Defining the antibody cross-reactome against the influenza virus surface glycoproteins
Identifieur interne : 000335 ( Main/Curation ); précédent : 000334; suivant : 000336Defining the antibody cross-reactome against the influenza virus surface glycoproteins
Auteurs : Raffael Nachbagauer [États-Unis] ; Angela Choi [États-Unis] ; Ariana Hirsh [États-Unis] ; Irina Margine [États-Unis] ; Sayaka Iida [Japon] ; Aldo Barrera [Chili] ; Marcela Ferres [Chili] ; Randy A. Albrecht [États-Unis] ; Adolfo García-Sastre [États-Unis] ; Nicole M. Bouvier [États-Unis] ; Kimihito Ito [Japon] ; Rafael A. Medina [États-Unis, Chili] ; Peter Palese [États-Unis] ; Florian Krammer [États-Unis]Source :
- Nature immunology [ 1529-2908 ] ; 2017.
Abstract
Influenza virus infections induce antibodies against the viral surface glycoproteins hemagglutinin and neuraminidase, and these responses can be broadly protective. To test the breadth and magnitude of antibody responses, mice, guinea pigs and ferrets were sequentially infected with divergent H1N1 or H3N2 viruses. Antibody responses were measured by ELISA against an extensive panel of recombinant glycoproteins representing the viral diversity in nature. Guinea pigs developed high titers of broadly cross-reactive antibodies; mice and ferrets exhibited narrower humoral responses. Then, we compared antibody responses after H1N1 or H3N2 infections in humans and found markedly broad responses and cogent evidence for original antigenic sin. This work will inform universal influenza vaccine design and can guide pandemic preparedness efforts against emerging influenza viruses.
Url:
DOI: 10.1038/ni.3684
PubMed: 28192418
PubMed Central: 5360498
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<affiliation wicri:level="1"><nlm:aff id="A4">Departamento de Infectología e Inmunología Pediátrica, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile</nlm:aff>
<country xml:lang="fr">Chili</country>
<wicri:regionArea>Departamento de Infectología e Inmunología Pediátrica, School of Medicine, Pontificia Universidad Católica de Chile, Santiago</wicri:regionArea>
<wicri:noRegion>Santiago</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A7">Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, Chile</nlm:aff>
<country xml:lang="fr">Chili</country>
<wicri:regionArea>Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago</wicri:regionArea>
<wicri:noRegion>Santiago</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Palese, Peter" sort="Palese, Peter" uniqKey="Palese P" first="Peter" last="Palese">Peter Palese</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krammer, Florian" sort="Krammer, Florian" uniqKey="Krammer F" first="Florian" last="Krammer">Florian Krammer</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature immunology</title>
<idno type="ISSN">1529-2908</idno>
<idno type="eISSN">1529-2916</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p id="P2">Influenza virus infections induce antibodies against the viral surface glycoproteins hemagglutinin and neuraminidase, and these responses can be broadly protective. To test the breadth and magnitude of antibody responses, mice, guinea pigs and ferrets were sequentially infected with divergent H1N1 or H3N2 viruses. Antibody responses were measured by ELISA against an extensive panel of recombinant glycoproteins representing the viral diversity in nature. Guinea pigs developed high titers of broadly cross-reactive antibodies; mice and ferrets exhibited narrower humoral responses. Then, we compared antibody responses after H1N1 or H3N2 infections in humans and found markedly broad responses and cogent evidence for original antigenic sin. This work will inform universal influenza vaccine design and can guide pandemic preparedness efforts against emerging influenza viruses.</p>
</div>
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