Shotgun glycomics of pig lung identifies natural endogenous receptors for influenza viruses
Identifieur interne : 000667 ( Main/Curation ); précédent : 000666; suivant : 000668Shotgun glycomics of pig lung identifies natural endogenous receptors for influenza viruses
Auteurs : Lauren Byrd-Leotis ; Renpeng Liu ; Konrad C. Bradley ; Yi Lasanajak ; Sandra F. Cummings ; Xuezheng Song ; Jamie Heimburg-Molinaro ; Summer E. Galloway ; Marie R. Culhane ; David F. Smith ; David A. Steinhauer ; Richard D. CummingsSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2014.
Abstract
Studies using novel “shotgun glycan microarray” technology identify, for the first time to our knowledge, the endogenous receptors for influenza viruses from a natural host, the pig. Libraries of total N-glycans from pig lung were probed for binding properties using a panel of influenza viruses isolated from humans, birds, and swine. Natural glycan receptors were identified for all viruses examined, and although some displayed the rather broad α2,3 or α2,6 sialic acid linkage specificity conventionally associated with avian or human viruses, other strains were highly specific, revealing a complexity that has not been demonstrated previously. Because pigs are often implicated as intermediate hosts for pandemic viruses, these results and the approaches described will transform our understanding of influenza host range, transmission, and pathogenicity.
Url:
DOI: 10.1073/pnas.1323162111
PubMed: 24843157
PubMed Central: 4050609
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PMC:4050609Le document en format XML
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55108</nlm:aff>
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<front><div type="abstract" xml:lang="en"><title>Significance</title>
<p>Studies using novel “shotgun glycan microarray” technology identify, for the first time to our knowledge, the endogenous receptors for influenza viruses from a natural host, the pig. Libraries of total N-glycans from pig lung were probed for binding properties using a panel of influenza viruses isolated from humans, birds, and swine. Natural glycan receptors were identified for all viruses examined, and although some displayed the rather broad α2,3 or α2,6 sialic acid linkage specificity conventionally associated with avian or human viruses, other strains were highly specific, revealing a complexity that has not been demonstrated previously. Because pigs are often implicated as intermediate hosts for pandemic viruses, these results and the approaches described will transform our understanding of influenza host range, transmission, and pathogenicity.</p>
</div>
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