Sa" uniqKey="Vaidya S">SA Vaidya</name>
</author>
<author><name sortKey="Bruhn, Kw" uniqKey="Bruhn K">KW Bruhn</name>
</author>
<author><name sortKey="Miranda, Ga" uniqKey="Miranda G">GA Miranda</name>
</author>
<author><name sortKey="Zarnegar, B" uniqKey="Zarnegar B">B Zarnegar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Evers, Bm" uniqKey="Evers B">BM Evers</name>
</author>
<author><name sortKey="Rodriguez Navas, C" uniqKey="Rodriguez Navas C">C Rodriguez-Navas</name>
</author>
<author><name sortKey="Tesla, Rj" uniqKey="Tesla R">RJ Tesla</name>
</author>
<author><name sortKey="Prange Kiel, J" uniqKey="Prange Kiel J">J Prange-Kiel</name>
</author>
<author><name sortKey="Wasser, Cr" uniqKey="Wasser C">CR Wasser</name>
</author>
<author><name sortKey="Yoo, Ks" uniqKey="Yoo K">KS Yoo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author><name sortKey="Li, M" uniqKey="Li M">M Li</name>
</author>
<author><name sortKey="Zheng, H" uniqKey="Zheng H">H Zheng</name>
</author>
<author><name sortKey="Muster, T" uniqKey="Muster T">T Muster</name>
</author>
<author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name>
</author>
<author><name sortKey="Beg, Aa" uniqKey="Beg A">AA Beg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Skaug, B" uniqKey="Skaug B">B Skaug</name>
</author>
<author><name sortKey="Jiang, X" uniqKey="Jiang X">X Jiang</name>
</author>
<author><name sortKey="Chen, Zj" uniqKey="Chen Z">ZJ Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xia, X" uniqKey="Xia X">X Xia</name>
</author>
<author><name sortKey="Cui, J" uniqKey="Cui J">J Cui</name>
</author>
<author><name sortKey="Wang, Hy" uniqKey="Wang H">HY Wang</name>
</author>
<author><name sortKey="Zhu, L" uniqKey="Zhu L">L Zhu</name>
</author>
<author><name sortKey="Matsueda, S" uniqKey="Matsueda S">S Matsueda</name>
</author>
<author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kawai, T" uniqKey="Kawai T">T Kawai</name>
</author>
<author><name sortKey="Takahashi, K" uniqKey="Takahashi K">K Takahashi</name>
</author>
<author><name sortKey="Sato, S" uniqKey="Sato S">S Sato</name>
</author>
<author><name sortKey="Coban, C" uniqKey="Coban C">C Coban</name>
</author>
<author><name sortKey="Kumar, H" uniqKey="Kumar H">H Kumar</name>
</author>
<author><name sortKey="Kato, H" uniqKey="Kato H">H Kato</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meylan, E" uniqKey="Meylan E">E Meylan</name>
</author>
<author><name sortKey="Curran, J" uniqKey="Curran J">J Curran</name>
</author>
<author><name sortKey="Hofmann, K" uniqKey="Hofmann K">K Hofmann</name>
</author>
<author><name sortKey="Moradpour, D" uniqKey="Moradpour D">D Moradpour</name>
</author>
<author><name sortKey="Binder, M" uniqKey="Binder M">M Binder</name>
</author>
<author><name sortKey="Bartenschlager, R" uniqKey="Bartenschlager R">R Bartenschlager</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, Lg" uniqKey="Xu L">LG Xu</name>
</author>
<author><name sortKey="Wang, Yy" uniqKey="Wang Y">YY Wang</name>
</author>
<author><name sortKey="Han, Kj" uniqKey="Han K">KJ Han</name>
</author>
<author><name sortKey="Li, Ly" uniqKey="Li L">LY Li</name>
</author>
<author><name sortKey="Zhai, Z" uniqKey="Zhai Z">Z Zhai</name>
</author>
<author><name sortKey="Shu, Hb" uniqKey="Shu H">HB Shu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fitzgerald, Ka" uniqKey="Fitzgerald K">KA Fitzgerald</name>
</author>
<author><name sortKey="Mcwhirter, Sm" uniqKey="Mcwhirter S">SM McWhirter</name>
</author>
<author><name sortKey="Faia, Kl" uniqKey="Faia K">KL Faia</name>
</author>
<author><name sortKey="Rowe, Dc" uniqKey="Rowe D">DC Rowe</name>
</author>
<author><name sortKey="Latz, E" uniqKey="Latz E">E Latz</name>
