Generation of both cross-reactive and virus-specific T-cell populations after immunization with serologically distinct influenza A viruses
Identifieur interne : 002A42 ( Main/Curation ); précédent : 002A41; suivant : 002A43Generation of both cross-reactive and virus-specific T-cell populations after immunization with serologically distinct influenza A viruses
Auteurs :Source :
- The Journal of Experimental Medicine [ 0022-1007 ] ; 1977.
Abstract
Specificity of cytotoxic T-cell function was investigated for a range of different influenza viruses. T cells from mice immunized with A or B strain influenza viruses, or with vaccinia virus, showed reciprocal exclusion of cytotoxicity. Extensive cross-reactivity was, however, found for lymphocyte populations from mice infected with a variety of serologically distinct influenza A viruses, though serum antibodies did not cross-react when tested in a radioimmunoassay using comparable target cells as immunoadsorbents. This apparent lack of T-cell specificity was recognized for immune spleen cells generated after intraperitoneal inoculation of high titers of virus, and for mediastinal lymph node populations from mice with pneumonia due to infection with much less virus. The phenomenon could not be explained on the basis of exposure to the chicken host component, which is common to A and B strain viruses. However, not all of the virus-immune T-cell clones are cross-reactive. Competitive-inhibition experiments indicate that a considerable proportion of the lymphocyte response is restricted to the immunizing virus. Even so, the less specific component is significant. Also, exposure to one type A virus was found to prime for an enhanced cell-mediated immunity response after challenge with a second, serologically different A strain virus.
Url:
PubMed: 233901
PubMed Central: 2180700
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000A03
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000A03
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000E12
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000872
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000872
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000872
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :002C01
Links to Exploration step
PMC:2180700Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Generation of both cross-reactive and virus-specific T-cell populations after immunization with serologically distinct influenza A viruses</title></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">233901</idno><idno type="pmc">2180700</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180700</idno><idno type="RBID">PMC:2180700</idno><date when="1977">1977</date><idno type="wicri:Area/Pmc/Corpus">000A03</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A03</idno><idno type="wicri:Area/Pmc/Curation">000A03</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A03</idno><idno type="wicri:Area/Pmc/Checkpoint">000E12</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000E12</idno><idno type="wicri:Area/Ncbi/Merge">000872</idno><idno type="wicri:Area/Ncbi/Curation">000872</idno><idno type="wicri:Area/Ncbi/Checkpoint">000872</idno><idno type="wicri:Area/Main/Merge">002C01</idno><idno type="wicri:Area/Main/Curation">002A42</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Generation of both cross-reactive and virus-specific T-cell populations after immunization with serologically distinct influenza A viruses</title></analytic><series><title level="j">The Journal of Experimental Medicine</title><idno type="ISSN">0022-1007</idno><idno type="eISSN">1540-9538</idno><imprint><date when="1977">1977</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Specificity of cytotoxic T-cell function was investigated for a range of different influenza viruses. T cells from mice immunized with A or B strain influenza viruses, or with vaccinia virus, showed reciprocal exclusion of cytotoxicity. Extensive cross-reactivity was, however, found for lymphocyte populations from mice infected with a variety of serologically distinct influenza A viruses, though serum antibodies did not cross-react when tested in a radioimmunoassay using comparable target cells as immunoadsorbents. This apparent lack of T-cell specificity was recognized for immune spleen cells generated after intraperitoneal inoculation of high titers of virus, and for mediastinal lymph node populations from mice with pneumonia due to infection with much less virus. The phenomenon could not be explained on the basis of exposure to the chicken host component, which is common to A and B strain viruses. However, not all of the virus-immune T-cell clones are cross-reactive. Competitive-inhibition experiments indicate that a considerable proportion of the lymphocyte response is restricted to the immunizing virus. Even so, the less specific component is significant. Also, exposure to one type A virus was found to prime for an enhanced cell-mediated immunity response after challenge with a second, serologically different A strain virus.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002A42 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 002A42 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Curation
|type= RBID
|clé= PMC:2180700
|texte= Generation of both cross-reactive and virus-specific T-cell populations after immunization with serologically distinct influenza A viruses
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:233901" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |