Characterization of the 1918 influenza virus hemagglutinin and neuraminidase genes
Identifieur interne : 001849 ( Main/Curation ); précédent : 001848; suivant : 001850Characterization of the 1918 influenza virus hemagglutinin and neuraminidase genes
Auteurs : Jeffery K. Taubenberger [États-Unis] ; Ann H. Reid [États-Unis] ; Thomas A. Janczewski [États-Unis] ; Thomas G. Fanning [États-Unis]Source :
- International congress series [ 0531-5131 ] ; 2001.
English descriptors
- Teeft :
- Amino, Amino acids, Antigenic, Antigenic sites, Avian, Avian consensus, Avian strains, Avian surface proteins, Avian viruses, Forces institute, Gene segments, Gene sequences, Genetic basis, Genetic features, Genetic structure, Glycosylation, Glycosylation sites, Host adaptation, Human influenza strains, Influenza, Influenza genes, Influenza pandemic, Influenza strains, Influenza virus, Influenza virus hemagglutinin, Influenza viruses, International congress series, Mammalian viruses, Mortality rates, Mutation, Pandemic, Phylogenetic analyses, Receptor, Sequence analysis, Taubenberger, Virulence, Virus.
Abstract
Abstract: In the fall and winter of 1918–1919, an influenza pandemic of unprecedented virulence swept the globe leaving 40 million or more dead in its wake. The virus responsible for this catastrophe was not isolated at the time, however, it has recently become possible to study the genetic features of the 1918 ‘Spanish’ influenza virus using frozen and fixed autopsy tissue. Gene sequences of the 1918 virus can be used to frame hypotheses about the origin of the 1918 virus, and to look for clues to its virulence. The study of the 1918 virus is not just one of historical curiosity. An understanding of the genetic make-up of the most virulent influenza strain in history may facilitate prediction and prevention of future pandemics.
Url:
DOI: 10.1016/S0531-5131(01)00629-X
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<front><div type="abstract" xml:lang="en">Abstract: In the fall and winter of 1918–1919, an influenza pandemic of unprecedented virulence swept the globe leaving 40 million or more dead in its wake. The virus responsible for this catastrophe was not isolated at the time, however, it has recently become possible to study the genetic features of the 1918 ‘Spanish’ influenza virus using frozen and fixed autopsy tissue. Gene sequences of the 1918 virus can be used to frame hypotheses about the origin of the 1918 virus, and to look for clues to its virulence. The study of the 1918 virus is not just one of historical curiosity. An understanding of the genetic make-up of the most virulent influenza strain in history may facilitate prediction and prevention of future pandemics.</div>
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