</author>
<author><name sortKey="Golenbock, Dt" uniqKey="Golenbock D">DT Golenbock</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sankar, S" uniqKey="Sankar S">S Sankar</name>
</author>
<author><name sortKey="Chan, H" uniqKey="Chan H">H Chan</name>
</author>
<author><name sortKey="Romanow, Wj" uniqKey="Romanow W">WJ Romanow</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Bates, Rj" uniqKey="Bates R">RJ Bates</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Zj" uniqKey="Chen Z">ZJ Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reyes Turcu, Fe" uniqKey="Reyes Turcu F">FE Reyes-Turcu</name>
</author>
<author><name sortKey="Ventii, Kh" uniqKey="Ventii K">KH Ventii</name>
</author>
<author><name sortKey="Wilkinson, Kd" uniqKey="Wilkinson K">KD Wilkinson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hu, H" uniqKey="Hu H">H Hu</name>
</author>
<author><name sortKey="Sun, Sc" uniqKey="Sun S">SC Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, Sc" uniqKey="Sun S">SC Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harhaj, Ew" uniqKey="Harhaj E">EW Harhaj</name>
</author>
<author><name sortKey="Dixit, Vm" uniqKey="Dixit V">VM Dixit</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maelfait, J" uniqKey="Maelfait J">J Maelfait</name>
</author>
<author><name sortKey="Roose, K" uniqKey="Roose K">K Roose</name>
</author>
<author><name sortKey="Bogaert, P" uniqKey="Bogaert P">P Bogaert</name>
</author>
<author><name sortKey="Sze, M" uniqKey="Sze M">M Sze</name>
</author>
<author><name sortKey="Saelens, X" uniqKey="Saelens X">X Saelens</name>
</author>
<author><name sortKey="Pasparakis, M" uniqKey="Pasparakis M">M Pasparakis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Coornaert, B" uniqKey="Coornaert B">B Coornaert</name>
</author>
<author><name sortKey="Baens, M" uniqKey="Baens M">M Baens</name>
</author>
<author><name sortKey="Heyninck, K" uniqKey="Heyninck K">K Heyninck</name>
</author>
<author><name sortKey="Bekaert, T" uniqKey="Bekaert T">T Bekaert</name>
</author>
<author><name sortKey="Haegman, M" uniqKey="Haegman M">M Haegman</name>
</author>
<author><name sortKey="Staal, J" uniqKey="Staal J">J Staal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tavares, Rm" uniqKey="Tavares R">RM Tavares</name>
</author>
<author><name sortKey="Turer, Ee" uniqKey="Turer E">EE Turer</name>
</author>
<author><name sortKey="Liu, Cl" uniqKey="Liu C">CL Liu</name>
</author>
<author><name sortKey="Advincula, R" uniqKey="Advincula R">R Advincula</name>
</author>
<author><name sortKey="Scapini, P" uniqKey="Scapini P">P Scapini</name>
</author>
<author><name sortKey="Rhee, L" uniqKey="Rhee L">L Rhee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chu, Y" uniqKey="Chu Y">Y Chu</name>
</author>
<author><name sortKey="Vahl, Jc" uniqKey="Vahl J">JC Vahl</name>
</author>
<author><name sortKey="Kumar, D" uniqKey="Kumar D">D Kumar</name>
</author>
<author><name sortKey="Heger, K" uniqKey="Heger K">K Heger</name>
</author>
<author><name sortKey="Bertossi, A" uniqKey="Bertossi A">A Bertossi</name>
</author>
<author><name sortKey="Wojtowicz, E" uniqKey="Wojtowicz E">E Wojtowicz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Duwel, M" uniqKey="Duwel M">M Duwel</name>
</author>
<author><name sortKey="Welteke, V" uniqKey="Welteke V">V Welteke</name>
</author>
<author><name sortKey="Oeckinghaus, A" uniqKey="Oeckinghaus A">A Oeckinghaus</name>
</author>
<author><name sortKey="Baens, M" uniqKey="Baens M">M Baens</name>
</author>
<author><name sortKey="Kloo, B" uniqKey="Kloo B">B Kloo</name>
</author>
