Role of neuromedin B and its receptor in the innate immune responses against influenza A virus infection in vitro and in vivo
Identifieur interne : 000021 ( Main/Exploration ); précédent : 000020; suivant : 000022Role of neuromedin B and its receptor in the innate immune responses against influenza A virus infection in vitro and in vivo
Auteurs : Guihong Yang ; Huipeng Huang ; Mengyao Tang ; Zifeng Cai ; Cuiqin Huang ; Baomin Qi ; Ji-Long ChenSource :
- Veterinary Research [ 0928-4249 ] ; 2019-12.
Abstract
AbstractThe peptide neuromedin B (NMB) and its receptor (NMBR) represent a system (NMB/NMBR) of neuromodulation. Here, it was demonstrated that the expression of NMBR in cells or murine lung tissues was clearly upregulated in response to H1N1/PR8 influenza A virus infection. Furthermore, the in vitro and in vivo activities of NMB/NMBR during PR8 infection were investigated. It was observed that A549 cells lacking endogenous NMBR were more susceptible to virus infection than control cells, as evidenced by the increased virus production in the cells. Interestingly, a significant decrease in IFN-α and increased IL-6 expression were observed in these cells. The role of this system in innate immunity against PR8 infection was probed by treating mice with NMB. The NMB-treated mice were less susceptible to virus challenge, as evidenced by increased survival, increased body weight, and decreased viral NP expression compared with the control animals. Additionally, the results showed that exogenous NMB not only enhanced IFN-α expression but also appeared to inhibit the expression of NP and IL-6 in PR8-infected cells and animals. As expected, opposing effects were observed in the NMBR antagonist-treated cells and mice, which further confirmed the effects of NMB. Together, these data suggest that NMB/NMBR may be an important component of the host defence against influenza A virus infection. Thus, these proteins may serve as promising candidates for the development of novel antiviral drugs.
Url:
DOI: 10.1186/s13567-019-0695-2
Affiliations:
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Here, it was demonstrated that the expression of NMBR in cells or murine lung tissues was clearly upregulated in response to H1N1/PR8 influenza A virus infection. Furthermore, the in vitro and in vivo activities of NMB/NMBR during PR8 infection were investigated. It was observed that A549 cells lacking endogenous NMBR were more susceptible to virus infection than control cells, as evidenced by the increased virus production in the cells. Interestingly, a significant decrease in IFN-α and increased IL-6 expression were observed in these cells. The role of this system in innate immunity against PR8 infection was probed by treating mice with NMB. The NMB-treated mice were less susceptible to virus challenge, as evidenced by increased survival, increased body weight, and decreased viral NP expression compared with the control animals. Additionally, the results showed that exogenous NMB not only enhanced IFN-α expression but also appeared to inhibit the expression of NP and IL-6 in PR8-infected cells and animals. As expected, opposing effects were observed in the NMBR antagonist-treated cells and mice, which further confirmed the effects of NMB. Together, these data suggest that NMB/NMBR may be an important component of the host defence against influenza A virus infection. Thus, these proteins may serve as promising candidates for the development of novel antiviral drugs.</p> </div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Cai, Zifeng" sort="Cai, Zifeng" uniqKey="Cai Z" first="Zifeng" last="Cai">Zifeng Cai</name><name sortKey="Chen, Ji Long" sort="Chen, Ji Long" uniqKey="Chen J" first="Ji-Long" last="Chen">Ji-Long Chen</name><name sortKey="Huang, Cuiqin" sort="Huang, Cuiqin" uniqKey="Huang C" first="Cuiqin" last="Huang">Cuiqin Huang</name><name sortKey="Huang, Huipeng" sort="Huang, Huipeng" uniqKey="Huang H" first="Huipeng" last="Huang">Huipeng Huang</name><name sortKey="Qi, Baomin" sort="Qi, Baomin" uniqKey="Qi B" first="Baomin" last="Qi">Baomin Qi</name><name sortKey="Tang, Mengyao" sort="Tang, Mengyao" uniqKey="Tang M" first="Mengyao" last="Tang">Mengyao Tang</name><name sortKey="Yang, Guihong" sort="Yang, Guihong" uniqKey="Yang G" first="Guihong" last="Yang">Guihong Yang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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