[Immunogenicity of attenuated reassortants of influenza A virus /Leningrad/134/47/57 (H2N2) for mice, depending on their genome].
Identifieur interne : 002E12 ( Main/Curation ); précédent : 002E11; suivant : 002E13[Immunogenicity of attenuated reassortants of influenza A virus /Leningrad/134/47/57 (H2N2) for mice, depending on their genome].
Auteurs : A Iu Egorov ; L M Garmashova ; G N Nevedomskaia ; L I Bogomolova ; A M Kha Der ; G I AleksandrovaSource :
- Voprosy virusologii [ 0507-4088 ]
Descripteurs français
- KwdFr :
- Animaux, Basse température, Génome viral, Phénotype, Poumon (virologie), Réplication virale, Souris, Souris de lignée CBA, Sous-type H2N2 du virus de la grippe A, Vaccins antigrippaux (immunologie), Vaccins atténués (immunologie), Virus de la grippe A (génétique), Virus de la grippe A (immunologie), Virus de la grippe A (physiologie).
- MESH :
- génétique : Virus de la grippe A.
- immunologie : Vaccins antigrippaux, Vaccins atténués, Virus de la grippe A.
- physiologie : Virus de la grippe A.
- virologie : Poumon.
- Animaux, Basse température, Génome viral, Phénotype, Réplication virale, Souris, Souris de lignée CBA, Sous-type H2N2 du virus de la grippe A.
English descriptors
- KwdEn :
- Animals, Cold Temperature, Genome, Viral, Influenza A Virus, H2N2 Subtype, Influenza A virus (genetics), Influenza A virus (immunology), Influenza A virus (physiology), Influenza Vaccines (immunology), Lung (virology), Mice, Mice, Inbred CBA, Phenotype, Vaccines, Attenuated (immunology), Virus Replication.
- MESH :
- chemical , immunology : Influenza Vaccines, Vaccines, Attenuated.
- genetics : Influenza A virus.
- immunology : Influenza A virus.
- physiology : Influenza A virus.
- virology : Lung.
- Animals, Cold Temperature, Genome, Viral, Influenza A Virus, H2N2 Subtype, Mice, Mice, Inbred CBA, Phenotype, Virus Replication.
Abstract
Reassortants of cold-adapted strain A/Leningrad/134/47/57 (H2N2) and virulent strain A/PR/8/34 (H1N1), modeling genomic composition of vaccinal strains, were tried in mouse experiments. Reassortants' genomes included the major part (5, 6, or 7) from cold-adapted strain and 1 to 3 genes of virulent strain. All the tested reassortants did not differ by temperature sensitivity or cold adaptation phenotypes, did not cause the death of mice, but differed by the level of reproduction in murine lungs and by immunogenicity. Strains with genomic formulas 6/2 (HA and NA of a virulent strain) and 5/3 (M) (HA, NA, and M of a virulent strain) were characterized by the highest immunogenicity. Reassortants including, besides HA and NA, PA gene 5/3 (PA) or inheriting only HA gene from strain A/pr/8/34 (H1N1) were hyperattenuated and low immunogenic.
PubMed: 7716900
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pubmed:7716900Le document en format XML
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<term>Influenza A virus (genetics)</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza A virus (physiology)</term>
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<term>Virus Replication</term>
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<term>Basse température</term>
<term>Génome viral</term>
<term>Phénotype</term>
<term>Poumon (virologie)</term>
<term>Réplication virale</term>
<term>Souris</term>
<term>Souris de lignée CBA</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Vaccins atténués (immunologie)</term>
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<term>Vaccines, Attenuated</term>
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<term>Vaccins atténués</term>
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<term>Cold Temperature</term>
<term>Genome, Viral</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Mice</term>
<term>Mice, Inbred CBA</term>
<term>Phenotype</term>
<term>Virus Replication</term>
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<term>Basse température</term>
<term>Génome viral</term>
<term>Phénotype</term>
<term>Réplication virale</term>
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<front><div type="abstract" xml:lang="en">Reassortants of cold-adapted strain A/Leningrad/134/47/57 (H2N2) and virulent strain A/PR/8/34 (H1N1), modeling genomic composition of vaccinal strains, were tried in mouse experiments. Reassortants' genomes included the major part (5, 6, or 7) from cold-adapted strain and 1 to 3 genes of virulent strain. All the tested reassortants did not differ by temperature sensitivity or cold adaptation phenotypes, did not cause the death of mice, but differed by the level of reproduction in murine lungs and by immunogenicity. Strains with genomic formulas 6/2 (HA and NA of a virulent strain) and 5/3 (M) (HA, NA, and M of a virulent strain) were characterized by the highest immunogenicity. Reassortants including, besides HA and NA, PA gene 5/3 (PA) or inheriting only HA gene from strain A/pr/8/34 (H1N1) were hyperattenuated and low immunogenic.</div>
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