<author><name sortKey="Ferch, U" uniqKey="Ferch U">U Ferch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martens, Lh" uniqKey="Martens L">LH Martens</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name>
</author>
<author><name sortKey="Barmada, Sj" uniqKey="Barmada S">SJ Barmada</name>
</author>
<author><name sortKey="Zhou, P" uniqKey="Zhou P">P Zhou</name>
</author>
<author><name sortKey="Kamiya, S" uniqKey="Kamiya S">S Kamiya</name>
</author>
<author><name sortKey="Sun, B" uniqKey="Sun B">B Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kawase, R" uniqKey="Kawase R">R Kawase</name>
</author>
<author><name sortKey="Ohama, T" uniqKey="Ohama T">T Ohama</name>
</author>
<author><name sortKey="Matsuyama, A" uniqKey="Matsuyama A">A Matsuyama</name>
</author>
<author><name sortKey="Matsuwaki, T" uniqKey="Matsuwaki T">T Matsuwaki</name>
</author>
<author><name sortKey="Okada, T" uniqKey="Okada T">T Okada</name>
</author>
<author><name sortKey="Yamashita, T" uniqKey="Yamashita T">T Yamashita</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tian, R" uniqKey="Tian R">R Tian</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Yao, X" uniqKey="Yao X">X Yao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, K" uniqKey="Huang K">K Huang</name>
</author>
<author><name sortKey="Chen, A" uniqKey="Chen A">A Chen</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name>
</author>
<author><name sortKey="Song, Z" uniqKey="Song Z">Z Song</name>
</author>
<author><name sortKey="Xu, H" uniqKey="Xu H">H Xu</name>
</author>
<author><name sortKey="Cao, J" uniqKey="Cao J">J Cao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jacques, P" uniqKey="Jacques P">P Jacques</name>
</author>
<author><name sortKey="Elewaut, D" uniqKey="Elewaut D">D Elewaut</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
<region><li>État de New York</li>
</region>
<settlement><li>Pékin</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Wei, Fanhua" sort="Wei, Fanhua" uniqKey="Wei F" first="Fanhua" last="Wei">Fanhua Wei</name>
</noRegion>
<name sortKey="Bi, Yuhai" sort="Bi, Yuhai" uniqKey="Bi Y" first="Yuhai" last="Bi">Yuhai Bi</name>
<name sortKey="Gao, George Fu" sort="Gao, George Fu" uniqKey="Gao G" first="George Fu" last="Gao">George Fu Gao</name>
<name sortKey="Jiang, Zhimin" sort="Jiang, Zhimin" uniqKey="Jiang Z" first="Zhimin" last="Jiang">Zhimin Jiang</name>
<name sortKey="Liu, Jinhua" sort="Liu, Jinhua" uniqKey="Liu J" first="Jinhua" last="Liu">Jinhua Liu</name>
<name sortKey="Ma, Xiaojing" sort="Ma, Xiaojing" uniqKey="Ma X" first="Xiaojing" last="Ma">Xiaojing Ma</name>
<name sortKey="Pu, Juan" sort="Pu, Juan" uniqKey="Pu J" first="Juan" last="Pu">Juan Pu</name>
<name sortKey="Sun, Honglei" sort="Sun, Honglei" uniqKey="Sun H" first="Honglei" last="Sun">Honglei Sun</name>
<name sortKey="Sun, Yipeng" sort="Sun, Yipeng" uniqKey="Sun Y" first="Yipeng" last="Sun">Yipeng Sun</name>
<name sortKey="Tong, Qi" sort="Tong, Qi" uniqKey="Tong Q" first="Qi" last="Tong">Qi Tong</name>
<name sortKey="Wang, Mingyang" sort="Wang, Mingyang" uniqKey="Wang M" first="Mingyang" last="Wang">Mingyang Wang</name>
<name sortKey="Wei, Fanhua" sort="Wei, Fanhua" uniqKey="Wei F" first="Fanhua" last="Wei">Fanhua Wei</name>
</country>
<country name="États-Unis"><region name="État de New York"><name sortKey="Ma, Xiaojing" sort="Ma, Xiaojing" uniqKey="Ma X" first="Xiaojing" last="Ma">Xiaojing Ma</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000081 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000081 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:6795447 |texte= Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31585000" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a H2N2V1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |